Despite strong growth in clinical adoption and partnership with Tempus, revenue and biopharma challenges, as well as a decline in gross margin, weigh on the outlook. The company's robust cash position and potential Medicare coverage provide positive future prospects.

Company Guidance -

Q3 2025

During the Personalis Second Quarter 2025 Earnings Call, the company reported a revenue of $17.2 million, a decrease of 24% compared to the same period last year. This decline was attributed to a volume decline of $5.6 million from Natera and $1.3 million from Moderna. The clinical adoption of NeXT Personal saw a 59% sequential growth in test volume, delivering nearly 3,500 clinical results with a physician base expanding to over 600. The company anticipates securing Medicare coverage for two indications by the end of the year, with the MRD market poised to exceed $20 billion annually. Personalis revised its full-year revenue guidance to a range of $70 million to $80 million, down from $80 million to $90 million, due to biopharma project delays. Despite this, the company expects to achieve biopharma revenue between $11 million and $13 million in the third quarter, with the fourth quarter typically being the best of the year. Personalis ended the second quarter with $173.2 million in cash and projects a cash usage of approximately $75 million for the full year.

Accelerated Clinical Adoption and Growth

The clinical adoption of NeXT Personal is accelerating dramatically with test volume growing 59% sequentially and over 575% from the previous year. The base of ordering physicians has expanded to over 600.

Partnership with Tempus Gaining Momentum

The commercial partnership with Tempus is expanding, now covering four major indications. This partnership is pivotal to the company's strategy and growth.

Path to Securing Medicare Coverage

Personalis is on track to secure Medicare coverage for two indications by the end of the year, which is expected to be a major inflection point for the company.

Strong Cash Position

The company ended the second quarter with $173.2 million in cash and short-term investments, with no significant debt.

MRD Technology Growth

The demand for MRD technology is robust, with plans to grow this segment by 300% to 400% this year.

Personalis (PSNL) Earnings, Revenues Date & History

The upcoming earnings date is based on a company’s previous reporting, and may be updated when the actual date is announced

Daily Earnings Calendar >

PSNL Earnings History

Report Date	Fiscal Quarter	Forecast / EPS	Last Year's EPS	EPS YoY Change	Slides	Play Transcript
Nov 05, 2025	2025 (Q3)	-0.28 / -	-0.64	―	―	―
Aug 05, 2025	2025 (Q2)	-0.24 / -0.23	-0.24	4.17% (<+0.01)	―
May 06, 2025	2025 (Q1)	-0.25 / -0.18	-0.26	30.77% (+0.08)	―
Feb 27, 2025	2024 (Q4)	-0.28 / -0.23	-0.54	57.41% (+0.31)	―
Nov 06, 2024	2024 (Q3)	-0.35 / -0.64	-0.6	-6.67% (-0.04)	―
Aug 07, 2024	2024 (Q2)	-0.37 / -0.24	-0.5	52.00% (+0.26)	―
May 08, 2024	2024 (Q1)	-0.41 / -0.26	-0.61	57.38% (+0.35)	―
Feb 28, 2024	2023 (Q4)	-0.50 / -0.54	-0.67	19.40% (+0.13)	―
Nov 07, 2023	2023 (Q3)	-0.52 / -0.60	-0.58	-3.45% (-0.02)	―
Aug 08, 2023	2023 (Q2)	-0.54 / -0.50	-0.6	16.67% (+0.10)	―

The table shows recent earnings report dates and whether the forecast was beat or missed. See the change in forecast and EPS from the previous year.

Beat

Missed

PSNL Earnings-Related Price Changes

Report Date	Price 1 Day Before	Price 1 Day After	Percentage Change
Aug 05, 2025	$5.64	$4.40	-21.99%
May 06, 2025	$4.00	$4.84	+21.00%
Feb 27, 2025	$4.24	$4.14	-2.36%
Nov 06, 2024	$5.58	$4.32	-22.58%

Earnings announcements can affect a stock’s price. This table shows the stock's price the day before and the day after recent earnings reports, including the percentage change.

FAQ

When does Personalis Inc (PSNL) report earnings?

Personalis Inc (PSNL) is schdueled to report earning on Nov 05, 2025, After Close (Confirmed).

What is Personalis Inc (PSNL) earnings time?

Personalis Inc (PSNL) earnings time is at Nov 05, 2025, After Close (Confirmed).

Where can I see when companies are reporting earnings?

You can see which companies are reporting today on our designated earnings calendar.

What companies are reporting earnings today?

You can see a list of the companies which are reporting today on TipRanks earnings calendar.

What is PSNL EPS forecast?

PSNL EPS forecast for the fiscal quarter 2025 (Q3) is -0.28.

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