Strong Top-Line Revenue Growth
Revenue grew 56% year-over-year in Q1 2026 compared to Q1 2025; updated full-year revenue guidance raised by $2 billion at each end to $82 billion–$85 billion (midpoint = ~28% growth vs 2025).
Major Contribution from Key Products (Incretin & Others)
Combined global revenue for Mounjaro and Suven was $12.8 billion in Q1, contributing $6.7 billion of growth vs Q1 2025; key products collectively grew by more than $7 billion year-over-year.
Outstanding Prescriptions and International Momentum
U.S. incretin analog total prescriptions grew >80% in Q1; international incretin market increased 77% YoY (IQVIA gross sales). Mounjaro achieved strong international uptake, with average OUS market share above 53% and market share ~60% in select markets (e.g., Korea).
Record Earnings and Margin Improvement
Non-GAAP EPS was $8.55 in Q1 2026 versus $3.34 in Q1 2025. Non-GAAP performance margin was 50%, an increase of ~7 percentage points year-over-year. Gross margin was 82.6% of revenue (down ~1 percentage point YoY).
Foundayo (oral GLP-1) U.S. Approval and Early Launch Traction
Foundayo (orforgopron) approved by U.S. FDA for obesity and launched in April 2026; early commercial indicators include broad pharmacy availability (April 9), availability on >12 major telehealth platforms, confirmation of commercial access at 2 of 3 largest PBMs (mid-May), >8,000 prescribers (≈1/3 new to class), and >20,000 patients treated to date with 80% of prescriptions new-to-class.
Positive Clinical and Pipeline Milestones
Multiple positive Phase III results: Foundayo ACHIEVE I (cardiovascular safety: 16% lower MACE risk; secondary 23% lower risk; exploratory 57% lower all-cause death not controlled for multiplicity), positive TRANSCEND P2D-1 for retatrutide (A1c lowered 1.7–2.0 percentage points; weight loss 11.1–16.6 kg / 25–37 lbs), positive data in CLL for pertibrutinib, pediatric atopic dermatitis, and combination results (ixekizumab + tirzepatide). Company has 42 active Phase III programs and initiated multiple new Phase III programs across therapeutic areas.
Active Business Development and Portfolio Expansion
Announced/acquired multiple strategic transactions including Orna Therapeutics, Syntessa, Colonia Therapeutics, Ajax Therapeutics, Ventix Biosciences, and Contessa Pharmaceuticals to expand capabilities in in vivo CAR-T, sleep-wake disorders, next-gen JAK inhibitors, NLRP3 inhibitors, and orexin receptor agonists.
Capital Returns and Shareholder Discipline
Distributed $1.5 billion in dividends and executed $2.4 billion in share repurchases in Q1; company increased FY non-GAAP EPS guidance to $35.50–$37 (up $2 at both ends) and reiterated commitment to disciplined BD to create shareholder value.