Strategic Partnership with Dynavax (now Sanofi)
Entered a license and collaboration agreement (Nov 2025) with Dynavax, receiving $25,000,000 upfront and a $5,000,000 equity investment; potential additional $50,000,000 upon Dynavax electing to continue development after Phase 2b FDA submission; total potential deal value up to $700,000,000 including up to $195,000,000 in regulatory milestones, $425,000,000 in sales milestones, and tiered royalties in the low- to mid-teens.
Large Year-over-Year Revenue Increase
Reported full year 2025 revenue of $237.3 million versus $28.7 million in 2024, an increase of approximately 727% year-over-year, driven primarily by BARDA government contracts and revenue recognized from the Dynavax license and collaboration agreement.
Published Positive Norovirus Clinical Data
Published full dataset from Phase 1 dose-ranging study in lactating mothers (n=76) in NPJ Vaccines (Jan 2026). Vaccine was safe and well tolerated; serum norovirus-specific IgA rose ~5.6-fold (G11) and ~4.7-fold (G24) in the high-dose group; breast milk IgA rose ~4-fold (G11) and ~6-fold (G24) at day 29 and was maintained through day 180; exploratory evidence suggests passive transfer of IgA to infants (infant stool increases at days 29 and 60).
Second-Generation Constructs Show Strong Immunogenicity Gains
Head-to-head Phase 1 results (reported June 2025) showed second-generation norovirus constructs produced significantly higher antibody responses versus first-generation: a 141% increase for one strain and a 94% increase for the other—supporting platform improvements applied across COVID-19, flu, and HPV programs.
Cash Position and Extended Runway
Ended Q4 2025 with $63.8 million in cash, cash equivalents, and investments and guidance indicating cash runway into 2027; management is pursuing strategic partnerships and non-dilutive funding to extend runway further.
Operational Cost Management
Entered a lease termination agreement to end a lease early (from 03/31/2029 to 05/15/2026), expected to provide significant operating cost savings and better focus of financial resources on lead programs.