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Cellectis SA (FR:ALCLS)
:ALCLS
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Cellectis SA (ALCLS) AI Stock Analysis

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FR:ALCLS

Cellectis SA

(OTC:ALCLS)

Rating:56Neutral
Price Target:
€2.50
▼(-5.30% Downside)
Cellectis SA's overall stock score is primarily influenced by its challenging financial performance, with persistent losses and pressure on equity. Technical analysis provides a positive outlook with strong market momentum. Valuation remains a concern due to negative earnings, while the earnings call offers some optimism with strategic advancements and a solid cash position.

Cellectis SA (ALCLS) vs. iShares MSCI France ETF (EWQ)

Cellectis SA Business Overview & Revenue Model

Company DescriptionCellectis SA is a biotechnology company based in France that focuses on developing innovative therapies for cancer and genetic diseases using its proprietary gene-editing technology. The company specializes in the development of CAR-T cell therapies, which are designed to harness the power of the immune system to target and eliminate cancer cells. Cellectis operates primarily in the healthcare sector, with its core products and services centered around its unique gene-editing platform, UCART, and collaborations with various pharmaceutical companies to advance its therapies into clinical development.
How the Company Makes MoneyCellectis generates revenue primarily through partnerships and collaborations with other pharmaceutical and biotechnology companies. These partnerships often involve upfront payments, milestone payments associated with the achievement of specific development goals, and royalties on sales of products that result from their collaborations. Additionally, Cellectis may receive funding from government grants or research programs aimed at advancing biotechnology innovations. Its strategic collaborations with major players in the pharmaceutical industry, such as Pfizer and Servier, provide significant revenue opportunities through shared development costs and access to broader markets.

Cellectis SA Earnings Call Summary

Earnings Call Date:Aug 04, 2025
(Q2-2025)
|
% Change Since: -3.83%|
Next Earnings Date:Nov 10, 2025
Earnings Call Sentiment Positive
The earnings call highlighted significant progress in advancing pivotal clinical trials and maintaining a strong financial position, with ongoing collaborations and upcoming strategic events. However, ongoing arbitration and a decrease in cash reserves posed challenges.
Q2-2025 Updates
Positive Updates
Initiation of Pivotal Phase II Trial for lasme-cel
Cellectis is preparing to initiate the pivotal Phase II trial for lasme-cel (UCART22) in relapsed or refractory acute lymphoblastic leukemia in the second half of 2025, following successful end of Phase I discussions with the FDA and EMA.
Ongoing R&D Partnership with AstraZeneca
Research and development activities continue under the collaboration with AstraZeneca, focusing on three cell and gene therapy programs, including CAR-T for hematological malignancies, CAR-T for solid tumors, and in vivo gene therapy for a genetic disorder.
Strong Financial Position
Cellectis' cash, cash equivalents, and fixed-term deposits as of June 30, 2025, amount to $230 million, sufficient to fund operations into H2 2027.
Upcoming Investor R&D Day
Cellectis will host an Investor R&D Day on October 16, 2025, to present Phase I data and late-stage development strategy for lasme-cel.
Negative Updates
Servier Arbitration
Cellectis is engaged in arbitration with Servier regarding the termination of a licensing agreement, seeking compensation for losses due to lack of development of licensed products. The decision is expected by December 15, 2025.
Decrease in Cash and Equivalents
Cellectis reported a decrease of $33.2 million in cash and equivalents from December 31, 2024, to June 30, 2025, primarily due to operational expenses.
Company Guidance
During Cellectis' Second Quarter 2025 Earnings Call, the company provided guidance on several key metrics. They announced the completion of end-of-Phase I discussions with the FDA and EMA for lasme-cel, UCART22, in relapsed or refractory acute lymphoblastic leukemia, and their preparation to initiate a pivotal Phase II trial in the second half of 2025. Additionally, the NatHaLi-01 study on UCART20x22 is progressing, with Phase I data anticipated by late 2025. Cellectis is advancing three cell and gene therapy programs under their partnership with AstraZeneca. Financially, the company reported cash, cash equivalents, and fixed-term deposits of $230 million as of June 30, 2025, which are expected to fund operations into the second half of 2027. They are also involved in arbitration with Servier, with a decision expected by December 15, 2025. The company will provide further insights and data during their Investor R&D Day on October 16, 2025.

