Strong EPS, cash generation and balance sheet
Q4 non-GAAP diluted EPS $1.99; FY2025 non-GAAP diluted EPS $15.28 (came in above expectations). Free cash flow $2.1B for the year; cash and marketable securities $4.2B; net debt $2.0B; FY2025 total revenue $9.9B, up ~2% versus 2024.
Growth products driving momentum
Growth products generated $3.3B in FY2025 and >$800M in Q4 2025. Management highlighted strong year-over-year expansion for the growth portfolio (company commentary referenced substantial YoY increases for the growth cohort). Several recently launched products (since 2023) — Lekembi, Skyclaris, Xerxuve, and Calcadi — now generate >$1B combined.
Market leadership for anti-amyloid therapy (Lekembi)
Lekembi reported >60% share of the anti-amyloid therapy market; persistency after plaque‑removal reported at ~70%. Priority review secured for the subcutaneous induction (iClick) with a PDUFA date of May 24, 2026 — potential to reduce infusion burden and broaden access.
Notable product commercial wins
Xerxuve more than doubled sales in 2025. Skyclaris Q4 global revenue $133M, up ~30% YoY (U.S. Q4 $89M); Akembi end‑market sales booked by Eisai ~ $134M in Q4, noted as a step increase (+1054% versus Q3 2025 and Q4 2024 comparisons by management). VUMERITY FY2025 revenue $747M, +19% YoY.
Pipeline expansion and regulatory designations
Pipeline broadened materially during 2025: lidifolumab (litifolumab) received FDA Breakthrough Therapy designation for cutaneous lupus; multiple registrational readouts expected (e.g., litifolumab TOPAZ‑2 readout by end of 2026, BIB080 tau phase 2 mid‑year, SPINRAZA high‑dose PDUFA in April 2026). BTK degrader (BIG145) initiated phase 1 in healthy volunteers.
Strategic BD and acquisition activity
Acquisition of Alcion Therapeutics announced to improve delivery options for intrathecal therapies (e.g., potential convenience improvements for SPINRAZA). New collaborations completed in Q4 with Vanqua and Dara Therapeutics to broaden portfolio and R&D options.