Record Revenue and EPS Outperformance
Full-year adjusted EPS of $10, $0.54 above initial guidance midpoint; total net revenues (ex-IPR&D) $61.2B, beating initial guidance by >$2B; sales growth 8.6% led to an all-time high, exceeding prior peak by >$3B despite nearly $16B of U.S. HUMIRA erosion since LOE.
Robust Immunology Momentum (SKYRIZI & RINVOQ)
Q4 immunology revenues ~ $8.6B. SKYRIZI Q4 sales $5B (operational growth 31.9%); RINVOQ Q4 sales ~$2.4B (operational growth 28.6%). Combined FY SKYRIZI + RINVOQ ≈ $25.9B, up ~ $8B YoY; SKYRIZI IBD global sales ~$6.4B in 2025 (more than double prior year); SKYRIZI US biologic psoriasis prescription share >45% and frontline in-play capture ~75% in IBD.
Neuroscience Outperformance and Parkinson's Launch
Full-year neuroscience revenues >$10.7B, up ~$1.8B YoY; Q4 neuroscience +17.3% operational. Key brands: Vraylar $1B, Botox Therapeutic $990M, UBRELVY $339M, QULYPTA $288M. Violet (Parkinson's) Q4 sales $183M, +33% sequential; company now expects Violet to reach blockbuster status in 2026.
Pipeline Progress and R&D Investment
Adjusted R&D expense increased by nearly $1B in 2025, fully funding 90 clinical programs. New approvals include RINVOQ (GCA), EMERALIS (nonsquamous NSCLC), and Epkinle (2L follicular lymphoma). >$5B invested in business development adding in‑vivo CAR T, next‑gen psychedelics, trispecific antibodies, long‑acting amylin analog (ABBV‑295), siRNA platform and a PD‑1/VEGF bispecific from Remagen.
2026 Financial Guidance and Margin Expansion
2026 guidance: total net revenues ≈ $67B (growth 9.5%), adjusted EPS $14.37–$14.57. Forecasted adjusted gross margin >84%, adjusted operating margin ~48.5% (meaningful expansion vs 2025). Free cash flow expected ~$18.5B in 2026 to support dividends and BD.
Strategic U.S. Agreement and Capital Commitment
Voluntary three‑year agreement with the U.S. government to expand patient access (low Medicaid prices, direct-to-patient cash pay options) and commit $100B in U.S. R&D and capital investments over the next decade, aligning affordability and innovation objectives.