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Shield Therapeutics PLC (GB:STX)
LSE:STX

Shield Therapeutics (STX) AI Stock Analysis

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GB:STX

Shield Therapeutics

(LSE:STX)

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Neutral 63 (OpenAI - 5.2)
Rating:63Neutral
Price Target:
10.50p
▲(6.60% Upside)
The overall stock score is primarily influenced by the company's robust technical momentum and positive corporate events, which are offset by significant financial challenges and valuation concerns. The strong technical indicators and strategic corporate developments provide optimism, but financial instability remains a critical risk.
Positive Factors
Accelerating Revenue Growth
Sustained, large revenue expansion indicates growing commercial traction for Accrufer and successful market penetration. This scale-up supports recurring sales and distributor relationships, strengthening franchise value and providing a base to leverage fixed costs over time, improving long-term economics.
Positive Corporate Developments
Debt amendments and regulatory/clinical progress are structural positives: amended financing can extend runway and reduce near-term default risk, while trial and approval advances de-risk pipeline commercialization and expand addressable markets, improving long-term strategic optionality.
Clear Specialty Focus and Distribution
A focused specialty model with a single differentiated product targeting unmet needs creates a durable niche advantage. Direct sales plus distributor partnerships enable scalable patient access and formulary uptake, supporting sustainable revenue growth if clinical benefits and prescribing persist.
Negative Factors
Negative Equity and High Leverage
Negative equity and elevated leverage are structural solvency concerns that limit financing options, raise refinancing risk, and can trigger covenants or creditor actions. Over time this constrains investment, M&A, and R&D, forcing priority on liquidity over growth execution.
Persistent Negative Free Cash Flow
Ongoing negative free cash flow indicates the business consumes cash to operate and scale. Reliance on external financing to fund operations is structurally risky, can dilute shareholders or increase leverage, and limits the firm's ability to self-fund commercialization and long-term R&D.
Deep Negative Profitability
Large operating losses despite revenue growth signal structural margin pressure—high SG&A, COGS or R&D burn. Without clear path to sustained positive operating margins, profitability depends on scale, cost control, or pricing shifts, making long-term earnings uncertain.

Shield Therapeutics (STX) vs. iShares MSCI United Kingdom ETF (EWC)

Shield Therapeutics Business Overview & Revenue Model

Company DescriptionShield Therapeutics plc, a specialty pharmaceutical company, engages in the development and commercialization of clinical stage pharmaceuticals to treat unmet medical needs. The company's lead product is Accrufer/Feraccru, a non-salt based oral therapy for the treatment of iron deficiency with or without anemia in adults. It also develops PT20, a novel iron-based phosphate binder that has completed its Phase II pivotal study for the treatment of hyperphosphatemia in patients with chronic kidney disease. The company was founded in 2008 and is based in Gateshead, the United Kingdom.
How the Company Makes MoneyShield Therapeutics generates revenue through the sale of its core product, Accrufer, which is marketed to healthcare providers and institutions. The company employs a direct sales model as well as partnerships with distributors and wholesalers to reach a wider market. Additionally, revenue is supported by collaborations with other pharmaceutical firms that may include licensing agreements, co-promotion deals, or research partnerships aimed at developing new formulations or expanding market reach. The effectiveness of its sales strategies, coupled with increasing awareness and demand for its iron treatments, contributes significantly to the company's earnings.

Shield Therapeutics Financial Statement Overview

Summary
Despite strong revenue growth, Shield Therapeutics faces severe financial challenges with negative profitability, cash flow issues, and a strained balance sheet characterized by negative equity and high leverage.
Income Statement
The company has shown significant revenue growth, with total revenue increasing from 1.5 million in 2021 to 25.2 million in 2024, representing a strong growth trajectory. However, the net profit margin remains deeply negative due to substantial net losses, and both EBIT and EBITDA margins are negative, indicating ongoing operational challenges and profitability issues.
Balance Sheet
The balance sheet reflects a negative stockholders' equity as of 2024, indicating financial distress and a potential risk of insolvency. The debt-to-equity ratio is high due to negative equity, and the equity ratio is also negative, highlighting a critical situation in terms of financial stability and leverage.
Cash Flow
Free cash flow remains negative, although there is a small improvement in operating cash flow. The free cash flow to net income ratio is negative, indicating cash flow problems. However, the company has managed to reduce the magnitude of negative operating cash flow compared to previous years, showing a slight improvement in cash management.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue32.07M25.18M13.09M5.50M1.52M10.39M
Gross Profit14.32M10.57M4.03M2.00M539.00K9.03M
EBITDA-9.93M-16.58M-30.29M-46.07M-17.69M820.00K
Net Income-16.42M-21.27M-33.29M-40.44M-19.34M-2.63M
Balance Sheet
Total Assets62.10M45.90M48.80M22.07M44.41M32.53M
Cash, Cash Equivalents and Short-Term Investments10.81M5.61M13.95M2.82M12.12M2.94M
Total Debt27.05M21.06M20.41M6.10M156.00K28.00K
Total Liabilities76.96M46.95M26.49M16.65M3.38M2.25M
Stockholders Equity-14.86M-1.05M11.79M5.43M40.69M30.28M
Cash Flow
Free Cash Flow-8.15M-7.03M-40.07M-20.14M-18.80M-1.42M
Operating Cash Flow-8.15M-7.01M-37.13M-18.25M-16.74M-1.40M
Investing Cash Flow-1.30M-1.89M-2.43M-1.70M-2.05M-20.00K
Financing Cash Flow11.83M4.21M49.66M7.71M27.58M-47.00K

