Strong Q1 Financial Performance
Total revenue of $2.5 billion, up 2% year-over-year; GAAP diluted EPS $2.15, up 31% YoY; non-GAAP diluted EPS $3.57, up 18% YoY; generated $594 million of free cash flow; exited quarter with $4.7 billion cash and marketable securities and $1.5 billion net debt.
Growth Products Momentum
Growth products generated $851 million in Q1, up 12% year-over-year, and for the first quarter produced more revenue than the remaining MS portfolio.
LEQEMBI Adoption and Persistence
LEQEMBI market revenue $168 million in Q1, up 74% YoY; continues to lead by total patient share in the U.S., Japan and China; real-world persistence ~80% at 18 months and ~70% at 2 years; PDUFA for IQLIK initiation scheduled for May 24 to potentially improve convenience and competitive profile.
SKYCLARYS Global Launch Progress
SKYCLARYS global revenue $151 million in Q1, representing 22% growth YoY; now available in 35 countries with continuing ex-U.S. demand growth and sequential patient uptake outside the U.S.
SPINRAZA High-Dose Approvals and Early Uptake
High-dose SPINRAZA approved in the U.S., Japan and Europe with early patient starts already reported; positive anecdotal reports of switches/back-switches and early conversion rates (Germany reference ~20% conversion in early launch).
Pipeline Progress and Readout Calendar
Notable development progress including durable 1-year benefit data for Salanersen in previously gene‑therapy treated children, first patient dosed in pivotal STELLA-1, positive Phase II data for Litifilimab in SLE/CLE, and a multiyear registrational data flow beginning in 2026 with multiple Phase III readouts planned through the decade.
Strategic Acquisition Opportunity (Apellis)
Proposed Apellis acquisition (SYFOVRE, Empaveli) expected to expand immunology/rare disease portfolio, materially increase EPS outlook and be accretive to non-GAAP EPS in 2027; company plans to fund with ~$3.6 billion cash plus $2 billion in borrowings and expects to repay the new debt by end of 2027.
Felzartamab & Nephrology Expansion
Acquired China rights for felzartamab (TJ Bio transaction) to strengthen nephrology franchise; management cites growing conviction in felzartamab and expects Phase III readouts (AMR) and a meaningful commercial opportunity in IgAN/nephrology.
Maintained Cost Discipline While Investing
Approximately $1.1 billion of non-GAAP core operating expenses in Q1 while increasing investments in late‑stage programs and launches; management underscores disciplined cost posture alongside targeted R&D and commercial spending.
Robust Cash Flow and Capital Allocation Flexibility
Generated $594 million FCF in the quarter and emphasized ability to support business investments and M&A while targeting deleveraging post‑transaction (Apellis) via expected cash flow generation.