Solid Top-Line Revenue Growth
Total revenue of $268 million in Q1 2026, representing +11% year-over-year on an adjusted basis.
DAYBUE Strong Momentum and New Formulation Launch
DAYBUE net sales of $101 million in Q1 2026, up +20% year-over-year; successful launch of DAYBUE STIX with >250 prescriptions recorded (220 shipped in Q1), ~30% of STIX patients were treatment‑naive or restarting therapy, >80% caregiver satisfaction among those who tried STIX, and broader U.S. availability announced.
NUPLAZID Durable Franchise and Demand Growth
NUPLAZID net sales of $167 million in Q1 2026, up +6% year-over-year (adjusted); physician referrals grew ~11% year-over-year and demand grew ~8% year-over-year in Q1; completed a ~30% expansion of the customer‑facing sales force and reiterated pathway to approximately $1 billion annual sales by 2028.
Pipeline Catalysts and Development Progress
Major near-term readouts expected: remlifanserin Phase II top‑line results expected Aug–Oct 2026 and trofinetide Japan Phase III top‑line results expected Sep–Nov 2026; company cites 4 molecules targeting large markets with combined peak sales potential of ~$11 billion (≈$4 billion attributed to remlifanserin); initiated first‑in‑human study of ACP‑271 and anticipates 4 Phase II/III readouts by end of 2027.
Financial Position and Guidance Reaffirmed
Cash balance of $851 million at quarter end (up from $820 million at prior quarter end); reaffirmed 2026 net sales guidance of $1.22 billion to $1.28 billion; R&D expense modestly decreased to $76.9 million (from $78.3 million prior year).
Clinical and KOL Validation
Delphi expert consensus positions DAYBUE as the standard of care for Rett syndrome, supporting adoption across centers of excellence and reinforcing commercial uptake.