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Cellectis SA (FR:ALCLS)
:ALCLS
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Cellectis SA (ALCLS) AI Stock Analysis

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Cellectis SA

(OTC:ALCLS)

Rating:51Neutral
Price Target:
€1.50
▼(-5.06%Downside)
Cellectis SA's overall stock score is weighed down by its challenging financial performance, marked by persistent losses and a negative P/E ratio. However, the technical analysis shows strong bullish momentum, providing some optimism. The lack of earnings call details and corporate events leaves a gap in qualitative assessment.

Cellectis SA (ALCLS) vs. iShares MSCI France ETF (EWQ)

Cellectis SA Business Overview & Revenue Model

Company DescriptionCellectis SA is a leading biopharmaceutical company specializing in the development of gene-editing technologies and therapies. Headquartered in Paris, France, the company operates primarily in the biotechnology and healthcare sectors. Cellectis is renowned for its pioneering work in developing allogeneic CAR-T cell therapies, which are designed to treat various types of cancer by leveraging advanced gene-editing techniques.
How the Company Makes MoneyCellectis SA generates revenue through a combination of product sales, licensing agreements, and collaboration partnerships. The company develops and commercializes gene-edited cell and gene therapies, particularly focusing on its allogeneic CAR-T cell products. Revenue streams include milestone payments and royalties from licensing its proprietary gene-editing technologies to other biotechnology and pharmaceutical companies. Additionally, Cellectis partners with major industry players to co-develop and commercialize therapies, sharing both the risks and the financial rewards. These collaborations often involve upfront payments, research funding, and potential future royalties upon successful commercialization of products.

Cellectis SA Earnings Call Summary

Earnings Call Date:May 12, 2025
(Q4-2024)
|
% Change Since: 17.04%|
Next Earnings Date:Jul 31, 2025
Earnings Call Sentiment Positive
The earnings call was largely positive, highlighting strategic collaboration, financial stability, and progress in clinical programs. However, challenges in ongoing arbitration and regulatory uncertainties were noted, but they did not overshadow the advancements and strategic gains made by the company.
Q4-2024 Updates
Positive Updates
Strategic Collaboration with AstraZeneca
Cellectis announced the start of R&D activities for three programs under their collaboration with AstraZeneca, including allogeneic CAR T for hematological malignancies, solid tumors, and an in vivo gene therapy. AstraZeneca completed an additional equity investment of $140 million, owning approximately 44% of Cellectis' share capital.
Financial Strength and Cash Runway
Cellectis' cash, cash equivalents, restricted cash, and fixed term deposits amounted to $264 million as of December 31, 2024, up from $156 million in 2023. The company is confident that their cash runway will fund operations into mid-2027.
UCART22 and UCART20x22 Progress
Cellectis received Orphan Drug Designation and Rare Pediatric Disease designation for UCART22. The company expects to present Phase 1 data for UCART22 in the third quarter of 2025 and for UCART20x22 in late 2025.
Manufacturing and Innovation
Cellectis showcased promising CAR T strategies targeting solid tumors using TALEN gene editing technology, presenting preclinical data at major conferences and publishing articles in scientific journals.
Negative Updates
Challenges in Servier Arbitration
Cellectis is involved in ongoing arbitration with Servier, limiting the company's ability to comment on potential outcomes.
Regulatory and Market Uncertainties
There are ongoing regulatory interactions required to align on Phase 2 registration strategies for UCART22 and UCART20x22, indicating potential uncertainties in development timelines.
Company Guidance
During the Cellectis Full Year 2024 Earnings Conference Call, the company provided guidance on various metrics, highlighting significant progress and future plans. Cellectis announced the commencement of three programs under their collaboration with AstraZeneca, including allogeneic CAR T programs for hematological malignancies and solid tumors, and an in vivo gene therapy for a genetic disorder. AstraZeneca's additional equity investment of $140 million resulted in them owning approximately 44% of Cellectis' share capital. Cellectis expects to present Phase 1 data for their UCART22 product in Q3 2025, with regulatory discussions planned to align on a Phase 2 strategy. The NATHALI-01 study for UCART20x22 in non-Hodgkin lymphoma continues, with Phase 1 data expected in late 2025. The company's cash position was strengthened, enabling a cash runway until mid-2027, with cash, cash equivalents, and fixed term deposits totaling $264 million as of December 31, 2024. Cellectis emphasized its focus on advancing clinical trials, leveraging its technology, and expanding strategic partnerships to address unmet medical needs.

