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Shield Therapeutics PLC (GB:STX)
LSE:STX
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Shield Therapeutics (STX) AI Stock Analysis

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GB:STX

Shield Therapeutics

(LSE:STX)

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Neutral 57 (OpenAI - 4o)
Rating:57Neutral
Price Target:
6.50p
▼(-2.26% Downside)
The overall stock score is primarily influenced by the company's robust technical performance, indicating strong market momentum. However, significant financial weaknesses, including negative profitability and cash flow issues, weigh heavily on the score. Valuation concerns due to a negative P/E ratio and lack of dividend yield further impact the stock's attractiveness.
Positive Factors
Revenue Growth
Strong revenue growth demonstrates the company's ability to expand its market presence and increase product adoption, which is crucial for long-term sustainability and competitiveness in the pharmaceutical industry.
Product Focus
A clear focus on iron deficiency treatments positions Shield Therapeutics as a specialist in a niche market, potentially leading to a strong competitive advantage and brand recognition in this therapeutic area.
Cash Flow Management
Improved cash flow management indicates better operational efficiency and financial discipline, which are essential for sustaining business operations and funding future growth initiatives.
Negative Factors
Negative Profitability
Persistent negative profitability poses a significant challenge, as it can hinder the company's ability to reinvest in growth opportunities and may require external financing to sustain operations.
Balance Sheet Weakness
Negative equity indicates financial distress and potential insolvency risk, limiting the company's ability to secure favorable financing terms and invest in strategic initiatives.
High Leverage
High leverage can strain financial resources and increase vulnerability to economic downturns, potentially impacting long-term financial stability and operational flexibility.

Shield Therapeutics (STX) vs. iShares MSCI United Kingdom ETF (EWC)

Shield Therapeutics Business Overview & Revenue Model

Company DescriptionShield Therapeutics plc, a specialty pharmaceutical company, engages in the development and commercialization of clinical stage pharmaceuticals to treat unmet medical needs. The company's lead product is Accrufer/Feraccru, a non-salt based oral therapy for the treatment of iron deficiency with or without anemia in adults. It also develops PT20, a novel iron-based phosphate binder that has completed its Phase II pivotal study for the treatment of hyperphosphatemia in patients with chronic kidney disease. The company was founded in 2008 and is based in Gateshead, the United Kingdom.
How the Company Makes MoneyShield Therapeutics generates revenue primarily through the sale of its lead product, Accrufer, which is marketed to healthcare providers and patients in various markets. The company may also explore licensing agreements and partnerships with other pharmaceutical firms to expand its market reach and enhance distribution channels. Additionally, Shield Therapeutics could benefit from collaborations in clinical trials or research initiatives that lead to new product developments or indications, thereby creating further revenue opportunities. The effectiveness of its marketing strategies and the demand for its products play crucial roles in driving its earnings.

Shield Therapeutics Financial Statement Overview

Summary
Despite strong revenue growth, Shield Therapeutics faces severe financial challenges with negative profitability, cash flow issues, and a strained balance sheet characterized by negative equity and high leverage.
Income Statement
35
Negative
The company has shown significant revenue growth, with total revenue increasing from 1.5 million in 2021 to 25.2 million in 2024, representing a strong growth trajectory. However, the net profit margin remains deeply negative due to substantial net losses, and both EBIT and EBITDA margins are negative, indicating ongoing operational challenges and profitability issues.
Balance Sheet
28
Negative
The balance sheet reflects a negative stockholders' equity as of 2024, indicating financial distress and a potential risk of insolvency. The debt-to-equity ratio is high due to negative equity, and the equity ratio is also negative, highlighting a critical situation in terms of financial stability and leverage.
Cash Flow
40
Negative
Free cash flow remains negative, although there is a small improvement in operating cash flow. The free cash flow to net income ratio is negative, indicating cash flow problems. However, the company has managed to reduce the magnitude of negative operating cash flow compared to previous years, showing a slight improvement in cash management.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue32.07M25.18M13.09M5.50M1.52M10.39M
Gross Profit14.32M10.57M4.03M2.00M539.00K9.03M
EBITDA-9.93M-16.58M-30.29M-46.07M-17.69M820.00K
Net Income-16.42M-21.27M-33.29M-40.44M-19.34M-2.63M
Balance Sheet
Total Assets62.10M45.90M48.80M22.07M44.41M32.53M
Cash, Cash Equivalents and Short-Term Investments10.81M5.61M13.95M2.82M12.12M2.94M
Total Debt27.05M21.06M20.25M6.10M156.00K28.00K
Total Liabilities76.96M46.95M26.49M16.65M3.38M2.25M
Stockholders Equity-14.86M-1.05M11.79M5.43M40.69M30.28M
Cash Flow
Free Cash Flow-8.15M-7.03M-40.07M-20.14M-18.80M-1.42M
Operating Cash Flow-8.15M-7.01M-37.13M-18.25M-16.74M-1.40M
Investing Cash Flow-1.30M-1.89M-2.43M-1.70M-2.05M-20.00K
Financing Cash Flow11.83M4.21M49.66M7.71M27.58M-47.00K