Shield Therapeutics Technical Analysis

Technical Analysis Sentiment
Positive
Last Price9.85
Price Trends
50DMA
9.10
Positive
100DMA
8.37
Positive
200DMA
5.73
Positive
Market Momentum
MACD
0.23
Positive
RSI
53.90
Neutral
STOCH
41.67
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For GB:STX, the sentiment is Positive. The current price of 9.85 is below the 20-day moving average (MA) of 10.61, above the 50-day MA of 9.10, and above the 200-day MA of 5.73, indicating a neutral trend. The MACD of 0.23 indicates Positive momentum. The RSI at 53.90 is Neutral, neither overbought nor oversold. The STOCH value of 41.67 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for GB:STX.

Shield Therapeutics Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
75
Outperform
£3.47B12.1515.66%4.16%3.73%27.13%
65
Neutral
£84.57M
63
Neutral
£111.49M-5.65-396.71%93.48%51.18%
57
Neutral
£730.83M-14.17-0.28%22.94%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
GB:STX
Shield Therapeutics
10.50
8.15
346.81%
GB:AGY
Allergy Therapeutics
11.90
4.54
61.68%
GB:HIK
Hikma Pharmaceuticals
1,574.00
-369.36
-19.01%
GB:VLG
Venture Life
67.00
29.50
78.67%

Shield Therapeutics Corporate Events

Regulatory Filings and Compliance
Shield Therapeutics Confirms Total Voting Rights and Share Capital Structure
Neutral
Jan 2, 2026

Shield Therapeutics has confirmed that its issued share capital comprises 1,067,828,251 ordinary shares, each carrying equal voting rights and with no shares held in treasury, establishing the official share count that investors must use when calculating notifiable holdings under UK disclosure and transparency rules. The clarification of total voting rights provides greater transparency for shareholders and regulators, supporting accurate reporting of significant stakes in the company as it continues to commercialise its flagship iron deficiency treatment ACCRUFeR/FeRACCRU globally.

The most recent analyst rating on (GB:STX) stock is a Hold with a £12.00 price target. To see the full list of analyst forecasts on Shield Therapeutics stock, see the GB:STX Stock Forecast page.

Business Operations and StrategyProduct-Related AnnouncementsRegulatory Filings and Compliance
Shield Therapeutics Wins FDA Nod to Extend ACCRUFeR Use to Adolescents
Positive
Dec 22, 2025

Shield Therapeutics has secured U.S. Food and Drug Administration approval to extend the indication for its oral iron therapy ACCRUFeR (ferric maltol) to include pediatric patients aged 10 years and older, following a priority review supported by positive Phase 3 pediatric trial data. The company plans to seek a further indication expansion to cover children from 1 month of age using a new ferric maltol suspension formulation, which could also benefit adults unable to swallow capsules, strengthening ACCRUFeR’s clinical reach and reinforcing Shield’s position in the growing iron deficiency market.

The most recent analyst rating on (GB:STX) stock is a Hold with a £12.00 price target. To see the full list of analyst forecasts on Shield Therapeutics stock, see the GB:STX Stock Forecast page.

Business Operations and StrategyDelistings and Listing Changes
Shield Therapeutics Announces Block Listing Application to London Stock Exchange
Positive
Dec 18, 2025

Shield Therapeutics has applied for a block listing of 15,000,000 ordinary shares to the London Stock Exchange, which will be allocated to the company’s Retention and Performance Share Plan and admitted to trading on 23 December 2025. The application aligns with the company’s focus on iron deficiency treatments, notably ACCRUFeR®, positioning Shield Therapeutics as a leader in this $2.3 billion market, while enhancing operational flexibility and rewarding key personnel to support further growth.

The most recent analyst rating on (GB:STX) stock is a Hold with a £12.00 price target. To see the full list of analyst forecasts on Shield Therapeutics stock, see the GB:STX Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Shield Therapeutics Wins Gold at Titan Branding Awards for ACCRUFeR®
Positive
Dec 11, 2025

Shield Therapeutics has been awarded Gold at the 2025 Titan Brand Awards for the rebranding of its product ACCRUFeR®, highlighting its effective brand strategy and communication in the competitive pharmaceutical market. This recognition underscores ACCRUFeR®’s position as a leading brand in the iron deficiency market, where it serves a significant unmet medical need, and marks the beginning of Shield’s digital marketing initiative aimed at further growth.