Cellectis SA Financial Statement Overview

Summary
Cellectis SA faces significant financial hurdles with persistent losses in income, although some progress is evident in cash flow improvements. The balance sheet reflects controlled leverage, yet equity is under pressure. For sustainable growth, Cellectis needs to focus on achieving profitability while managing its debt levels effectively.
Income Statement
38
Negative
Cellectis SA's income statement reflects a challenging financial position with a negative net profit margin and declining EBIT. Despite an increase in revenue in the TTM period, the company continues to struggle with profitability, as evidenced by the negative net income and EBITDA margins. Revenue growth shows potential, but persistent operating losses need addressing.
Balance Sheet
45
Neutral
The balance sheet of Cellectis SA displays a relatively stable equity position and an improving debt-to-equity ratio, indicating controlled leverage. However, the company faces a challenge with maintaining a positive equity ratio amidst high liabilities. The decrease in stockholders' equity over the past periods suggests potential financial strain, requiring close monitoring.
Cash Flow
50
Neutral
Cellectis SA shows improvement in cash flow management with a positive operating cash flow in the TTM period. Free cash flow has increased, albeit from a negative base, indicating better cash accrual from operations. However, the free cash flow to net income ratio indicates that net income remains negative, highlighting ongoing profitability challenges.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue56.30M41.51M755.00K19.17M73.95M73.95M
Gross Profit51.86M41.51M18.00K17.40M37.67M37.67M
EBITDA-30.25M-9.46M-92.64M-76.38M-85.44M-43.34M
Net Income-59.00M-36.76M-101.06M-98.69M-86.28M-72.57M
Balance Sheet
Total Assets353.97M383.54M334.27M261.22M382.08M469.47M
Cash, Cash Equivalents and Short-Term Investments196.15M260.31M203.81M97.70M186.13M268.24M
Total Debt94.77M91.46M85.06M82.85M102.24M111.30M
Total Liabilities256.86M252.51M249.57M135.28M145.60M160.63M
Stockholders Equity97.11M131.03M84.69M117.97M221.29M275.57M
Cash Flow
Free Cash Flow-36.60M19.15M-25.82M-89.89M-124.31M-126.52M
Operating Cash Flow-33.35M22.99M-24.75M-87.44M-104.56M-80.26M
Investing Cash Flow-42.82M-102.81M-15.51M-2.76M7.28M-54.34M
Financing Cash Flow-9.65M89.11M82.86M1.15M47.52M27.32M

Cellectis SA Technical Analysis

Technical Analysis Sentiment
Positive
Last Price2.64
Price Trends
50DMA
1.78
Positive
100DMA
1.56
Positive
200DMA
1.56
Positive
Market Momentum
MACD
0.22
Positive
RSI
65.33
Neutral
STOCH
65.12
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For FR:ALCLS, the sentiment is Positive. The current price of 2.64 is above the 20-day moving average (MA) of 2.40, above the 50-day MA of 1.78, and above the 200-day MA of 1.56, indicating a bullish trend. The MACD of 0.22 indicates Positive momentum. The RSI at 65.33 is Neutral, neither overbought nor oversold. The STOCH value of 65.12 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for FR:ALCLS.

Cellectis SA Peers Comparison

Overall Rating
UnderperformOutperform
Sector (50)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
56
Neutral
$183.12M-48.02%
50
Neutral
AU$2.63B3.1710.94%2.68%36.93%13.65%
49
Neutral
€103.70M-49.28%55.02%
48
Neutral
€330.70M
44
Neutral
€135.04M-220.48%-97.04%-32.53%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
FR:ALCLS
Cellectis SA
2.65
0.58
27.78%
FR:NANO
Nanobiotix
7.53
3.13
71.14%
FR:TNG
Transgene
1.03
<0.01
0.59%
FR:ALSEN
Sensorion SAS
0.35
-0.32
-47.92%

Cellectis SA Corporate Events

Cellectis Reports 2024 Financial Results and Strategic Advances in CAR T-Cell Therapies
Mar 13, 2025

Cellectis has announced its financial results for the fourth quarter and fiscal year 2024, alongside a business update. The company is advancing its clinical trials, particularly UCART22 and UCART20x22, with significant regulatory designations from the FDA and European Commission, enhancing its position in the CAR T-cell therapy market. Its strategic partnership with AstraZeneca, including a $140 million investment, supports the development of next-generation genomic medicines, with a strong cash position projected to last until mid-2027.

Cellectis Advances Clinical Programs and Strengthens AstraZeneca Partnership
Mar 13, 2025

Cellectis has reported its financial results for the fourth quarter and full year 2024, highlighting significant progress in its clinical programs and strategic partnerships. The company is advancing its UCART22 and UCART20x22 programs, with key data readouts expected in 2025. Cellectis has also strengthened its collaboration with AstraZeneca, which includes an additional equity investment of $140 million, ensuring financial stability until mid-2027. The company’s focus remains on developing next-generation genomic medicines to address unmet patient needs.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Aug 19, 2025