Significant Progress in Clinical Trials
X4 Pharmaceuticals has advanced the 4WARD trial, a global pivotal Phase III clinical trial for mavorixafor in chronic neutropenia (CN), with over 90% of trial sites activated and enrollment underway in over 20 countries. The trial is powered at greater than 95% for the ANC response endpoint and expects full enrollment by Q3/Q4 2025.
Patent Allowance for Mavorixafor
The US Patent Office has issued a notice of allowance for the use of mavorixafor in treating severe chronic idiopathic and autoimmune neutropenia, with the patent expected to expire in March 2041.
Partnerships for Global Expansion
X4 has completed two international partnerships: one with Norgine for commercialization in Europe, Australia, and New Zealand, and another with taiba rare for the Middle East and North Africa (MENA) region.
Strong Financial Position
X4 ended Q1 2025 with nearly $90 million in cash, supporting operations into the first half of 2026. The company reported a net income due to $28 million in license revenue from Norgine and a gain of $10.8 million on Class C warrants.