Successful CORAL Trial Results
Trevi's CORAL trial for chronic cough in IPF patients met its primary endpoint with statistically significant reductions in 24-hour cough frequency across all dose groups. The Leicester Cough Questionnaire showed marked improvement, with significant increases of 3.7 and 3.4 points for the 54 and 108 mg BID doses, respectively.
Strong Financial Position
Trevi raised approximately $115 million in capital, resulting in a total cash and investments of around $204 million by the end of June 2025, providing a financial runway into 2029.
Phase III Program Planning
Trevi is preparing to initiate Phase III trials for chronic cough in IPF patients in the first half of next year, along with studies for non-IPF interstitial lung diseases and refractory chronic cough.
Positive Stakeholder Feedback
Patient advisory board feedback indicated that the results from the CORAL trial could significantly impact and improve patients' daily lives.