Shield Therapeutics Technical Analysis

Technical Analysis Sentiment
Neutral
Last Price6.65
Price Trends
50DMA
7.63
Negative
100DMA
5.77
Positive
200DMA
4.31
Positive
Market Momentum
MACD
-0.22
Positive
RSI
38.14
Neutral
STOCH
26.47
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For GB:STX, the sentiment is Neutral. The current price of 6.65 is below the 20-day moving average (MA) of 7.59, below the 50-day MA of 7.63, and above the 200-day MA of 4.31, indicating a neutral trend. The MACD of -0.22 indicates Positive momentum. The RSI at 38.14 is Neutral, neither overbought nor oversold. The STOCH value of 26.47 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Neutral sentiment for GB:STX.

Shield Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
£4.02B13.7115.66%3.46%3.73%27.13%
£70.61M-3.58-396.71%93.48%51.18%
£173.16M-7.082.83%2.07%8.74%-166.50%
£531.23M4.50%74.32%
$7.86B-0.30-43.30%2.27%22.53%-2.21%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
GB:STX
Shield Therapeutics
6.65
3.85
137.50%
GB:AGY
Allergy Therapeutics
8.65
3.15
57.27%
GB:ANCR
Animalcare
251.00
17.81
7.64%
GB:HIK
Hikma Pharmaceuticals
1,839.00
42.75
2.38%
GB:BXP
Beximco Pharmaceuticals Limited Sponsored GDR RegS
43.00
13.47
45.61%

Shield Therapeutics Corporate Events

Business Operations and StrategyFinancial Disclosures
Shield Therapeutics Achieves Record Quarterly Performance with ACCRUFeR®
Positive
Oct 23, 2025

Shield Therapeutics reported its strongest quarterly performance to date, with a 15% increase in ACCRUFeR® prescriptions over the previous quarter, achieving net revenues of $13.1 million. The company remains on track to become cash flow positive by the end of 2025, driven by strategic marketing initiatives and strong sales efforts, marking a significant milestone in its operational progress.

The most recent analyst rating on (GB:STX) stock is a Buy with a £0.10 price target. To see the full list of analyst forecasts on Shield Therapeutics stock, see the GB:STX Stock Forecast page.

Business Operations and StrategyExecutive/Board Changes
Shield Therapeutics Grants Share Options to CEO Amidst Strategic Growth
Positive
Oct 14, 2025

Shield Therapeutics announced the grant of share options to its CEO, Anders Lundstrom, as part of the company’s Retention and Performance Share Plan. This move is part of Lundstrom’s annual equity grant, with options granted over 1,547,262 ordinary shares. The grant reflects Shield’s commitment to retaining key leadership as it continues to focus on its market-leading product, ACCRUFeR®, which addresses a significant unmet need in iron deficiency treatment. The company’s strategic positioning in the pharmaceutical industry is reinforced by its global licensing agreements and the growing market opportunity for its flagship product.

The most recent analyst rating on (GB:STX) stock is a Buy with a £0.10 price target. To see the full list of analyst forecasts on Shield Therapeutics stock, see the GB:STX Stock Forecast page.

Product-Related AnnouncementsRegulatory Filings and Compliance
Shield Therapeutics Announces Share Capital and Market Position of ACCRUFeR®
Positive
Oct 1, 2025

Shield Therapeutics has announced that its total issued share capital consists of 1,061,802,812 ordinary shares, each with equal voting rights, as per FCA’s Disclosure and Transparency Rule. The company’s flagship product, ACCRUFeR®, is the first FDA-approved oral iron treatment for iron deficiency, representing a significant market opportunity and addressing unmet medical needs.

The most recent analyst rating on (GB:STX) stock is a Hold with a £6.50 price target. To see the full list of analyst forecasts on Shield Therapeutics stock, see the GB:STX Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Shield Therapeutics Reports Positive Pediatric Trial Results for Ferric Maltol
Positive
Oct 1, 2025

Shield Therapeutics announced positive results from its Phase 3 pediatric trial of ferric maltol, presented at the American Association of Pediatrics Conference. The study demonstrated significant improvements in hemoglobin levels and a favorable safety profile, marking an important milestone for expanding ACCRUFeR®’s use in young children. This development could enhance Shield’s market position by addressing a critical unmet need for safe and effective oral iron treatments in pediatric populations.

