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FibroGen (FGEN)
NASDAQ:FGEN

FibroGen (FGEN) AI Stock Analysis

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FibroGen

(NASDAQ:FGEN)

42Neutral
FibroGen's overall stock score reflects its financial difficulties, with declining revenues and persistent losses being major concerns. However, strategic actions like selling FibroGen China and focusing on promising pipeline developments provide some optimism for future growth. Bearish technical indicators and unfavorable valuation further weigh down the score.
Positive Factors
Financial Health
The sale of FibroGen China to AstraZeneca is seen as a strategic transaction, enhancing financial resources and allowing focus on U.S. development of key assets.
Pipeline Development
FibroGen remains increasingly focused on progressing its primary therapeutic candidate, FG-3246, with multiple studies providing several opportunities for success.
Strategic Expansion
FibroGen has the option to acquire Fortis Therapeutics, which developed FG-3246, indicating a potential strategic expansion.
Negative Factors
Market Challenges
A combination of the majority of revenue being generated in ex.-U.S. markets, and the asset's previous failure in CKD-anemia in the U.S., is preventing traction with the investors.
Regulatory and Development Risks
Meeting with the FDA to discuss next steps for roxadustat in anemia associated with low-risk myelodysplastic syndrome.

FibroGen (FGEN) vs. S&P 500 (SPY)

FibroGen Business Overview & Revenue Model

Company DescriptionFibroGen, Inc., a biopharmaceutical company, discovers, develops, and commercializes therapeutics to treat serious unmet medical needs. The company is developing Roxadustat, an oral small molecule inhibitor of hypoxia inducible factor prolyl hydroxylases, which has completed Phase III clinical development for the treatment of anemia in chronic kidney disease in the United States, Europe, China, and Japan; and in Phase II/III development in China for anemia associated with myelodysplastic syndromes. It is also developing Pamrevlumab, a human monoclonal antibody that inhibits the activity of connective tissue growth factor that is in Phase III clinical development for the treatment of idiopathic pulmonary fibrosis, pancreatic cancer, liver fibrosis, and diabetic kidney disease, as well as Phase III trial for the treatment of Duchenne muscular dystrophy. The company has collaboration agreements with Astellas Pharma Inc. and AstraZeneca AB. FibroGen, Inc. was incorporated in 1993 and is headquartered in San Francisco, California.
How the Company Makes MoneyFibroGen generates revenue through a combination of product sales, licensing agreements, and collaborative partnerships. The company's primary revenue stream comes from the commercialization of roxadustat, especially in markets like China, where it has partnered with AstraZeneca for distribution. Additionally, FibroGen earns milestone payments and royalties from its partnerships with other pharmaceutical companies involved in the development and commercialization of its products. The company also benefits from research and development collaborations, which provide funding and shared resources to advance its pipeline projects. These partnerships are crucial for FibroGen's earnings as they help offset the high costs associated with drug development and regulatory approvals.

FibroGen Financial Statement Overview

Summary
FibroGen faces significant financial challenges with declining revenues and persistent losses. The negative equity and cash flow issues reflect financial instability and operational inefficiencies, highlighting the need for strategic interventions to improve financial health.
Income Statement
45
Neutral
FibroGen has experienced declining revenue over the past few years, with a significant drop in 2024 compared to previous years. This decline is coupled with persistent negative EBIT and net income, indicating operational challenges and profitability issues. The company also shows negative EBITDA, reflective of its struggles to manage costs effectively amidst falling revenues.
Balance Sheet
30
Negative
The balance sheet reveals high liabilities relative to assets, resulting in negative stockholders' equity, a concerning sign of financial instability. The absence of debt in 2024 is positive, but previous years show reliance on debt, contributing to financial stress. The negative equity ratio further highlights the precarious financial position, indicating significant leverage and risk.
Cash Flow
40
Negative
Operating cash flow has been consistently negative, pointing to challenges in generating cash from core operations. Although free cash flow improved slightly in 2024, it remains negative, indicating cash burn. The cash flow to net income ratios highlight inefficient cash management and an inability to convert revenue into cash profits.
Breakdown
Dec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income StatementTotal Revenue
29.62M147.75M140.73M235.31M176.32M
Gross Profit
14.06M128.90M120.45M222.44M167.45M
EBIT
-150.42M-281.81M-301.02M-288.53M-191.88M
EBITDA
-142.43M-261.40M-282.82M-274.80M-164.28M
Net Income Common Stockholders
-153.10M-284.23M-295.23M-291.03M-189.29M
Balance SheetCash, Cash Equivalents and Short-Term Investments
50.48M235.59M422.01M405.19M686.54M
Total Assets
214.53M423.53M610.09M773.82M826.84M
Total Debt
73.09M170.46M89.89M99.73M37.72M
Net Debt
-50.48M56.77M-65.81M-71.49M-640.67M
Total Liabilities
398.16M585.73M611.57M544.71M385.39M
Stockholders Equity
-183.63M-204.17M-21.45M209.15M422.18M
Cash FlowFree Cash Flow
-138.26M-317.54M-184.67M-112.42M77.61M
Operating Cash Flow
-138.00M-315.02M-145.93M-82.23M81.60M
Investing Cash Flow
125.99M153.66M89.12M-426.97M452.49M
Financing Cash Flow
-255.00K122.75M46.78M-563.00K13.34M

FibroGen Technical Analysis

Technical Analysis Sentiment
Negative
Last Price0.30
Price Trends
50DMA
0.41
Negative
100DMA
0.44
Negative
200DMA
0.48
Negative
Market Momentum
MACD
-0.04
Negative
RSI
43.43
Neutral
STOCH
66.68
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For FGEN, the sentiment is Negative. The current price of 0.3 is below the 20-day moving average (MA) of 0.31, below the 50-day MA of 0.41, and below the 200-day MA of 0.48, indicating a bearish trend. The MACD of -0.04 indicates Negative momentum. The RSI at 43.43 is Neutral, neither overbought nor oversold. The STOCH value of 66.68 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for FGEN.

