Full Year Revenue Growth
Total revenue for 2025 was $16.6 million, representing 17% year-over-year growth versus $14.2 million in 2024; when excluding related party revenue, total revenue growth was approximately 33% year-over-year.
Quarterly Revenue and Product Mix
Q4 2025 revenue was $4.2 million, up 5% year-over-year from $4.0 million in Q4 2024; Q4 product revenue was $2.8 million and service revenue was $1.2 million. Excluding related party revenue, Q4 revenue grew ~16% YoY.
Strong Installed Base Expansion
Installed base increased to 82 instruments at year-end 2025, a 67% increase from 49 instruments at year-end 2024; approximately 60% of 2025 installs were under the Strategic Instrument Placement Program (SIPP).
Meaningful Consumable Volume Growth
Consumable kit volume increased approximately 69% year-over-year in 2025, demonstrating higher utilization of the Proteograph platform; calculated consumable pull-through per instrument was approximately $113,000 (noting methodological caveats).
Expanding Scientific Validation and Publications
Cumulative peer-reviewed publications nearly doubled from 36 at the end of 2024 to 70 at the end of 2025 (≈94% increase), including high-profile papers in Nature and Nature Genetics and multiple presentations/posters at HUPO 2025.
Commercial Milestone via Customer Launch
Customer PrognomIQ commercially launched ProVue Lung, a proteomics-based LDT for early lung cancer detection in November 2025; Seer holds approximately a 20% fully diluted interest in PrognomIQ.
Product and R&D Progress
Launched Proteograph ONE (3rd-generation assay) and SP200 (2nd-generation automation instrument) in June 2025 enabling throughput >1,000 samples/week (nearly 10x vs 112 samples/week in 2021); roadmap includes PAS v4 with AI/LLM interface in 2026 and a proteoform profiling assay planned for 2027.
Improved Financial Discipline and Cash Position
Operating expenses and stock-based compensation declined (total operating expenses down 19% YoY to $86.5M in 2025); net loss improved to $73.6M in 2025 from $86.6M in 2024. Free cash flow loss improved to ~$45.6M (2025) from $49.4M (2024). Cash, cash equivalents and investments were approximately $241M at year-end 2025.
Share Repurchases and Capital Allocation
Repurchased ~5.3 million Class A shares in 2025 for ≈$10.2M; total repurchases ~11.7M shares (≈$22M) since program inception, reducing shares outstanding by ~13%; Board authorized an additional $25M repurchase program.
Large-Scale Study Selections
Proteograph was selected for multiple population-scale studies in 2025, including a 20,000-sample study with Korea University and a 10,000-sample project with Discovery Life Sciences, demonstrating scalability for large cohorts.