Strong Financial Performance
Arrowhead reported a net income of $370.4 million for the quarter ended March 31, 2025, compared to a net loss of $125.3 million in the same period of 2024. Revenue for the quarter was $542.7 million, primarily due to the license and collaboration agreement with Sarepta.
Upcoming Launch of Plozasiran
Arrowhead is preparing for the commercial launch of Plozasiran for Familial Chylomicronemia Syndrome (FCS), with a PDUFA date set for November 18, 2025. The company is building its commercial sales team and engaging with payers in anticipation of launch.
Advanced Pipeline and Partnerships
The company highlighted its advanced pipeline with multiple Phase III programs, including SHASTA-3, SHASTA-4, and MUIR-3 for severe hypertriglyceridemia (SHTG) and partnerships with Sarepta and Takeda. The Sarepta deal brought in $500 million upfront and potential milestones exceeding $11 billion.
Encouraging Clinical Data
Plozasiran showed reductions in triglycerides by about 80% from baseline in Phase III studies. The company is also seeing progress with obesity candidates ARO-INHBE and ARO-ALK7, with expected initial data by the end of 2025.