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iSpecimen (ISPC)
NASDAQ:ISPC
US Market

iSpecimen (ISPC) AI Stock Analysis

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ISPC

iSpecimen

(NASDAQ:ISPC)

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Neutral 41 (OpenAI - 5.2)
Rating:41Neutral
Price Target:
$0.36
▲(15.81% Upside)
The score is weighed down primarily by weak financial performance (sharp TTM revenue decline, margin deterioration, ongoing losses, and persistent cash burn). Technicals add a mixed-to-weak backdrop (below key longer-term moving averages with negative MACD). Corporate events and valuation provide limited offset given Nasdaq bid-price compliance risk and a negative P/E tied to ongoing losses.
Positive Factors
Platform and Network
iSpecimen’s technology-driven marketplace and broad provider partnerships create durable sourcing advantages for rare and diverse biospecimens. Network effects and institutional relationships support recurring demand from pharma and academia, improving long-term sample access and customer stickiness.
Low Financial Leverage
Very low debt (debt-to-equity ~0.09) reduces solvency risk and preserves financial flexibility. This structural conservatism allows the company to pursue operational fixes or raise capital on less strained terms over the next several months, a durable mitigant to business stress.
Recent Capital Raise
The $5.5M Series C private placement materially improves near-term liquidity and extends runway, enabling continued operations, sample sourcing, and investor outreach. As a structural financing event, it reduces immediate refinancing urgency over the next few months.
Negative Factors
Sharp Revenue Decline
A ~43% TTM revenue drop signals weakening customer demand or loss of contracts, eroding scale and operating leverage. Sustained top-line decline undermines ability to cover fixed costs and invest in growth, increasing the risk that recovery will require structural changes or new commercial wins.
Margin Compression
Gross margin roughly halved year-over-year, indicating either pricing pressure or higher procurement/fulfillment costs. This structural margin deterioration reduces cash generation per sale and means revenue recovery must be substantially larger to restore profitability and fund operations sustainably.
Persistent Cash Burn
Consistent negative operating cash flow (~-$6.8M TTM) shows the core business consumes cash, forcing reliance on financing. Persistent burn increases dilution and restricts investment in product, compliance, or partnerships, making liquidity a central medium-term fundamental risk.

iSpecimen (ISPC) vs. SPDR S&P 500 ETF (SPY)

iSpecimen Business Overview & Revenue Model

Company DescriptioniSpecimen Inc. provides technology that connects life science researchers who need human biofluids, tissues, and living cells for their research with biospecimens available in healthcare provider organizations worldwide. Its cloud-based technology enables scientists to search for specimens and patients across a network of hospitals, labs, biobanks, blood centers, and other healthcare organizations. The company develops and operates iSpecimen Marketplace, a proprietary online marketplace platform that connects medical researchers who need access to subjects, samples, and data with hospitals, laboratories, and other organizations who have access to them. It serves biopharmaceutical companies, in vitro diagnostic companies, and government/academic institutions. The company was incorporated in 2009 and is headquartered in Lexington, Massachusetts.
How the Company Makes MoneyiSpecimen generates revenue primarily through the sale of human biospecimens and associated data to researchers, pharmaceutical companies, and academic institutions. The company's revenue model is built on fees charged for the procurement and delivery of biospecimens, which can vary based on the type and quantity of samples requested. Key revenue streams include transactions for individual biospecimen orders, long-term supply agreements with biopharma companies, and collaborative projects that may involve custom sample collection services. Additionally, iSpecimen has established strategic partnerships with hospitals, clinics, and biobanks, enhancing its access to a wide array of biospecimens and driving growth in its revenue through increased sample availability and diversity.

