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Cellectis SA (FR:ALCLS)
:ALCLS

Cellectis SA (ALCLS) AI Stock Analysis

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Cellectis SA

(OTC:ALCLS)

Rating:44Neutral
Price Target:
€1.50
▲(17.19%Upside)
Cellectis SA's stock score is significantly impacted by its financial performance and technical analysis. Persistent net losses and negative profit margins weigh heavily despite recent revenue growth. Technical indicators suggest bearish sentiment, with the stock underperforming across key moving averages. Valuation concerns are exacerbated by a negative P/E ratio and the absence of dividends, further impacting the overall score.

Cellectis SA (ALCLS) vs. iShares MSCI France ETF (EWQ)

Cellectis SA Business Overview & Revenue Model

Company DescriptionCellectis S.A., a clinical stage biotechnological company, develops immuno-oncology products based on gene-edited T-cells that express chimeric antigen receptors to target and eradicate cancer cells. It operates through two segments, Therapeutics and Plants. The company is developing UCART19, an allogeneic T-cell product candidate for the treatment of CD19-expressing hematologic malignancies, such as acute lymphoblastic leukemia; ALLO-501 and ALLO-501A to treat relapsed/refractory diffuse large B-cell lymphoma and follicular lymphoma; ALLO-316 for the treatment of Renal Cell Carcinoma; UCART123 for the treatment of acute myeloid leukemia; and UCART22 to treat B-cell acute lymphoblastic leukemia. It is also developing UCARTCS1 and ALLO-715 for the treatment of multiple myeloma. The company has strategic alliances with Allogene Therapeutics, Inc.; Les Laboratoires Servier; The University of Texas M.D. Anderson Cancer Center; and Iovance Biotherapeutics, as well as a strategic research and development collaboration with Cytovia Therapeutics, Inc. Cellectis S.A. was founded in 1999 and is headquartered in Paris, France.
How the Company Makes MoneyCellectis makes money primarily through the development and commercialization of its gene-editing technologies and therapies. The company generates revenue through strategic partnerships, licensing agreements, and collaborations with other pharmaceutical and biotechnology companies. These partnerships typically involve upfront payments, milestone payments, and royalties on sales of products that utilize Cellectis's technology. Additionally, Cellectis may receive funding from grants and research contracts to support its innovative research and development efforts.

Cellectis SA Earnings Call Summary

Earnings Call Date:May 12, 2025
(Q4-2024)
|
% Change Since: -5.19%|
Next Earnings Date:Jul 31, 2025
Earnings Call Sentiment Positive
The earnings call was largely positive, highlighting strategic collaboration, financial stability, and progress in clinical programs. However, challenges in ongoing arbitration and regulatory uncertainties were noted, but they did not overshadow the advancements and strategic gains made by the company.
Q4-2024 Updates
Positive Updates
Strategic Collaboration with AstraZeneca
Cellectis announced the start of R&D activities for three programs under their collaboration with AstraZeneca, including allogeneic CAR T for hematological malignancies, solid tumors, and an in vivo gene therapy. AstraZeneca completed an additional equity investment of $140 million, owning approximately 44% of Cellectis' share capital.
Financial Strength and Cash Runway
Cellectis' cash, cash equivalents, restricted cash, and fixed term deposits amounted to $264 million as of December 31, 2024, up from $156 million in 2023. The company is confident that their cash runway will fund operations into mid-2027.
UCART22 and UCART20x22 Progress
Cellectis received Orphan Drug Designation and Rare Pediatric Disease designation for UCART22. The company expects to present Phase 1 data for UCART22 in the third quarter of 2025 and for UCART20x22 in late 2025.
Manufacturing and Innovation
Cellectis showcased promising CAR T strategies targeting solid tumors using TALEN gene editing technology, presenting preclinical data at major conferences and publishing articles in scientific journals.
Negative Updates
Challenges in Servier Arbitration
Cellectis is involved in ongoing arbitration with Servier, limiting the company's ability to comment on potential outcomes.
Regulatory and Market Uncertainties
There are ongoing regulatory interactions required to align on Phase 2 registration strategies for UCART22 and UCART20x22, indicating potential uncertainties in development timelines.
Company Guidance
During the Cellectis Full Year 2024 Earnings Conference Call, the company provided guidance on various metrics, highlighting significant progress and future plans. Cellectis announced the commencement of three programs under their collaboration with AstraZeneca, including allogeneic CAR T programs for hematological malignancies and solid tumors, and an in vivo gene therapy for a genetic disorder. AstraZeneca's additional equity investment of $140 million resulted in them owning approximately 44% of Cellectis' share capital. Cellectis expects to present Phase 1 data for their UCART22 product in Q3 2025, with regulatory discussions planned to align on a Phase 2 strategy. The NATHALI-01 study for UCART20x22 in non-Hodgkin lymphoma continues, with Phase 1 data expected in late 2025. The company's cash position was strengthened, enabling a cash runway until mid-2027, with cash, cash equivalents, and fixed term deposits totaling $264 million as of December 31, 2024. Cellectis emphasized its focus on advancing clinical trials, leveraging its technology, and expanding strategic partnerships to address unmet medical needs.

