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Cellectis SA (FR:ALCLS)
:ALCLS
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Cellectis SA
(ALCLS)
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Rating:51Neutral
Price Target:
€4.00
▼(-2.91% Downside)
Cellectis SA's overall stock score reflects strong technical momentum but is weighed down by financial performance challenges and unattractive valuation metrics. The company's revenue growth is a positive factor, but significant profitability and cash flow issues, along with increased leverage, pose risks. The absence of earnings call data and corporate events means these factors do not influence the score.
Positive Factors
Revenue Growth
Significant revenue growth indicates strong sales momentum, suggesting increasing market acceptance and potential for future expansion.
Strategic Partnerships
Partnerships with major firms like AstraZeneca enhance R&D capabilities, potentially accelerating product development and market entry.
Financial Position
A strong cash position provides a buffer for operations and strategic initiatives, supporting long-term growth and stability.
Negative Factors
Profitability Challenges
Persistent profitability issues may hinder reinvestment in R&D and limit financial flexibility, impacting long-term growth potential.
Cash Flow Issues
Negative cash flow growth suggests difficulties in converting operations into cash, which could constrain future investments and expansion.
Increased Leverage
Higher leverage increases financial risk, potentially limiting the company's ability to secure additional funding if needed.
Cellectis SA (ALCLS) vs. iShares MSCI France ETF (EWQ)
Market Cap
$211.96M
Dividend YieldN/A
Average Volume (3M)852.48K
Price to Earnings (P/E)―
Beta (1Y)2.14
Revenue Growth150.80%
EPS Growth67.81%
CountryFR
Employees216
SectorHealthcare
Sector Strength45
IndustryBiotechnology
Share Statistics
EPS (TTM)<0.01
Shares Outstanding72,093,636
10 Day Avg. Volume1,338,181
30 Day Avg. Volume852,477
Financial Highlights & Ratios
PEG Ratio0.05
Price to Book (P/B)1.16
Price to Sales (P/S)3.65
P/FCF Ratio7.92
Enterprise Value/Market Cap0.27
Enterprise Value/Revenue0.75
Enterprise Value/Gross Profit0.83
Enterprise Value/Ebitda-9.32
Forecast
1Y Price TargetN/A
Price Target UpsideN/A
Rating ConsensusHold
Number of Analyst Covering0
EPS Forecast (FY)N/A
Revenue Forecast (FY)N/A
Cellectis SA Business Overview & Revenue Model
Company DescriptionCellectis S.A., a clinical stage biotechnological company, develops immuno-oncology products based on gene-edited T-cells that express chimeric antigen receptors to target and eradicate cancer cells. It operates through two segments, Therapeutics and Plants. The company is developing UCART19, an allogeneic T-cell product candidate for the treatment of CD19-expressing hematologic malignancies, such as acute lymphoblastic leukemia; ALLO-501 and ALLO-501A to treat relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma; ALLO-316 for the treatment of Renal Cell Carcinoma; UCART123 for the treatment of acute myeloid leukemia; and UCART22 to treat B-cell acute lymphoblastic leukemia. It is also developing UCARTCS1 and ALLO-715 for the treatment of multiple myeloma. The company has strategic alliances with Allogene Therapeutics, Inc.; Les Laboratoires Servier; The University of Texas M.D. Anderson Cancer Center; and Iovance Biotherapeutics, as well as a strategic research and development collaboration with Cytovia Therapeutics, Inc. Cellectis S.A. was founded in 1999 and is headquartered in Paris, France.
How the Company Makes MoneyCellectis generates revenue through a combination of research collaborations, licensing agreements, and potential milestone payments from partnerships with larger pharmaceutical companies. The company enters into strategic collaborations to leverage its gene editing technology for developing new therapies, which often includes upfront payments and milestone payments tied to achieving specific development goals. Additionally, Cellectis may earn royalties on any commercialized products that result from these partnerships. The company also focuses on advancing its proprietary product candidates, which could contribute to revenue streams through future sales once they reach the market.