iSpecimen Financial Statement Overview

Summary
Fundamentals are weak overall: TTM revenue declined sharply (-43.3%), margins deteriorated (gross margin ~21.6% vs. ~42.9% in 2024), and the company remains unprofitable. Cash flow is a major negative with consistently negative operating cash flow (TTM ~-$6.8M) and negative free cash flow, despite low leverage (debt-to-equity ~0.09) providing some balance-sheet flexibility.
Income Statement
18
Very Negative
TTM (Trailing-Twelve-Months) revenue fell sharply (-43.3%), pointing to meaningful top-line pressure versus the relatively modest declines seen in prior annual periods. Profitability remains weak: the company is still generating operating losses and net losses, and margins deteriorated significantly in TTM (gross margin ~21.6% vs. ~42.9% in 2024). The main positive is that gross profit is still positive, but overall earnings power and trajectory are currently unfavorable.
Balance Sheet
44
Neutral
Leverage is low across periods (debt-to-equity ~0.09 in TTM and 2024), which reduces financial risk and gives some balance-sheet flexibility. However, equity has trended down materially since 2022, and returns to shareholders are deeply negative (return on equity is strongly negative in TTM), reflecting ongoing losses and a weakening capital base over time. Overall, the balance sheet is not highly levered, but it is being pressured by persistent unprofitability.
Cash Flow
12
Very Negative
Cash generation is a key concern: operating cash flow is negative in every period shown, including TTM (approximately -$6.8M), indicating the core business is consuming cash rather than producing it. Free cash flow is also consistently negative, and while TTM free cash flow improved versus the prior annual period, it remains meaningfully below zero. The company’s cash burn profile increases financing risk if conditions do not improve.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue3.35M9.29M9.93M10.40M11.14M8.18M
Gross Profit722.54K3.99M5.11M5.65M5.89M4.60M
EBITDA-9.47M-12.73M-8.80M-8.80M-5.86M-1.74M
Net Income-11.53M-12.50M-11.10M-10.25M-8.96M-4.65M
Balance Sheet
Total Assets9.00M9.35M15.82M24.62M35.72M6.21M
Cash, Cash Equivalents and Short-Term Investments2.78M1.88M5.01M15.31M27.74M695.91K
Total Debt281.44K312.17K196.24K185.85K3.42M12.77M
Total Liabilities5.92M6.04M6.08M4.31M5.93M33.49M
Stockholders Equity3.07M3.31M9.74M20.31M29.79M-27.28M
Cash Flow
Free Cash Flow-6.79M-8.30M-10.55M-9.01M-11.71M-1.39M
Operating Cash Flow-6.76M-8.26M-5.81M-5.82M-10.67M-288.38K
Investing Cash Flow-1.07M1.98M-7.23M-3.19M-1.04M-1.10M
Financing Cash Flow8.86M5.82M70.89K-3.42M38.75M2.03M

iSpecimen Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price0.31
Price Trends
50DMA
0.38
Negative
100DMA
0.68
Negative
200DMA
0.90
Negative
Market Momentum
MACD
-0.01
Negative
RSI
48.09
Neutral
STOCH
30.75
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For ISPC, the sentiment is Neutral. The current price of 0.31 is below the 20-day moving average (MA) of 0.35, below the 50-day MA of 0.38, and below the 200-day MA of 0.90, indicating a neutral trend. The MACD of -0.01 indicates Negative momentum. The RSI at 48.09 is Neutral, neither overbought nor oversold. The STOCH value of 30.75 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for ISPC.

iSpecimen Risk Analysis

iSpecimen disclosed 72 risk factors in its most recent earnings report. iSpecimen reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

iSpecimen Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
48
Neutral
$10.24M
46
Neutral
$9.56M-0.43-223.45%3.26%65.96%
45
Neutral
$5.71M-0.05-245.18%-27.66%13.18%
41
Neutral
$3.33M-0.04-296.20%-67.73%58.35%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
ISPC
iSpecimen
0.33
-1.72
-83.80%
INBS
Intelligent Bio Solutions
7.41
-9.59
-56.41%
BGLC
BioNexus Gene Lab Corp
2.65
-1.16
-30.45%
MYNZ
Mainz Biomed B.V.
1.13
-6.17
-84.52%
BIAF
bioAffinity Technologies, Inc.
1.07
-22.17
-95.40%

iSpecimen Corporate Events

Shareholder Meetings
iSpecimen Reschedules 2025 Annual Meeting Amid Quorum Issues
Negative
Jan 27, 2026

iSpecimen Inc. convened its 2025 Annual Meeting of Stockholders on December 31, 2025, but the meeting was adjourned twice—first on December 31 and again when reconvened on January 23, 2026—because the company failed to achieve a quorum of shareholders. The company now plans to reconvene the delayed 2025 Annual Meeting on February 13, 2026, with the record date remaining November 3, 2025, highlighting ongoing challenges in securing sufficient shareholder participation to vote on proxy proposals and finalize annual governance matters.

The most recent analyst rating on (ISPC) stock is a Hold with a $0.31 price target. To see the full list of analyst forecasts on iSpecimen stock, see the ISPC Stock Forecast page.

Shareholder Meetings
iSpecimen Postpones Annual Meeting Due to Lack Quorum
Neutral
Jan 5, 2026

On December 31, 2025, iSpecimen Inc. convened its 2025 annual meeting of stockholders but adjourned it after failing to achieve a quorum of shareholders needed to conduct business on the proposals previously circulated. The company plans to reconvene the annual meeting on January 23, 2026, maintaining November 3, 2025 as the record date, signaling an effort to secure sufficient shareholder participation to move forward with its proposed agenda.

The most recent analyst rating on (ISPC) stock is a Sell with a $0.28 price target. To see the full list of analyst forecasts on iSpecimen stock, see the ISPC Stock Forecast page.