The most recent analyst rating on (GB:STX) stock is a Hold with a £6.50 price target. To see the full list of analyst forecasts on Shield Therapeutics stock, see the GB:STX Stock Forecast page.

Business Operations and StrategyPrivate Placements and Financing
Shield Therapeutics Raises £1.5 Million to Boost ACCRUFeR® Growth
Positive
Sep 15, 2025

Shield Therapeutics has successfully raised £1.5 million through a placing of new ordinary shares, driven by unsolicited institutional investor demand, to support the growth of its leading product, ACCRUFeR®, in the U.S. market. This financial move, which involved issuing shares at a premium, aims to strengthen the company’s working capital and broaden its shareholder base, positioning Shield to accelerate sales and achieve positive cash flow by the end of 2025.

The most recent analyst rating on (GB:STX) stock is a Hold with a £6.50 price target. To see the full list of analyst forecasts on Shield Therapeutics stock, see the GB:STX Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Shield Therapeutics’ ACCRUFeR® Receives FDA Priority Review for Pediatric Use
Positive
Sep 4, 2025

Shield Therapeutics has announced that the FDA has accepted ACCRUFeR®/FeRACCRU® for Priority Review to extend its indication to adolescents with iron deficiency anemia, with approval anticipated in 2026. This development follows successful Phase 3 trials and could significantly expand the patient base, offering a novel oral treatment option for both adolescents and potentially adults who have difficulty swallowing capsules.

The most recent analyst rating on (GB:STX) stock is a Hold with a £6.50 price target. To see the full list of analyst forecasts on Shield Therapeutics stock, see the GB:STX Stock Forecast page.

Business Operations and StrategyFinancial Disclosures
Shield Therapeutics Reports Strong H1 2025 Results and Global Expansion
Positive
Sep 3, 2025

Shield Therapeutics reported a significant increase in revenues and prescription sales for the first half of 2025, driven by the strong performance of its product ACCRUFeR® in the U.S. and global markets. The company achieved substantial progress in international partnerships, including new licensing agreements and regulatory submissions, while maintaining its guidance to become cash flow positive by the end of 2025. These developments highlight Shield’s strategic efforts to expand its market presence and meet the growing demand for its iron deficiency treatment.

The most recent analyst rating on (GB:STX) stock is a Hold with a £6.50 price target. To see the full list of analyst forecasts on Shield Therapeutics stock, see the GB:STX Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Shield Therapeutics Reports Positive Results for Ferric Maltol in Heart Failure Patients
Positive
Aug 27, 2025

Shield Therapeutics announced positive results from the ORION-HF study, which demonstrated significant improvements in haemoglobin levels, exercise capacity, and quality of life for patients with heart failure and iron deficiency anemia treated with FeRACCRU® (ferric maltol). These findings, published in the European Journal of Heart Failure, highlight the potential of ferric maltol as an effective oral alternative to intravenous iron therapies, addressing a significant unmet need in the treatment of heart failure. The study’s results are consistent with previous research and could enhance Shield’s market positioning and stakeholder interest in the therapeutic benefits of ACCRUFeR®/FeRACCRU®.

The most recent analyst rating on (GB:STX) stock is a Hold with a £6.50 price target. To see the full list of analyst forecasts on Shield Therapeutics stock, see the GB:STX Stock Forecast page.

Business Operations and StrategyFinancial DisclosuresProduct-Related Announcements
Shield Therapeutics Reports Strong H1 2025 Results and Global Expansion
Positive
Aug 21, 2025

Shield Therapeutics reported a significant increase in revenues and prescription sales for the first half of 2025, driven by the strong performance of its product ACCRUFeR® in the U.S. and successful global partnerships. The company achieved a 1.8x growth in total revenues to $21.4 million and narrowed its losses significantly, with a positive outlook to turn cash flow positive by the end of 2025. Key developments include the launch of ACCRUFeR® in Canada, a new licensing agreement in Japan, and progress in regulatory submissions for pediatric use in Europe and the U.S. These advancements position Shield Therapeutics favorably in the iron deficiency treatment market, potentially expanding access to patients worldwide.

The most recent analyst rating on (GB:STX) stock is a Hold with a £6.50 price target. To see the full list of analyst forecasts on Shield Therapeutics stock, see the GB:STX Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Aug 19, 2025