Education
About Us
Working with TipRanks
Follow Us
Alnylam Pharmaceuticals (GB:0HD2)
LSE:0HD2
0HD2 Stock Chart & Stats
$400.37
-$1.89(-0.80%)
At close: 4:00 PM EST
$400.37
-$1.89(-0.80%)
Day’s Range― - ―
52-Week Range$209.75 - $500.21
Previous CloseN/A
Volume1.06K
Average Volume (3M)193.00
Market Cap
$52.92B
Enterprise Value$62.68B
Total Cash (Recent Filing)$2.72B
Total Debt (Recent Filing)$2.77B
Price to Earnings (P/E)1665.4
Beta0.29
Next Earnings
Feb 12, 2026EPS Estimate
1.27Next Dividend Ex-DateN/A
Dividend YieldN/A
Share Statistics
EPS (TTM)1.84
Shares Outstanding132,113,820
10 Day Avg. Volume241
30 Day Avg. Volume193
Financial Highlights & Ratios
PEG Ratio2.84
Price to Book (P/B)447.73
Price to Sales (P/S)13.36
P/FCF Ratio-705.29
Enterprise Value/Market Cap1.18
Enterprise Value/Revenue19.53
Enterprise Value/Gross Profit23.25
Enterprise Value/Ebitda336.00
Forecast
1Y Price Target
$497.37Price Target Upside24.23% Upside
Rating ConsensusStrong Buy
Number of Analyst Covering21
EPS Forecast (FY)N/A
Revenue Forecast (FY)N/A
Bulls Say, Bears Say
Bulls Say
Financial GuidanceAlnylam raised its 2025 total net product revenue guidance by $275 million, reflecting strong performance and growth expectations.
Growth And PerformanceAmvuttra script growth has been driven by TTR-CM approval.
Market ExpansionAmvuttra is now being used at the ~170 target health systems securing broad access for ATTR-CM patients.
Bears Say
Regulatory IssuesThe stock is under pressure from disclosure of a subpoena related to government price reporting.
Sales PerformanceAmvuttra sales are tracking slightly below consensus estimates.
Stock PerformanceShares of Alnylam closed weak, down around 7%, following the quarterly print, likely due to lofty investor expectations for Amvuttra sales.
Alnylam Pharma News
0HD2 FAQ
What was Alnylam Pharmaceuticals’s price range in the past 12 months?
Alnylam Pharmaceuticals lowest share price was $209.75 and its highest was $500.21 in the past 12 months.
What is Alnylam Pharmaceuticals’s market cap?
Alnylam Pharmaceuticals’s market cap is $52.92B.
When is Alnylam Pharmaceuticals’s upcoming earnings report date?
Alnylam Pharmaceuticals’s upcoming earnings report date is Feb 12, 2026 which is in 45 days.
How were Alnylam Pharmaceuticals’s earnings last quarter?
Alnylam Pharmaceuticals released its earnings results on Oct 30, 2025. The company reported $1.84 earnings per share for the quarter, beating the consensus estimate of $0.561 by $1.279.
Is Alnylam Pharmaceuticals overvalued?
According to Wall Street analysts Alnylam Pharmaceuticals’s price is currently Undervalued.
Does Alnylam Pharmaceuticals pay dividends?
Alnylam Pharmaceuticals pays a Notavailable dividend of $0.285 which represents an annual dividend yield of N/A. See more information on Alnylam Pharmaceuticals dividends here
What is Alnylam Pharmaceuticals’s EPS estimate?
Alnylam Pharmaceuticals’s EPS estimate is 1.27.
How many shares outstanding does Alnylam Pharmaceuticals have?
Alnylam Pharmaceuticals has 132,113,820 shares outstanding.
What happened to Alnylam Pharmaceuticals’s price movement after its last earnings report?
Alnylam Pharmaceuticals reported an EPS of $1.84 in its last earnings report, beating expectations of $0.561. Following the earnings report the stock price went down -6.875%.
Which hedge fund is a major shareholder of Alnylam Pharmaceuticals?
Currently, no hedge funds are holding shares in GB:0HD2
What is the TipRanks Smart Score and how is it calculated?
Smart Score combines eight research factors - such as analyst recommendations, hedge fund trends, and technical indicators - to measure a stock’s outlook. These signals are unified into a single score that reflects bullish or bearish momentum. See detailed methodology
Alnylam Pharma Stock Smart Score
Neutral
1
2
3
4
5
6
7
8
9
10
Analyst Consensus
Strong Buy
Average Price Target:
$497.37 (24.23% Upside)
$497.37 (24.23% Upside)
Blogger Sentiment
Bullish
GB:0HD2 Sentiment 100%
Sector Average 69%
Sector Average 69%
Insider Transactions
Sold Shares
Worth $8.8M over
the Last 3 Months
the Last 3 Months
Technicals
SMA
Positive
20 days / 200 days
Momentum
65.19%
12-Months-Change
Fundamentals
Return on Equity
32.73%
Trailing 12-Months
Asset Growth
15.38%
Trailing 12-Months
Company Description
Alnylam Pharmaceuticals
Alnylam Pharmaceuticals, Inc., a biopharmaceutical company, focuses on discovering, developing, and commercializing novel therapeutics based on ribonucleic acid interference. The company's pipeline of investigational RNAi therapeutics focuses on genetic medicines, cardio-metabolic diseases, hepatic infectious diseases, and central nervous system (CNS)/ocular diseases. Its marketed products include ONPATTRO (patisiran), a lipid complex injection for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults; GIVLAARI for the treatment of adults with acute hepatic porphyria (AHP); and OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1 (PH1). In addition, the company is developing givosiran for the treatment of adolescent patients with AHP; patisiran for the treatment of transthyretin amyloidosis, or ATTR amyloidosis, with cardiomyopathy; cemdisiran to treat complement-mediated diseases; ALN-AAT02 for the treatment of AAT deficiency-associated liver disease; ALN-HBV02 to treat chronic HBV infection; Zilebesiran to treat hypertension; and ALN-HSD to treat NASH. Further, it offers Fitusiran for the treatment of hemophilia and rare bleeding disorders, Inclisiran to treat hypercholesterolemia, lumasiran for the treatment of advanced PH1 and recurrent renal stones, and vutrisiran for the treatment of ATTR amyloidosis, which is in phase 3 clinical trial. Alnylam Pharmaceuticals, Inc. has strategic collaborations with Regeneron Pharmaceuticals, Inc. to discover, develop, and commercialize RNAi therapeutics for a range of diseases by addressing therapeutic targets expressed in the eye and CNS; and Sanofi Genzyme to discover, develop, and commercialize RNAi therapeutics. It also has license and collaboration agreements with Novartis AG; Vir Biotechnology, Inc.; Dicerna Pharmaceuticals, Inc.; Ionis Pharmaceuticals, Inc.; and PeptiDream, Inc. The company was founded in 2002 and is headquartered in Cambridge, Massachusetts.
0HD2 Company Deck
0HD2 Earnings Call
Q3 2025
0:00 / 0:00
Earnings Call Sentiment|Positive
The earnings call highlighted significant growth in the TTR franchise and strong pipeline advancements, with increased financial guidance indicating confidence in future performance. However, challenges remain with decreased gross margins and increased expenses, along with ongoing pricing negotiations in Europe.View all GB:0HD2 earnings summaries0HD2 Revenue Breakdown
67.90% Net product revenues
29.87% Net revenues from collaborations
2.22% Royalty revenue
0HD2 Stock 12 Month Forecast
Average Price Target
$497.37
▲(24.23% Upside)
Technical Analysis
Options Prices
Currently, No data available
---