The most recent analyst rating on (GB:STX) stock is a Hold with a £12.00 price target. To see the full list of analyst forecasts on Shield Therapeutics stock, see the GB:STX Stock Forecast page.

M&A TransactionsPrivate Placements and Financing
Shield Therapeutics Strengthens Financial Position with Amended Debt Financing
Positive
Dec 3, 2025

Shield Therapeutics has amended its senior secured debt financing, enhancing its financial position by increasing available funds to $50 million, with $15 million earmarked for future mergers and acquisitions. The revised terms, achieved through collaboration with SWK Holdings and Runway Growth Finance, lower debt costs and extend the interest-only period, providing Shield with greater flexibility to pursue growth opportunities and strengthen its market position in the pharmaceutical industry.

The most recent analyst rating on (GB:STX) stock is a Hold with a £8.50 price target. To see the full list of analyst forecasts on Shield Therapeutics stock, see the GB:STX Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Shield Therapeutics Advances ACCRUFeR® Clinical Trials in Japan for PAH
Positive
Nov 14, 2025

Shield Therapeutics announced the initiation of a Phase II clinical trial in Japan for ACCRUFeR® (ferric maltol) as a treatment for Pulmonary Arterial Hypertension (PAH). This trial, conducted by its partner MEDLEAP Pharma, aims to support a Phase III trial and potential regulatory submissions by 2028. The development is significant as it addresses the challenges of long-term iron supplementation in PAH patients, potentially positioning ACCRUFeR® as a core treatment in this field.

The most recent analyst rating on (GB:STX) stock is a Buy with a £0.10 price target. To see the full list of analyst forecasts on Shield Therapeutics stock, see the GB:STX Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Shield Therapeutics to Present Pediatric PK Results at ASH Conference
Positive
Nov 11, 2025

Shield Therapeutics announced the presentation of pediatric pharmacokinetic results for ferric maltol at the upcoming American Society of Hematology Conference. The study confirmed the suitability of ferric maltol for iron replacement in children, supporting its potential expansion to younger populations and highlighting its importance in addressing unmet medical needs in pediatric iron deficiency treatment.

The most recent analyst rating on (GB:STX) stock is a Buy with a £0.10 price target. To see the full list of analyst forecasts on Shield Therapeutics stock, see the GB:STX Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Shield Therapeutics’ ACCRUFeR® Gains Approval in South Korea
Positive
Nov 7, 2025

Shield Therapeutics has announced that its product, ACCRUFeR®, has received marketing authorization from the Korean Ministry of Food and Drug Safety for treating iron deficiency in adults. This approval, following a successful pharmacokinetic study and new drug application by Korea Pharma, signifies a major advancement in expanding ACCRUFeR®’s availability in South Korea. Shield is set to receive payments and royalties from sales in the region, reinforcing its commitment to global patient access and highlighting the strength of its international partnerships.

The most recent analyst rating on (GB:STX) stock is a Buy with a £0.10 price target. To see the full list of analyst forecasts on Shield Therapeutics stock, see the GB:STX Stock Forecast page.

Business Operations and StrategyFinancial Disclosures
Shield Therapeutics Achieves Record Quarterly Performance with ACCRUFeR®
Positive
Oct 23, 2025

Shield Therapeutics reported its strongest quarterly performance to date, with a 15% increase in ACCRUFeR® prescriptions over the previous quarter, achieving net revenues of $13.1 million. The company remains on track to become cash flow positive by the end of 2025, driven by strategic marketing initiatives and strong sales efforts, marking a significant milestone in its operational progress.

The most recent analyst rating on (GB:STX) stock is a Buy with a £0.10 price target. To see the full list of analyst forecasts on Shield Therapeutics stock, see the GB:STX Stock Forecast page.

Business Operations and StrategyExecutive/Board Changes
Shield Therapeutics Grants Share Options to CEO Amidst Strategic Growth
Positive
Oct 14, 2025

Shield Therapeutics announced the grant of share options to its CEO, Anders Lundstrom, as part of the company’s Retention and Performance Share Plan. This move is part of Lundstrom’s annual equity grant, with options granted over 1,547,262 ordinary shares. The grant reflects Shield’s commitment to retaining key leadership as it continues to focus on its market-leading product, ACCRUFeR®, which addresses a significant unmet need in iron deficiency treatment. The company’s strategic positioning in the pharmaceutical industry is reinforced by its global licensing agreements and the growing market opportunity for its flagship product.

The most recent analyst rating on (GB:STX) stock is a Buy with a £0.10 price target. To see the full list of analyst forecasts on Shield Therapeutics stock, see the GB:STX Stock Forecast page.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 07, 2025