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Phio Pharmaceuticals
(NASDAQ:PHIO)
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Rating:49Neutral
Price Target:
$1.00
▼(-3.85% Downside)
Action:Reiterated
Date:07/21/26
The score is primarily constrained by weak financial performance (pre-revenue losses and sustained cash burn), partially offset by a low-debt balance sheet. Technicals are mixed (short-term improvement but longer-term trend still weak), while valuation is limited by negative earnings and no dividend support. A recent board addition with relevant clinical/regulatory expertise is a modest positive.
Positive Factors
Low leverage / net-cash posture
An essentially debt-free, net-cash balance sheet materially reduces solvency and interest-rate risk for a pre-revenue biotech. This structural strength lengthens operational flexibility and runway versus leveraged peers, allowing management to prioritize clinical milestones over near-term debt service.
Negative Factors
Pre-revenue with persistent operating losses
Sustained pre-revenue losses indicate the business is not yet generating operating income and remains dependent on external capital to fund R&D. Over months, this structural lack of revenue constrains reinvestment capacity and forces prioritization of programs based on funding availability rather than organic cash flow.
Read all positive and negative factors
Positive Factors
Negative Factors
Low leverage / net-cash posture
An essentially debt-free, net-cash balance sheet materially reduces solvency and interest-rate risk for a pre-revenue biotech. This structural strength lengthens operational flexibility and runway versus leveraged peers, allowing management to prioritize clinical milestones over near-term debt service.
Read all positive factors
Phio Pharmaceuticals (PHIO) vs. SPDR S&P 500 ETF (SPY)
Market Cap
$11.91M
Dividend YieldN/A
Average Volume (3M)1.12M
Price to Earnings (P/E)―
Beta (1Y)2.36
Revenue GrowthN/A
EPS Growth77.90%
CountryUS
Employees6
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)-1.43
Shares Outstanding11,617,250
10 Day Avg. Volume2,961,356
30 Day Avg. Volume1,116,732
Financial Highlights & Ratios
PEG Ratio-0.01
Price to Book (P/B)0.31
Price to Sales (P/S)0.00
P/FCF Ratio-0.79
Enterprise Value/Market Cap>-0.01
Enterprise Value/RevenueN/A
Enterprise Value/Gross Profit<0.01
Enterprise Value/Ebitda<0.01
Forecast
1Y Price Target
$14.00Price Target Upside1246.15% Upside
Rating ConsensusModerate Buy
Number of Analyst Covering1
EPS Forecast (FY)-1.38
Revenue Forecast (FY)N/A
Phio Pharmaceuticals Business Overview & Revenue Model
Company Description
Phio Pharmaceuticals Corp., a clinical stage biopharmaceutical company, engages in the development of immuno-oncology therapeutics in the United States. It develops PH-762, an INTASYL compound designed to reduce the expression of PD-1 in multi-cen...
How the Company Makes Money
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Phio Pharmaceuticals Financial Statement Overview
Summary
Income Statement
12
Very Negative
Balance Sheet
58
Neutral
Cash Flow
22
Negative
| Breakdown | TTM | Dec 2025 | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| Gross Profit | -3.73M | -4.62M | -3.64M | -6.33M | -7.01M | -8.89M |
| EBITDA | -10.93M | -8.70M | -7.15M | -10.64M | -11.41M | -13.21M |
| Net Income | -10.93M | -8.70M | -7.15M | -10.83M | -11.48M | -13.29M |
Balance Sheet | ||||||
| Total Assets | 17.41M | 21.49M | 5.74M | 9.36M | 12.81M | 25.17M |
| Cash, Cash Equivalents and Short-Term Investments | 17.03M | 21.03M | 5.38M | 8.49M | 11.78M | 24.06M |
| Total Debt | 0.00 | 0.00 | 0.00 | 35.00K | 170.00K | 295.00K |
| Total Liabilities | 950.00K | 1.34M | 1.01M | 1.63M | 1.97M | 3.24M |
| Stockholders Equity | 16.46M | 20.15M | 4.72M | 7.73M | 10.84M | 21.93M |
Cash Flow | ||||||
| Free Cash Flow | -10.72M | -7.99M | -7.11M | -10.75M | -12.25M | -11.91M |
| Operating Cash Flow | -10.71M | -7.98M | -7.11M | -10.75M | -12.13M | -11.86M |
| Investing Cash Flow | -7.00K | -12.00K | 8.00K | -5.00K | -121.00K | -51.00K |
| Financing Cash Flow | 14.47M | 23.64M | 4.00M | 7.41M | -26.00K | 21.72M |
Phio Pharmaceuticals Technical Analysis
Negative
1.04
Price Trends
1.05
Negative
1.13
Negative
1.22
Negative
Market Momentum
<0.01
Negative
49.79
Neutral
72.22
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For PHIO, the sentiment is Negative. The current price of 1.04 is above the 20-day moving average (MA) of 1.03, below the 50-day MA of 1.05, and below the 200-day MA of 1.22, indicating a bearish trend. The MACD of <0.01 indicates Negative momentum. The RSI at 49.79 is Neutral, neither overbought nor oversold. The STOCH value of 72.22 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for PHIO.
Phio Pharmaceuticals Risk Analysis
Phio Pharmaceuticals disclosed 23 risk factors in its most recent earnings report. Phio Pharmaceuticals reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks
Phio Pharmaceuticals Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
49 Neutral | $11.91M | -0.72 | -77.34% | ― | ― | 77.90% | |
46 Neutral | $69.55M | -2.43 | -53.86% | ― | -20.00% | 75.26% | |
44 Neutral | $4.90M | -0.36 | 937.72% | ― | -72.74% | 48.64% | |
41 Neutral | $5.22M | -0.17 | -423.84% | ― | -8.47% | 25.61% | |
39 Underperform | $13.48K | >-0.01 | -5612.86% | ― | ― | 99.09% |
* Healthcare Sector Average
PHIO
Phio Pharmaceuticals
1.03
-1.35
-56.75%
IBIO
Ibio
1.40
0.77
121.17%
EVGN
Evogene
0.47
-0.72
-60.42%
WINT
Windtree Therapeutics
0.01
-0.57
-97.93%
BRTX
BioRestorative Therapies
0.20
-1.28
-86.22%
Phio Pharmaceuticals Corporate Events
Business Operations and StrategyExecutive/Board Changes
Phio Pharmaceuticals adds dermatology expert to board
Positive
Jul 21, 2026
Effective July 20, 2026, Phio Pharmaceuticals increased its Board of Directors to six members and appointed dermatologist and clinical researcher R. Todd Plott, M.D. as a director and Governance Committee member through the 2026 annual meeting. Pl...
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.