Chiome Bioscience Inc.
Chiome Bioscience Inc. is a global company dedicated to the research and development of cutting-edge technology platforms for drug discovery. Its operations are structured into two primary divisions: the Drug Discovery Business and the Drug Discovery Support Business. The company offers key proprietary technologies, including the ADLib System, a platform for generating monoclonal antibodies essential for drug discovery and development, and the Human ADLib System, which engineers chicken antibody genes into humanized therapeutic antibodies. Additionally, Chiome Bioscience provides a range of support services, such as protein expression and purification, stable cell line generation for recombinant protein and antibody production, and bespoke antibody generation utilizing either its ADLib system or B cell cloning techniques. Chiome Bioscience boasts a robust product pipeline with several candidates currently in Phase 1 clinical trials. These include: ADCT-701: an anti-dlk1 antibody targeting liver cancer. CBA-1205: an afucosylated anti-dlk1 antibody indicated for liver cancer, lung cancer, and neuroblastoma. CBA-1535: an anti-5T4/WAIF1 antibody for malignant mesothelioma, small cell lung cancer (SCLC), non-small cell lung cancer (NSCLC), and triple-negative breast cancer (TNBC). Furthermore, its preclinical pipeline features: LIV-2008/2008b: an anti-TROP-2 antibody aimed at treating TNBC, lung cancer, and colorectal cancer. BMAA: an anti-semaphorin3a antibody for central nervous system, immune/inflammatory, neurological, and ophthalmic diseases. PCDC: an anti-CDCP1 antibody targeting lung, colorectal, pancreatic, breast, and ovarian tumors. PTRY: a multi-specific 5T4/CD3/PD-L1 antibody designed for malignant mesothelioma, SCLC, NSCLC, and triple-negative breast cancer. PFKR: an anti-CX3CR1 antibody focused on secondary progressive multiple sclerosis. The company's services and technologies benefit a diverse clientele, including universities, research institutions, and pharmaceutical companies. Established in 2005, Chiome Bioscience Inc. maintains its headquarters in Tokyo, Japan.