Cellectis SA Financial Statement Overview

Summary
Cellectis SA is struggling financially with negative net profit and EBITDA margins, despite some revenue growth. Cash flow improvements are noted, but persistent operating losses and a pressured equity position highlight significant financial challenges.
Income Statement
38
Negative
Cellectis SA's income statement reflects a challenging financial position with a negative net profit margin and declining EBIT. Despite an increase in revenue in the TTM period, the company continues to struggle with profitability, as evidenced by the negative net income and EBITDA margins. Revenue growth shows potential, but persistent operating losses need addressing.
Balance Sheet
45
Neutral
The balance sheet of Cellectis SA displays a relatively stable equity position and an improving debt-to-equity ratio, indicating controlled leverage. However, the company faces a challenge with maintaining a positive equity ratio amidst high liabilities. The decrease in stockholders' equity over the past periods suggests potential financial strain, requiring close monitoring.
Cash Flow
50
Neutral
Cellectis SA shows improvement in cash flow management with a positive operating cash flow in the TTM period. Free cash flow has increased, albeit from a negative base, indicating better cash accrual from operations. However, the free cash flow to net income ratio indicates that net income remains negative, highlighting ongoing profitability challenges.
BreakdownDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue41.51M755.00K19.17M73.95M73.95M
Gross Profit41.51M18.00K17.40M37.67M37.67M
EBITDA-9.46M-92.64M-76.38M-85.44M-43.34M
Net Income-36.76M-101.06M-98.69M-86.28M-72.57M
Balance Sheet
Total Assets383.54M334.27M261.22M382.08M469.47M
Cash, Cash Equivalents and Short-Term Investments260.31M203.81M97.70M186.13M268.24M
Total Debt91.46M85.06M82.85M102.24M111.30M
Total Liabilities252.51M249.57M135.28M145.60M160.63M
Stockholders Equity131.03M84.69M117.97M221.29M275.57M
Cash Flow
Free Cash Flow19.15M-25.82M-89.89M-124.31M-126.52M
Operating Cash Flow22.99M-24.75M-87.44M-104.56M-80.26M
Investing Cash Flow-102.81M-15.51M-2.76M7.28M-54.34M
Financing Cash Flow89.11M82.86M1.15M47.52M27.32M

Cellectis SA Technical Analysis

Technical Analysis Sentiment
Positive
Last Price1.58
Price Trends
50DMA
1.35
Positive
100DMA
1.32
Positive
200DMA
1.51
Positive
Market Momentum
MACD
0.08
Negative
RSI
67.04
Neutral
STOCH
68.74
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For FR:ALCLS, the sentiment is Positive. The current price of 1.58 is above the 20-day moving average (MA) of 1.37, above the 50-day MA of 1.35, and above the 200-day MA of 1.51, indicating a bullish trend. The MACD of 0.08 indicates Negative momentum. The RSI at 67.04 is Neutral, neither overbought nor oversold. The STOCH value of 68.74 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for FR:ALCLS.

Cellectis SA Peers Comparison

Overall Rating
UnderperformOutperform
Sector (55)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
57
Neutral
€215.33M
55
Neutral
€4.62B17.03-50.16%3.66%15.32%-9.52%
51
Neutral
$117.80M-58.55%833.95%38.17%
46
Neutral
€91.08M-49.28%55.02%
FRTNG
44
Neutral
€104.06M-220.48%-97.04%-32.53%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
FR:ALCLS
Cellectis SA
1.58
-0.25
-13.83%
FR:NANO
Nanobiotix
4.60
-0.18
-3.85%
FR:TNG
Transgene
0.78
-0.34
-30.05%
FR:ALSEN
Sensorion SAS
0.33
-0.34
-50.89%

Cellectis SA Corporate Events

Cellectis Reports 2024 Financial Results and Strategic Advances in CAR T-Cell Therapies
Mar 13, 2025

Cellectis has announced its financial results for the fourth quarter and fiscal year 2024, alongside a business update. The company is advancing its clinical trials, particularly UCART22 and UCART20x22, with significant regulatory designations from the FDA and European Commission, enhancing its position in the CAR T-cell therapy market. Its strategic partnership with AstraZeneca, including a $140 million investment, supports the development of next-generation genomic medicines, with a strong cash position projected to last until mid-2027.

Cellectis Advances Clinical Programs and Strengthens AstraZeneca Partnership
Mar 13, 2025

Cellectis has reported its financial results for the fourth quarter and full year 2024, highlighting significant progress in its clinical programs and strategic partnerships. The company is advancing its UCART22 and UCART20x22 programs, with key data readouts expected in 2025. Cellectis has also strengthened its collaboration with AstraZeneca, which includes an additional equity investment of $140 million, ensuring financial stability until mid-2027. The company’s focus remains on developing next-generation genomic medicines to address unmet patient needs.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jul 17, 2025