Broad Development And Market RisksMultiple risk factors including potential clinical setbacks, regulatory delays, commercial adoption challenges, financing shortfalls, and intellectual property disputes could materially affect program progress and valuation.
Concentration Of Near-term Value On Few ReadoutsReliance on a small number of pivotal trial readouts for most of the company's near-term value concentrates downside risk if those studies fail or produce ambiguous results, increasing stock volatility.
Small Or Concentrated Patient PopulationsSome indications have small or geographically concentrated patient populations, which could limit commercial scale and make partnering necessary for successful commercialization.