Business Operations and StrategyPrivate Placements and Financing
iSpecimen Completes Private Placement, Engages IR Consulting Firm
Positive
Jan 5, 2026

On December 31, 2025, iSpecimen Inc. completed a private placement of its Series C Convertible Non-Voting Preferred Stock and entered into a Consulting Agreement with IR Agency LLC to provide marketing, advertising, and investor communications services for an initial four-month term starting the same day. The consultant, acting as an independent contractor on a non-exclusive basis, received a $2 million cash fee funded from the private placement proceeds, and the agreement—which includes standard contractual protections and can be terminated at any time by either party—signals iSpecimen’s effort to strengthen its market visibility and investor outreach without engaging in securities solicitation activities.

The most recent analyst rating on (ISPC) stock is a Sell with a $0.28 price target. To see the full list of analyst forecasts on iSpecimen stock, see the ISPC Stock Forecast page.

Private Placements and Financing
iSpecimen raises capital via new Series C preferred
Neutral
Jan 2, 2026

On December 30, 2025, iSpecimen Inc. entered into a Securities Purchase Agreement with accredited investors to issue 6,875 shares of newly created Series C Convertible Non-Voting Preferred Stock, each with a stated value of $1,000 and sold at $800 per share, and on December 31, 2025 closed the transaction for aggregate gross proceeds of $5.5 million. The Series C preferred shares, which were structured to rank senior to common stock in dividends and liquidation and carry no general voting rights, are convertible into common shares at 85% of the prior trading day’s closing price, subject to a floor price, and were sold in a private placement under Regulation D, with iSpecimen granting investors registration rights for the resale of conversion shares and appointing E.F. Hutton & Co. as exclusive placement agent, a move that strengthens the company’s capital position but introduces potential future equity dilution for existing shareholders.

The most recent analyst rating on (ISPC) stock is a Sell with a $0.28 price target. To see the full list of analyst forecasts on iSpecimen stock, see the ISPC Stock Forecast page.

Delistings and Listing ChangesRegulatory Filings and Compliance
iSpecimen Regains Nasdaq Compliance as of November 2025
Positive
Dec 1, 2025

On November 28, 2025, iSpecimen Inc. received confirmation from the Nasdaq Listing Qualifications Staff that it now meets the continued listing requirements under Nasdaq Listing Rules. Previously, on June 4, 2025, the company was notified of non-compliance with the minimum stockholders’ equity, market value of listed securities, or net income requirements. However, as of September 30, 2025, iSpecimen reported stockholders’ equity of $3,072,711, regaining compliance and closing the matter.

The most recent analyst rating on (ISPC) stock is a Sell with a $0.40 price target. To see the full list of analyst forecasts on iSpecimen stock, see the ISPC Stock Forecast page.

Delistings and Listing ChangesRegulatory Filings and Compliance
iSpecimen Faces Nasdaq Delisting Notice for Stock Price
Negative
Nov 21, 2025

On November 19, 2025, iSpecimen Inc. received a notice from Nasdaq indicating that its common stock had fallen below the minimum bid price requirement of $1.00 per share for 30 consecutive business days, putting the company out of compliance with Nasdaq’s listing rules. The company has until May 18, 2026, to regain compliance by achieving a closing bid price of at least $1.00 per share for ten consecutive business days. If compliance is not regained, iSpecimen may seek an additional compliance period or face potential delisting, with options including a reverse stock split to address the deficiency.

The most recent analyst rating on (ISPC) stock is a Sell with a $0.50 price target. To see the full list of analyst forecasts on iSpecimen stock, see the ISPC Stock Forecast page.

Executive/Board Changes
iSpecimen Appoints Katharyn Field as New CEO
Neutral
Nov 7, 2025

On November 7, 2025, iSpecimen Inc. announced significant leadership changes with the appointment of Ms. Katharyn Field as Chief Executive Officer, Secretary, and Treasurer, succeeding Mr. Robert Bradley Lim who resigned from these roles and the Board. Ms. Field, who has been serving as President since February 2025, brings extensive experience in strategy consulting and executive leadership, particularly in the cannabis industry. Additionally, Mr. Arphing (Tommy) Lee was appointed as an independent director, joining the Audit and Nominating and Corporate Governance Committees. The company emphasized that these leadership changes are not expected to disrupt operations, and the Board remains focused on executing the company’s objectives.

The most recent analyst rating on (ISPC) stock is a Hold with a $1.00 price target. To see the full list of analyst forecasts on iSpecimen stock, see the ISPC Stock Forecast page.

Private Placements and FinancingRegulatory Filings and ComplianceShareholder MeetingsStock Split
iSpecimen Approves Key Proposals in Stockholder Meeting
Positive
Nov 3, 2025

On October 30, 2025, iSpecimen Inc. held a special meeting of stockholders to vote on several key proposals. The company successfully approved a reverse stock split, an increase in authorized shares, and amendments related to private financing transactions and convertible securities, all of which are aimed at enhancing its financial flexibility and compliance with Nasdaq rules.

The most recent analyst rating on (ISPC) stock is a Hold with a $1.00 price target. To see the full list of analyst forecasts on iSpecimen stock, see the ISPC Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jan 28, 2026