Vigil Neuroscience, Inc. (VIGL) AI Stock Analysis

• Market Cap: $383.88M
• Dividend Yield: N/A
• Average Volume (3M): 936.52K
• Price to Earnings (P/E): ―
• Beta (1Y): -0.22
• Revenue Growth: N/A
• EPS Growth: 3.01%
• Country: US
• Employees: 69
• Sector: Healthcare
• Sector Strength: 41
• Industry: Biotechnology
• EPS (TTM): -0.49
• Shares Outstanding: 47,687,000
• 10 Day Avg. Volume: 1,257,583
• 30 Day Avg. Volume: 936,517
• PEG Ratio: 0.29
• Price to Book (P/B): 0.97
• Price to Sales (P/S): 0.00
• P/FCF Ratio: -1.35
• Enterprise Value/Market Cap: 0.02
• Enterprise Value/Revenue: 16.80
• Enterprise Value/Gross Profit: -632.65
• Enterprise Value/Ebitda: -0.08
• 1Y Price Target: $8.00
• Price Target Upside: -0.62% Downside
• Rating Consensus: Hold
• Number of Analyst Covering: 8

• Rating: 35 Underperform
• Price Target: ―

Vigil Neuroscience Inc's stock score is primarily affected by its weak financial performance, characterized by no revenue generation and negative cash flows. The technical analysis shows some short-term positive momentum, but valuation concerns and the overbought condition suggest caution. The lack of earnings call and corporate events data means these factors did not influence the score.

Positive Factors

Acquisition

The Sanofi acquisition for $8 per share is fairly valued with potential upside from the $2 CVR related to the VG-3927 first commercial sale.

Clinical Data

Biomarker analysis revealed a dose-dependent reduction of nearly 50% in CSF sTREM2 levels, confirming robust and sustained target engagement that supports the agonist activity of VG-3927.

Negative Factors

Acquisition Impact

The stock rating for VIGL has been downgraded to Hold from Buy due to a proposed acquisition by SNY.

Clinical Study

The Phase II IGNITE study of iluzanebart showed no beneficial effects on biomarker or clinical efficacy endpoints in ALSP patients.

Vigil Neuroscience, Inc. Business Overview & Revenue Model

Company Description

Vigil Neuroscience Inc (VIGL) is a biotechnology company focused on the development of novel therapeutics for neurodegenerative diseases. Operating within the healthcare and life sciences sectors, the company is dedicated to harnessing the power of microglia, the brain's resident immune cells, to develop innovative treatments aimed at improving the lives of patients suffering from debilitating neurological conditions. Vigil Neuroscience's core products are in various stages of clinical development, targeting diseases with high unmet medical needs.

How the Company Makes Money

Vigil Neuroscience Inc generates revenue primarily through strategic partnerships, collaborations, and potential licensing agreements with other pharmaceutical and biotechnology companies. These partnerships often involve milestone payments, research and development funding, and royalties on future product sales. The company may also secure grants and funding from governmental or non-governmental organizations to support its research initiatives. Additionally, as its products progress through clinical trials and reach commercialization, Vigil Neuroscience may generate revenue from the direct sales of its therapeutic products. However, as of the latest available data, the company is likely still in the pre-revenue stage, focusing heavily on research and development activities.

Vigil Neuroscience, Inc. Financial Statement Overview

Summary

Vigil Neuroscience Inc is facing significant financial challenges. The company has no revenue generation, resulting in persistent losses and negative cash flows. Although there is some improvement in equity and liquidity, the financial stability is weak, with high risks associated with continued operations without revenue growth or cost management improvements.

Income Statement

Vigil Neuroscience Inc has consistently reported zero revenue over the past years, resulting in negative EBIT and net income. The lack of revenue and high losses indicate a challenging financial position. The company's gross and net profit margins are non-existent, highlighting the absence of income generation.

Balance Sheet

The company's balance sheet shows a moderate debt-to-equity ratio, but this is complicated by the negative stockholders' equity in earlier years, which reflects financial instability. The equity ratio is improving, with positive equity in recent years, but overall financial health remains weak. The availability of cash and short-term investments provides some liquidity, but the high accumulated losses are concerning.