Cellectis SA Financial Statement Overview

Summary
The financial performance of Cellectis SA shows mixed results. The income statement indicates significant revenue growth, but persistent net losses and negative profit margins remain a concern. The balance sheet reflects moderate stability with a manageable debt-to-equity ratio and a strong cash position, but negative net income impacts return on equity. Cash flow improvements are notable; however, the company’s reliance on financing activities to bolster cash reserves is a risk.
Income Statement
40
Negative
The income statement shows significant volatility with a recent revenue surge from $755,000 in 2023 to $41.5 million in 2024, marking a dramatic revenue growth, albeit from a low base. Despite this, the company has consistently posted net losses, with a net profit margin deeply negative at -88.6% in 2024. The EBIT and EBITDA margins are also negative, indicating ongoing operational challenges.
Balance Sheet
55
Neutral
Cellectis SA's balance sheet reflects moderate financial stability with a debt-to-equity ratio of 0.70 in 2024, suggesting manageable leverage. The equity ratio is 34.2%, indicating a reasonable equity base. However, the persistent negative net income impacts return on equity, which remains negative. Overall, the balance sheet is supported by a strong cash position.
Cash Flow
60
Neutral
The cash flow statement highlights an improvement in free cash flow, from a negative point in 2023 to a positive $19.1 million in 2024, showing promising operational cash flow management. The operating cash flow to net income ratio is positive, reflecting efficient cash generation relative to net losses. However, the company relies heavily on financing activities to bolster cash reserves.
Breakdown
Dec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income StatementTotal Revenue
41.51M755.00K19.17M73.95M73.95M
Gross Profit
41.51M18.00K17.40M37.67M37.67M
EBIT
-59.55M-97.30M-89.67M-85.44M-85.44M
EBITDA
-9.46M-92.64M-76.38M-85.44M-43.34M
Net Income Common Stockholders
-36.76M-101.06M-98.69M-86.28M-72.57M
Balance SheetCash, Cash Equivalents and Short-Term Investments
260.31M203.81M97.70M186.13M268.24M
Total Assets
383.54M334.27M261.22M382.08M469.47M
Total Debt
91.46M85.06M82.85M102.24M111.30M
Net Debt
-51.79M-51.65M-14.85M-83.90M-156.94M
Total Liabilities
252.51M249.57M135.28M145.60M160.63M
Stockholders Equity
131.03M84.69M117.97M221.29M275.57M
Cash FlowFree Cash Flow
19.15M-25.82M-89.89M-124.31M-126.52M
Operating Cash Flow
22.99M-24.75M-87.44M-104.56M-80.26M
Investing Cash Flow
-102.81M-15.51M-2.76M7.28M-54.34M
Financing Cash Flow
89.11M82.86M1.15M47.52M27.32M

Cellectis SA Technical Analysis

Technical Analysis Sentiment
Negative
Last Price1.28
Price Trends
50DMA
1.34
Negative
100DMA
1.35
Negative
200DMA
1.57
Negative
Market Momentum
MACD
-0.03
Positive
RSI
35.13
Neutral
STOCH
6.56
Positive
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For FR:ALCLS, the sentiment is Negative. The current price of 1.28 is below the 20-day moving average (MA) of 1.32, below the 50-day MA of 1.34, and below the 200-day MA of 1.57, indicating a bearish trend. The MACD of -0.03 indicates Positive momentum. The RSI at 35.13 is Neutral, neither overbought nor oversold. The STOCH value of 6.56 is Positive, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for FR:ALCLS.

Cellectis SA Peers Comparison

Overall Rating
UnderperformOutperform
Sector (53)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
53
Neutral
$5.22B3.33-44.36%7.55%16.78%-0.12%
44
Neutral
$88.96M-58.55%833.95%38.17%
$175.24M-160.99%
€182.82M
€122.19M-220.48%
DE6OP
€115.53M2.8986.78%
DERFM
€105.51M-49.28%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
FR:ALCLS
Cellectis SA
1.28
-0.47
-27.09%
IPHYF
Innate Pharma SA
1.74
-0.42
-19.44%
GB:0QAV
Nanobiotix
3.87
-0.11
-2.76%
GB:0OCQ
Transgene
0.93
-0.31
-25.00%
DE:6OP
OSE Immunotherapeutics SA
4.99
-1.31
-20.79%
DE:RFM
Sensorion SAS
0.34
-0.30
-46.88%

Cellectis SA Corporate Events

Cellectis Reports 2024 Financial Results and Strategic Advances in CAR T-Cell Therapies
Mar 13, 2025

Cellectis has announced its financial results for the fourth quarter and fiscal year 2024, alongside a business update. The company is advancing its clinical trials, particularly UCART22 and UCART20x22, with significant regulatory designations from the FDA and European Commission, enhancing its position in the CAR T-cell therapy market. Its strategic partnership with AstraZeneca, including a $140 million investment, supports the development of next-generation genomic medicines, with a strong cash position projected to last until mid-2027.

Cellectis Advances Clinical Programs and Strengthens AstraZeneca Partnership
Mar 13, 2025

Cellectis has reported its financial results for the fourth quarter and full year 2024, highlighting significant progress in its clinical programs and strategic partnerships. The company is advancing its UCART22 and UCART20x22 programs, with key data readouts expected in 2025. Cellectis has also strengthened its collaboration with AstraZeneca, which includes an additional equity investment of $140 million, ensuring financial stability until mid-2027. The company’s focus remains on developing next-generation genomic medicines to address unmet patient needs.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.