Strong ARCALYST Revenue Growth
Q1 2026 ARCALYST net revenue of $214.3 million, up 56% year-over-year (≈+$76 million vs Q1 2025) and approximately $12 million higher than Q4 2025.
Raised Full-Year Revenue Guidance
Full-year 2026 revenue guidance raised to $930 million–$945 million from prior $900 million–$920 million, reflecting confidence in continued commercial momentum.
Improving Profitability and Cash Generation
Net income increased to $22.6 million in Q1 2026 versus $8.5 million in Q1 2025. Ended Q1 with $468.1 million cash balance and $54 million net cash generation for the period; company expects to remain cash-flow positive on an annual basis under current plan.
Collaboration Profit Expansion
ARCALYST collaboration profit grew 73% year-over-year to $151.2 million in Q1 2026, outpacing revenue growth.
Commercial Execution — Prescriber and Patient Adoption
Approximately 400 new prescribers wrote ARCALYST for the first time in Q1 (highest quarterly increase since launch), bringing total prescribers to >4,550; ~1,320 prescribers are repeat prescribers. Highest-ever quarter-on-quarter increase in new patient enrollments since launch.
Targeted Direct-to-Consumer (DTC) Launch
Initiated 'Heart's Home' targeted DTC campaign leveraging digital and AI approaches (connected TV, social media, search optimization). Management cites internal data that when patients inquire about ARCALYST, prescribers write it ~80% of the time, indicating high conversion potential from increased patient awareness.
Pipeline Progress — KPL-387 and KPL-1161 Milestones
KPL-387 integrated Phase II/III program: Phase II dose-focusing data on track for second half of 2026 and Phase III initiation expected by year-end 2026. KPL-1161 (Fc‑modified IL‑1α/β inhibitor) advancing toward Phase I planned by year-end 2026. KPL-387 formulation supports once-monthly dosing and single-syringe administration, enabling potential autoinjector development.