Competitive PressureDual IL-17A/F inhibitors have demonstrated impressive efficacy in late-stage trials, raising the bar for efficacy compared to IL-17A-only inhibitors.
Efficacy ChallengesThe ianalumab study did not achieve predefined efficacy thresholds, which was a significant near-term catalyst for Zura Bio Limited.
Skepticism In Drug CombinationSkepticism exists that the fusion of an IL-17A-only inhibitor with a BAFF inhibitor would be advantageous in HS, given the intensifying competition and high benchmark set by IL-17A/F dual inhibitors.