Quarterly and Sequential Revenue Growth
Q4 2025 revenue of $44.6M, up 14% year-over-year and 16% quarter-over-quarter, driven by increased Revio and Vega sales and record consumables.
Record Consumables Performance
Consumables reached another record in Q4 with revenue of $21.6M (Q4 consumables +15% YoY). Full-year consumables were $82M, up 16% YoY, and consumable shipments grew 19% in 2025. Clinical & hospital consumables grew 55% in 2025.
Improved Gross Margins
Non-GAAP gross margin improved to 40% in Q4 and full-year 2025 (from 31% Q4 2024 and 33% full-year 2024). Management cites a 1,300 basis point improvement since 2023 and a 700 basis point improvement in 2025 alone.
Instrument Placements and Platform Momentum
Q4 shipments included 21 Revio and 42 Vega systems, bringing cumulative shipments to 331 Revio and 147 Vega systems. Vega showed strong order trends, with ~65% of 2025 Vega placements to new-to-PacBio customers, expanding HiFi adoption.
SparkNex Chemistry and Multi-use SMRT Cell Progress
SparkNex beta results reported 25% higher output per SMRT Cell and higher yields/read quality vs prior chemistry. Company targets whole-genome HiFi sequencing at scale for under $300 per genome and plans broader launch in 2026.
Clinical and Population Sequencing Traction
Notable clinical initiatives (University of Washington, Ambry ONCE study enrolling ~1,000 in 2026, IHOPE inclusion, Babies in Focus) and large population projects (All of Us publication, Long Life Family Study, Asian Pan-Genome) demonstrating adoption and pipeline.
Operating Expense and Cash Burn Improvements
Non-GAAP operating expenses reduced to $229.9M in 2025 (from $289.2M in 2024; 20% YoY reduction). Cash burn (ex-financings/acquisitions) improved from $214M in 2023 to $105M in 2025 (51% improvement since 2023; 44% YoY).
Balance Sheet Strengthening
Sale of short-read sequencing assets produced ~ $48M net proceeds and the company ended 2025 with approximately $279.5M in unrestricted cash, cash equivalents, and investments, extending runway and focusing resources on long-read strategy.