Sarepta Therapeutics Collaboration
Arrowhead closed a significant collaboration agreement with Sarepta Therapeutics, expecting to receive $500 million upfront and a total potential value exceeding $11 billion, providing substantial capital infusion and reducing R&D expenses.
Plozasiran Commercial Launch
Pending FDA approval, Arrowhead anticipates the commercial launch of plozasiran for FCS by late 2025, with potential to become a $2 billion to $3 billion per year drug in the SHTG market alone.
Obesity Program Advances
Initiation of Phase I/II clinical trials for obesity candidates ARO-INHBE and ARO-ALK7, with promising preclinical results in fat mass reduction and muscle mass preservation.
CNS Pipeline Development
Development of CNS pipeline with potential treatments for Huntington's, Alzheimer's, and Parkinson's diseases, leveraging new TRiM platform capable of delivering sRNA across the blood-brain barrier.
Strong Cash Position
Arrowhead reports a pro forma cash balance of $1.4 billion, providing runway into 2028 and supporting future growth initiatives.