Strong 2025 Revenue and Proprietary Product Growth
Total 2025 revenues nearly $1,500,000,000; proprietary product portfolio net sales ~ $1,200,000,000, up 9% year‑over‑year; proprietary product sales for the year noted as $1,180,000,000.
Key Product Sales Performance
VIVITROL net sales $467,900,000 (≈2% growth YoY); ARISTADA net sales $370,000,000 (≈7% growth YoY); Livaldi net sales $346,700,000 (≈24% growth YoY).
Profitability and Cash Position
2025 GAAP net income $241,700,000; EBITDA $285,600,000; adjusted EBITDA $394,000,000; year‑end cash and investments ~$1,300,000,000.
Acquisition Completed to Expand Commercial Platform
Acquisition of Avadel closed (Feb 2026), adding LUMRIZE and a sleep commercial team; Alkermes used ~$775,000,000 cash and a $1,525,000,000 term loan to fund the deal; expected Loomrise contribution for remainder of 2026 approx. $315,000,000–$335,000,000.
LUMRIZE Commercial Momentum
LUMRIZE 2025 net sales ≈ $279,000,000 with ~3,500 patients on therapy (≈40% increase vs 2024); Alkermes expects full‑year LUMRIZE revenue $350,000,000–$370,000,000 for 2026 and reported ~$33,000,000 in revenue from the first six weeks post‑close.
Ambitious 2026 Financial Guidance
Company expects 2026 total revenues $1,730,000,000–$1,840,000,000 and adjusted EBITDA $370,000,000–$410,000,000; management stated expectation to generate > $1.7B revenue and > $370M adjusted EBITDA for 2026.
Pipeline Progress — Elixorexant Breakthrough and Phase 3
Elixorexant (orexin 2 receptor agonist) granted FDA Breakthrough Therapy designation; plan to initiate global Phase 3 'Brilliance' program in narcolepsy later this quarter (three 12‑week randomized controlled studies; NT1: two ~150‑patient studies; NT2: ~180 patients) with MWT primary endpoint.
Advancement of Additional Orexin Candidates
ALKS 7,290 and ALKS 4,510 progressed through Phase 1 in healthy volunteers with plans to enter patient studies in 2026 (ALKS 7,290 targeting ADHD with Phase 1b and Phase 2 planned; ALKS 4,510 targeting fatigue in MS/Parkinson's with Phase 2a planned).