Strong Top-Line Growth
Total revenue of $139.1M, up 21% year-over-year; testing revenue $135.1M, up 26% year-over-year.
Volume Expansion
Total volume ~47,600 tests, up 17% YoY; testing volume ~45,200 tests, up 19% YoY; Decipher ~28,000 tests (24% YoY growth); Afirma ~17,200 tests (12% YoY growth).
Improved Pricing and ASP
Blended testing ASP $2,980, up 6% YoY (normalized ex-prior period collections $2,900, up 3% YoY); Decipher ASP growth outpaced Afirma.
Margin Expansion and Profitability
Non-GAAP gross margin 75.7%, up 350 basis points YoY; testing gross margin 70.4%, up 230 basis points YoY; GAAP net income $28.7M and adjusted EBITDA $42.8M (30.8% of revenue), up 73% YoY and above long-term 25% target.
Strong Cash Position and Cash Generation
Generated $35.2M of cash from operations in Q1 and ended the quarter with $439.1M in cash, cash equivalents, and short-term investments.
Operational Improvements for Afirma
Completed full transition to V2 transcriptome workflow, improving no-result rate and contributing ~400 basis points to volume growth in the quarter and enabling broader sample recovery.
Decipher Clinical and Commercial Momentum
Decipher sustained >20% quarterly growth since acquisition; ~30% growth across high-risk categories (radical prostatectomy, biochemical recurrence, metastatic); extensive evidence base with multiple Phase 3 trials (GUIDANCE >2,000 enrolled, PREDICT-RT, ENZIMET readout at ASCO).
Upcoming Product Catalysts
Prosigna LDT commercial launch on track by midyear with OPTIMA Phase 3 ASCO presentation in June; TruMRD whole-genome MRD platform expected to launch initially in MIBC by end of Q2.
Expanding Evidence and Research Assets
Decipher GRID and Afirma GRID research databases expanding; Decipher slide digitization nearing completion (>350,000 images) to support digital pathology/AI collaborations; multiple external validations and conference presentations (AACR, ASCO GU, AUA).
Balanced Investment While Maintaining Profitability
Management increased R&D and S&M investments to support launches and product development while delivering higher adjusted EBITDA and strong operating leverage.