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Roquefort Investments PLC (GB:ROQ)
LSE:ROQ
US Market

Roquefort Investments PLC (ROQ) AI Stock Analysis

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GB:ROQ

Roquefort Investments PLC

(LSE:ROQ)

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Neutral 44 (OpenAI - 5.2)
Rating:44Neutral
Price Target:
1.50p
▲(25.00% Upside)
The score is primarily held back by weak financial fundamentals (pre-commercial revenue volatility, ongoing losses and cash burn). Technical indicators also point to a sustained downtrend. Low leverage on the balance sheet provides some support, but the negative P/E and lack of dividend yield limit valuation appeal.

Roquefort Investments PLC (ROQ) vs. iShares MSCI United Kingdom ETF (EWC)

Roquefort Investments PLC Business Overview & Revenue Model

Company DescriptionRoquefort Therapeutics plc operates as a biotechnology research company. The company engages in the research and development of drugs targeting Midkine, a circulating growth factor protein and pro-inflammatory mediator for the treatment of cancer. Roquefort Therapeutics plc was incorporated in 2020 and is headquartered in London, the United Kingdom.
How the Company Makes Money

Roquefort Investments PLC Financial Statement Overview

Summary
Income Statement
12
Very Negative
Balance Sheet
56
Neutral
Cash Flow
25
Negative
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue0.000.00200.00K0.00719.00
Gross Profit-2.70K-16.00K200.00K0.00-9.35K
EBITDA-926.73K-1.11M-1.93M0.00-352.40K
Net Income-882.45K-971.80K-1.74M-1.62M-917.43K
Balance Sheet
Total Assets5.66M5.75M6.09M7.77M4.56M
Cash, Cash Equivalents and Short-Term Investments182.92K337.11K537.32K2.32M899.72K
Total Debt383.65K400.09K0.000.000.00
Total Liabilities909.12K861.73K589.02K561.58K477.43K
Stockholders Equity4.75M4.89M5.50M7.21M4.08M
Cash Flow
Free Cash Flow-645.62K-783.73K-1.79M-1.58M-2.62M
Operating Cash Flow-588.75K-783.73K-1.73M-1.58M-2.62M
Investing Cash Flow-57.06K0.00-52.57K-103.48K-1.11M
Financing Cash Flow236.00K584.91K-58.003.10M4.63M

Roquefort Investments PLC Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
55
Neutral
£314.67M9.4515.04%1231.50%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
47
Neutral
£27.61M-5.79-202.14%23.76%
44
Neutral
£1.88M-1.80-18.71%
44
Neutral
£15.06M-9.38-164.37%-11.43%23.40%
43
Neutral
£5.75M-5.18-433.59%
42
Neutral
£229.72M
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
GB:ROQ
Roquefort Investments PLC
1.35
-2.60
-65.82%
GB:AVCT
Avacta Group plc
54.50
8.00
17.20%
GB:CIZ
Cizzle Biotechnology Holdings PLC
1.45
-0.40
-21.62%
GB:PRTC
PureTech Health
135.00
-1.40
-1.03%
GB:SAR
Sareum Holdings
19.50
-3.50
-15.22%
GB:FAB
Fusion Antibodies Plc
13.50
4.50
50.00%

Roquefort Investments PLC Corporate Events

Business Operations and Strategy
Roquefort Therapeutics Flags New Broker Research on Coiled and A2A Deal
Positive
Jan 15, 2026

Roquefort Therapeutics has announced that its broker, SP Angel Corporate Finance, has published a new research note analysing the company’s proposed transaction with clinical-stage oncology firm Coiled Therapeutics and AI-driven drug discovery specialist A2A Pharmaceuticals. The note, now available via Roquefort’s website, is expected to give investors further insight into the strategic rationale for the deal, which links Roquefort to Coiled’s brain-penetrant cancer candidate AO-252 already in Phase I trials, and to A2A’s generative AI-enabled SCULPT platform and proven spin-out model, potentially strengthening Roquefort’s position in oncology drug development and long-term value creation.

The most recent analyst rating on (GB:ROQ) stock is a Sell with a £1.50 price target. To see the full list of analyst forecasts on Roquefort Investments PLC stock, see the GB:ROQ Stock Forecast page.

