Clinical Validation RiskClinical validation for the program is limited, creating high uncertainty around whether the therapy will deliver meaningful clinical benefit.
Disappointing Long-term DataInitial long-term data fell short of market expectations, leaving uncertainty about the therapy's ability to meet commercial and clinical benchmarks.
Dosing Interpretation RiskGaps in dosing between initial and follow-up treatment complicate interpretation of efficacy data, making definitive conclusions about treatment benefit premature.