Stable Top-Line and Product Sales
Total revenues exceeded EUR 170 million in 2025, slightly above 2024; total product sales were EUR 157.9 million (down -3.3% y/y; -1.3% at constant currency).
Proprietary Product Growth
Proprietary product sales (ex-currency effects) grew ~+9% year-over-year; IXIARO sales increased to EUR 98.4 million (+4.6% y/y; +7.2% at constant currency).
Strong Cash Position and Financial Flexibility
Closed the year with nearly EUR 110 million in cash and completed a successful debt refinancing to enhance financial flexibility.
Material Reduction in Operating Cash Burn
Achieved more than a 20% reduction in operating cash burn through disciplined cash management and cost initiatives.
Progress on Key Clinical Programs — Lyme (VLA15)
VALOR Phase III (approx. 10,000 participants) completed vaccinations; top‑line Phase III readout guided for H1 2026 (Pfizer is study sponsor). Positive results described as potentially transformational.
Advancement of Other Pipeline Programs
Shigella S4V2 Phase II (infant and CHIM studies) ongoing with data expected mid‑2026; IXCHIQ pilot vaccination campaign launched in Brazil in Feb 2026 with 18–59 age group and targeted 20–40% coverage.
Cost Discipline in SG&A
Marketing & distribution expense decreased to EUR 37.4 million (from EUR 52.4M) and G&A decreased to EUR 37.3 million (from EUR 42.8M), reflecting reduced launch spend and administrative cost cuts.