Business Operations and StrategyProduct-Related Announcements
Roquefort Therapeutics Extends AO-252 License Agreement Amid Clinical Trial Progress
Positive
Dec 12, 2025

Roquefort Therapeutics PLC announced an amendment to its exclusive license agreement with Coiled Therapeutics, Inc. and A2A Pharmaceuticals, Inc. for the AO-252 drug, extending the long stop date to March 16, 2026. The amendment reflects significant progress in the Phase I clinical trial, which has expanded to include all solid tumors and prioritized prostate cancer. This strategic focus is supported by promising pre-clinical data and positive feedback from potential partners, highlighting the commercial interest in novel oral therapies for prostate cancer. The extension allows more time for data readouts and involves changes to the commercial terms, including an increase in consideration shares, underscoring the potential value of the AO-252 program.

Business Operations and StrategyPrivate Placements and Financing
Roquefort Therapeutics Converts Loan Notes into Shares, Expands Capital
Neutral
Dec 9, 2025

Roquefort Therapeutics has announced the conversion of £80,000 worth of convertible loan notes into 6,282,264 new ordinary shares. This conversion, which includes accrued interest, is part of the company’s financial strategy to manage its capital structure. The new shares will be admitted to trading on the London Stock Exchange, increasing the company’s total issued share capital to 163,726,294 ordinary shares. This move is significant for shareholders as it affects voting rights and shareholding calculations under regulatory rules.

Delistings and Listing Changes
Roquefort Therapeutics Announces Ex-Entitlement Date for Unlisted Shares
Neutral
Dec 1, 2025

Roquefort Therapeutics announced that its ordinary shares will be marked ex-entitlement for Unlisted Redeemable Non-Voting Shares as of December 1, 2025. Shareholders and convertible loan note holders registered by November 28, 2025, are eligible to receive these shares, with further details on the entitlement ratio and issuance to be announced later.

Other
Roquefort Therapeutics Sets Record Date for New Share Entitlement
Positive
Dec 1, 2025

Roquefort Therapeutics has announced the determination of the record date for entitlement to new unlisted redeemable non-voting shares, linked to its Midkine Investments portfolio. Shareholders and convertible loan note holders as of November 30, 2025, will be eligible for these shares, which aim to facilitate future distribution of Midkine Investments shares, enhancing shareholder value.

Business Operations and StrategyPrivate Placements and Financing
Roquefort Therapeutics MD Increases Stake with Major Share Purchase
Positive
Nov 24, 2025

Roquefort Therapeutics PLC announced that Dr. Darrin Disley, the Interim Managing Director, has purchased 5,000,000 ordinary shares of the company at an average price of 1.70 pence per share, amounting to a total consideration of £85,000. This acquisition increases Dr. Disley’s total shareholding to 7,024,196 shares, representing 4.46% of the company’s issued capital. This move could signal confidence in the company’s strategic direction and its ongoing efforts to acquire rights to a novel cancer treatment drug, potentially impacting its market positioning and stakeholder interests.

Business Operations and StrategyM&A TransactionsPrivate Placements and FinancingProduct-Related Announcements
Roquefort Therapeutics Secures Exclusive Rights to Novel Cancer Drug AO-252
Positive
Nov 18, 2025

Roquefort Therapeutics PLC has entered into a binding exclusive license agreement with Coiled Therapeutics, Inc. and A2A Pharmaceuticals, Inc. for the worldwide rights to AO-252, a first-in-class drug targeting TACC3 protein in multiple cancers. The agreement involves a reverse takeover and a proposed name change to Coiled Therapeutics PLC. The transaction includes an equity placing to raise funds for clinical trials and operational expansion. This strategic move aims to enhance Roquefort’s market position by advancing AO-252 through clinical stages, potentially benefiting up to 350,000 patients in the US and Europe, and achieving significant value milestones.

Business Operations and StrategyM&A Transactions
Roquefort Therapeutics Out-Licenses MK Cell Program and Updates on Lyramid Sale
Positive
Nov 3, 2025

Roquefort Therapeutics PLC has entered into an agreement to out-license its MK Cell patents to Pleiades Pharma Ltd, potentially earning up to $25 million in milestone payments and a royalty on sales. This strategic move is part of a broader group restructuring, which includes the sale of its subsidiary Lyramid Pty Ltd to Pleiades, contingent on successful fundraising. The restructuring aims to benefit existing shareholders and allow Roquefort to focus on a transformative acquisition with A2A Pharmaceuticals and Coiled Therapeutics, enhancing its position in the biotech industry.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jan 04, 2026