Patient Population SizeSome target indications involve small or geographically concentrated patient populations, which could limit commercial scale and dampen revenue potential even if therapies are approved.
Program And Financing Risk ExposureThe company faces multiple risks across clinical development, regulatory review, intellectual property, and financing that could lead to delays, additional capital needs, or unfavorable outcomes for valuation.
Reliance On Partnerships For CommercializationNarrow indications and limited market size may necessitate partnerships for commercial launch, potentially reducing future revenue share and strategic control over product rollouts.