Cellectis SA Earnings Call Summary
Earnings Call Date:Aug 04, 2025
(Q2-2025)
| % Change Since: |
Next Earnings Date:Mar 11, 2026
Earnings Call Sentiment Positive
The earnings call highlighted significant progress in advancing pivotal clinical trials and maintaining a strong financial position, with ongoing collaborations and upcoming strategic events. However, ongoing arbitration and a decrease in cash reserves posed challenges.Q2-2025 Updates
Positive Updates
Initiation of Pivotal Phase II Trial for lasme-cel
Cellectis is preparing to initiate the pivotal Phase II trial for lasme-cel (UCART22) in relapsed or refractory acute lymphoblastic leukemia in the second half of 2025, following successful end of Phase I discussions with the FDA and EMA.
Ongoing R&D Partnership with AstraZeneca
Research and development activities continue under the collaboration with AstraZeneca, focusing on three cell and gene therapy programs, including CAR-T for hematological malignancies, CAR-T for solid tumors, and in vivo gene therapy for a genetic disorder.
Strong Financial Position
Cellectis' cash, cash equivalents, and fixed-term deposits as of June 30, 2025, amount to $230 million, sufficient to fund operations into H2 2027.
Upcoming Investor R&D Day
Cellectis will host an Investor R&D Day on October 16, 2025, to present Phase I data and late-stage development strategy for lasme-cel.
Negative Updates
Servier Arbitration
Cellectis is engaged in arbitration with Servier regarding the termination of a licensing agreement, seeking compensation for losses due to lack of development of licensed products. The decision is expected by December 15, 2025.
Decrease in Cash and Equivalents
Cellectis reported a decrease of $33.2 million in cash and equivalents from December 31, 2024, to June 30, 2025, primarily due to operational expenses.
Company Guidance
During Cellectis' Second Quarter 2025 Earnings Call, the company provided guidance on several key metrics. They announced the completion of end-of-Phase I discussions with the FDA and EMA for lasme-cel, UCART22, in relapsed or refractory acute lymphoblastic leukemia, and their preparation to initiate a pivotal Phase II trial in the second half of 2025. Additionally, the NatHaLi-01 study on UCART20x22 is progressing, with Phase I data anticipated by late 2025. Cellectis is advancing three cell and gene therapy programs under their partnership with AstraZeneca. Financially, the company reported cash, cash equivalents, and fixed-term deposits of $230 million as of June 30, 2025, which are expected to fund operations into the second half of 2027. They are also involved in arbitration with Servier, with a decision expected by December 15, 2025. The company will provide further insights and data during their Investor R&D Day on October 16, 2025.Cellectis SA Financial Statement Overview
Summary
Cellectis SA shows revenue growth but faces significant profitability and cash flow challenges. The high gross profit margin indicates operational efficiency, yet negative net profit and EBIT margins highlight financial difficulties. Increased leverage and cash flow issues suggest a need for strategic adjustments.Income Statement
Cellectis SA shows a mixed performance in its income statement. The company has experienced significant revenue growth in the TTM period, with a 33.7% increase, indicating strong sales momentum. However, profitability remains a concern, as evidenced by negative net profit and EBIT margins, reflecting ongoing operational challenges. The gross profit margin is high at 92.11%, suggesting efficient cost management in production, but the overall negative margins highlight the need for better cost control and revenue generation strategies.45
