Alnylam price target lowered to $444 from $508 at Stifel

Stifel analyst Paul Matteis lowered the firm’s price target on Alnylam (ALNY) to $444 from $508 and keeps a Buy rating on the shares. The firm notes that the quarter had little surprise after the company pre-reported and guided for both 2026 and 2030. As Stifel sees it, much of the weakness here looks overdone. The firm still sees TTR as a $10B-plus opportunity for Alnylam, and thinks the prior reaction to the 2030 margin profile was unfair given that this will be one of the peak years for the Vutri royalty which Stifel expects to come down substantially in the years following.