Group sales growth and guidance delivered
Group sales grew 7% in FY2025 (constant exchange rates). Roche met its upgraded guidance (mid-single-digit sales growth) and delivered a strong full-year performance with Core EPS up 11%.
Pharma division outperformance
Pharma sales grew 9% to CHF 47.7 billion (CER) with volumes up 13%. Core operating profit for Pharma rose strongly and the Pharma core operating profit margin improved (group COP up 13%).
Core operating profit and margin expansion
Group core operating profit increased 13% (CER) and core operating margin expanded by +1.9 percentage points year-over-year, reflecting cost containment and targeted investments.
Extensive positive pipeline and regulatory progress
Multiple important readouts and regulatory actions in Q4: EU approval for Gazyva in lupus nephritis; U.S. and EU approval of Lunsumio subcutaneous formulation; U.S. filing for giredestrant; positive Phase III readouts for fenebrutinib (RMS and PPMS), lidERA (giredestrant, adjuvant breast cancer, HR 0.70), PiaSky (aHUS), multiple positive Gazyva Phase IIIs, and other Phase II/III successes. Company reported a record 10 NMEs moving into Phase III.
Notable product growth and market milestones
Key brands delivered strong growth: Phesgo +48% (global conversion >50%, target 60%), Xolair +32% (food allergy; >100,000 patients treated), Polivy strong (U.S. patient share 36% in first-line DLBCL; >CHF 1bn sales in that setting), Ocrevus crossing CHF 7 billion in sales and >17,500 patients on treatment, Evrysdi >21,000 patients on treatment.
Diagnostics innovation and new product launches
Launches and approvals in Diagnostics include AXELIOS Sequencing Solution (next‑generation sequencing), cobas Mass Spec 601 (fully automated clinical mass spec), Elecsys dengue antigen test (CE mark), cobas BV/CV assay (CE mark) and liat Bordetella panel (CLIA waiver). Diagnostics grew 7% excluding China headwinds.
Strategic U.S. government agreement and investment commitment
Roche reached a contractual agreement with the U.S. government that provides tariff/demo-project exemptions in exchange for certain portfolio Medicaid rebates, expanded patient access support and a planned investment of USD 50 billion in the U.S. over five years (R&D and PP&E).
Balance sheet & capital allocation progress
Net debt decreased by CHF 1.1 billion year-over-year; gross debt reduced by CHF 3.1 billion. Roche continued active M&A and intangible investments (FY2025 acquisitions and intangibles ~CHF 5.1 billion) while increasing the dividend in Swiss francs.