Cash Flow

Vigil Neuroscience Inc exhibits negative free cash flow, indicating that the company is not generating enough cash to cover its operations and capital expenditures. The operating cash flow to net income ratio is consistently negative, reflecting inadequate cash generation relative to net losses. Free cash flow has not shown significant improvement, suggesting ongoing cash flow challenges.

Breakdown	TTM	Dec 2024	Dec 2023	Dec 2022	Dec 2021	Dec 2020
Income Statement
Total Revenue	452.00K	0.00	0.00	0.00	0.00	0.00
Gross Profit	-12.00K	-453.00K	-399.00K	-1.01M	-345.00K	0.00
EBITDA	-96.52M	-83.80M	-88.47M	-67.30M	-42.94M	-28.55M
Net Income	-92.17M	-84.26M	-82.64M	-67.73M	-43.25M	-28.55M
Balance Sheet
Total Assets	86.70M	117.69M	140.86M	200.39M	102.44M	25.30M
Cash, Cash Equivalents and Short-Term Investments	66.98M	97.80M	117.94M	186.60M	91.42M	24.15M
Total Debt	12.44M	12.95M	13.85M	176.00K	937.00K	303.00
Total Liabilities	45.44M	46.06M	24.61M	11.31M	171.88M	53.58M
Stockholders Equity	41.26M	71.64M	116.25M	189.08M	-69.44M	-28.28M
Cash Flow
Free Cash Flow	-58.57M	-51.23M	-71.04M	-66.07M	-39.55M	-5.68M
Operating Cash Flow	-58.21M	-51.22M	-70.36M	-65.15M	-39.35M	-5.18M
Investing Cash Flow	24.28M	8.76M	-65.14M	-921.00K	-204.00K	-500.00K
Financing Cash Flow	37.84M	29.49M	888.00K	161.25M	107.75M	29.83M

Vigil Neuroscience, Inc. Technical Analysis

• Technical Analysis Sentiment: Neutral
• Last Price: 8.05
• 50DMA: Positive
• 100DMA: Positive
• 200DMA: Positive
• MACD: Positive
• RSI: Negative
• STOCH: Neutral

Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For VIGL, the sentiment is Neutral. The current price of 8.05 is below the 20-day moving average (MA) of 8.06, above the 50-day MA of 7.97, and above the 200-day MA of 3.80, indicating a neutral trend. The MACD of 0.14 indicates Positive momentum. The RSI at 78.76 is Negative, neither overbought nor oversold. The STOCH value of 38.73 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for VIGL.

Vigil Neuroscience, Inc. Peers Comparison

Name	Overall Rating	Market Cap	P/E Ratio	ROE	Dividend Yield	Revenue Growth	EPS Growth
CRBU	52 Neutral	$186.25M	―	-68.93%	―	-72.45%	-28.60%
XCUR	48 Neutral	$43.28M	―	-150.50%	―	-100.00%	64.16%
Sector *	47 Neutral	C$213.29M	-1.44	-30.58%	3.10%	19.48%	-0.04%
IMAB	45 Neutral	$407.33M	―	-22.38%	―	-100.00%	72.51%
ACHV	37 Underperform	$130.32M	―	-120.11%	―	―	-32.50%
VIGL	35 Underperform	$383.88M	―	-145.68%	―	―	3.01%
UNCY	28 Underperform	$59.12M	―	-3987.11%	―	―	88.03%

Vigil Neuroscience, Inc. Corporate Events

Vigil Neuroscience Announces Positive Phase 1 Trial Results

On January 23, 2025, Vigil Neuroscience announced positive results from its completed Phase 1 clinical trial of VG-3927, a small molecule TREM2 agonist, aimed at treating Alzheimer’s disease. The trial demonstrated a favorable safety and tolerability profile, along with significant pharmacokinetic and pharmacodynamic markers, supporting the drug’s advancement to a Phase 2 trial scheduled for the third quarter of 2025. This development positions VG-3927 as a promising once-daily oral therapy that could offer a more convenient treatment option for Alzheimer’s patients, potentially addressing disease progression beyond targeting amyloid plaques.