Neutral
Balance Sheet
The balance sheet of Cellectis SA reveals a moderate financial position. The debt-to-equity ratio has increased to 0.98 in the TTM period, indicating higher leverage and potential risk if earnings do not improve. The equity ratio stands at 29.3%, showing a reasonable level of equity financing. However, the return on equity is negative, reflecting the company's inability to generate profits from its equity base. This suggests a need for strategic improvements to enhance shareholder value.40
Negative
Cash Flow
Cellectis SA's cash flow statement highlights challenges in cash generation. The free cash flow growth rate is negative, and the operating cash flow to net income ratio is also negative, indicating cash flow issues. Despite a positive free cash flow to net income ratio, the overall cash flow situation suggests the company struggles to convert its operations into cash, which could impact its ability to fund future growth without external financing.35
Negative
| Breakdown | TTM | Dec 2024 | Dec 2023 | Dec 2022 | Dec 2021 | Dec 2020 |
|---|---|---|---|---|---|---|
Income Statement | ||||||
| Total Revenue | 75.27M | 41.51M | 755.00K | 19.17M | 73.95M | 73.95M |
| Gross Profit | 68.47M | 41.51M | 18.00K | 17.40M | 37.67M | 37.67M |
| EBITDA | -6.07M | -9.46M | -92.64M | -76.38M | -85.44M | -43.34M |
| Net Income | -35.35M | -36.76M | -101.06M | -98.69M | -86.28M | -72.57M |
Balance Sheet | ||||||
| Total Assets | 343.05M | 383.54M | 334.27M | 261.22M | 382.08M | 469.47M |
| Cash, Cash Equivalents and Short-Term Investments | 52.24M | 260.31M | 203.81M | 97.70M | 186.13M | 268.24M |
| Total Debt | 37.58M | 91.46M | 85.06M | 82.85M | 102.24M | 111.30M |
| Total Liabilities | 242.57M | 252.51M | 249.57M | 135.28M | 145.60M | 160.63M |
| Stockholders Equity | 100.48M | 131.03M | 84.69M | 117.97M | 221.29M | 275.57M |
Cash Flow | ||||||
| Free Cash Flow | -32.71M | 19.15M | -25.82M | -89.89M | -124.31M | -126.52M |
| Operating Cash Flow | -29.09M | 22.99M | -24.75M | -87.44M | -104.56M | -80.26M |
| Investing Cash Flow | -68.60M | -102.81M | -15.51M | -2.76M | 7.28M | -54.34M |
| Financing Cash Flow | -9.70M | 89.11M | 82.86M | 1.15M | 47.52M | 27.32M |
Cellectis SA Technical Analysis
Positive
4.12
Price Trends
3.48
Positive
2.98
Positive
2.15
Positive
Market Momentum
0.25
Positive
56.87
Neutral
31.68
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For FR:ALCLS, the sentiment is Positive. The current price of 4.12 is above the 20-day moving average (MA) of 3.94, above the 50-day MA of 3.48, and above the 200-day MA of 2.15, indicating a bullish trend. The MACD of 0.25 indicates Positive momentum. The RSI at 56.87 is Neutral, neither overbought nor oversold. The STOCH value of 31.68 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for FR:ALCLS.
Cellectis SA Peers Comparison
UnderperformOutperform
Sector (51)
Name | Overall Rating | Market Cap | P/E Ratio | ROE | Dividend Yield | Revenue Growth | EPS Growth |
|---|---|---|---|---|---|---|---|
54 Neutral | €195.31M | -5.30 | ― | ― | 111.76% | -22.45% | |
51 Neutral | $7.86B | -0.30 | -43.30% | 2.27% | 22.53% | -2.21% | |
51 Neutral | $211.96M | -5.73 | -30.75% | ― | 150.80% | 67.81% | |
51 Neutral | €102.80M | -3.66 | -40.00% | ― | ― | 10.87% | |
49 Neutral | €832.03M | -23.55 | ― | ― | ― | ― | |
49 Neutral | €128.53M | -3.62 | -52.76% | ― | -96.92% | -175.84% | |
47 Neutral | €154.11M | ― | -271.32% | ― | -75.86% | -30.54% |
* Healthcare Sector Average
FR:ALCLS
Cellectis SA
4.12
2.28
124.03%
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-55.54%
Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
Disclaimer
This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.