FibroGen Risk Analysis

FibroGen disclosed 72 risk factors in its most recent earnings report. FibroGen reported the most risks in the “Finance & Corporate” category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

FibroGen Peers Comparison

Overall Rating
UnderperformOutperform
Sector (50)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
79
Outperform
$10.00B20.1623.13%18.49%176.71%
78
Outperform
$62.43B14.9015.95%0.15%8.27%10.35%
78
Outperform
$11.44B27.138.05%17.35%151.40%
75
Outperform
$132.77B278.432.28%2.91%6.16%-91.54%
64
Neutral
$127.47B-3.15%11.64%-114.72%
50
Neutral
$5.51B2.95-43.70%2.78%16.94%3.59%
42
Neutral
$30.26M60.38%5.59%83.59%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
FGEN
FibroGen
0.30
-1.00
-76.92%
BMRN
BioMarin Pharmaceutical
60.02
-30.85
-33.95%
EXEL
Exelixis
36.54
13.72
60.12%
GILD
Gilead Sciences
105.68
40.81
62.91%
REGN
Regeneron
557.91
-335.08
-37.52%
VRTX
Vertex Pharmaceuticals
500.49
106.32
26.97%

FibroGen Earnings Call Summary

Earnings Call Date: Mar 17, 2025 | % Change Since: -31.82% | Next Earnings Date: May 12, 2025
Earnings Call Sentiment Positive
The earnings call presented a positive outlook with significant strategic steps such as the sale of FibroGen China, which strengthens the financial position and supports key pipeline advancements in oncology. However, challenges remain with revenue declines and net losses.
Highlights
Sale of FibroGen China
The sale of FibroGen China to AstraZeneca for approximately $160 million is a transformative transaction that simplifies operations, allows for debt repayment, and extends the cash runway into 2027.
FG-3246 and FG-3180 Advancements
Progress in the development of FG-3246 for metastatic castration-resistant prostate cancer with promising Phase 1 data showing a median radiographic progression-free survival of 8.7 months and an overall response rate of 20%.
Cost Reduction and Financial Improvement
Significant reduction in operating expenses by 51% year-over-year and a decrease in net loss from continuing operations by 53% compared to the previous year, along with a strong cash position.
Roxadustat Opportunity
Potential to develop roxadustat for anemia associated with lower-risk MDS, with a planned FDA meeting to explore this opportunity.
Lowlights
Decrease in Total Revenue
Total revenue for the full year 2024 decreased to $29.6 million from $46.8 million in 2023, a decline attributed to reduced development revenue.
Net Losses
Despite improvements, the company reported a net loss from continuing operations of $153.1 million for full year 2024.
Company Guidance
During the FibroGen Fourth Quarter and Full Year 2024 Earnings Conference Call, guidance was provided on several key metrics and strategic initiatives. FibroGen announced the sale of FibroGen China to AstraZeneca for approximately $160 million, extending their cash runway into 2027 and simplifying operations. The company plans to focus on U.S. pipeline opportunities, particularly FG-3246 and FG-3180, in metastatic castration-resistant prostate cancer (mCRPC). Notably, FG-3246 showed promising results in Phase 1 trials with an 8.7-month median radiographic progression-free survival and a 20% overall response rate. Financially, FibroGen reported a 51% year-over-year decrease in total operating costs and a 43% decrease in SG&A expenses, contributing to a net loss reduction from $323 million in 2023 to $153.1 million in 2024. Looking ahead, the company anticipates $4 million to $8 million in total revenue for 2025 and plans to initiate several clinical trials, including a Phase 2 dose optimization study for FG-3246 by mid-2025.

FibroGen Corporate Events

M&A TransactionsBusiness Operations and Strategy
FibroGen Sells Subsidiary to AstraZeneca for $160M
Positive
Feb 20, 2025

On February 19, 2025, FibroGen entered into a share purchase agreement with AstraZeneca to sell its subsidiary, FibroGen International, for approximately $160 million. The sale includes all rights to Roxadustat in China, with the transaction expected to close by mid-2025, subject to regulatory approval. This move significantly strengthens FibroGen’s financial position, extending its cash runway into 2027 and allowing it to focus on advancing its oncology pipeline. The company plans to repay its term loan to Morgan Stanley Tactical Value upon closing, simplifying its capital structure.

Glossary
OutperformA stock rated as "Outperform" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock is likely to deliver higher returns compared to the average returns of other stocks in the same sector or market index. Investors might consider this stock a good buying opportunity.
NeutralA stock rated as "Neutral" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly attractive nor unattractive for investment. Investors may consider holding onto the stock, as it is not expected to either significantly outperform or underperform the market.
UnderperformA stock rated as "Underperform" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests that the stock may deliver lower returns compared to the average returns of other stocks in the same sector or market index. Investors might consider selling the stock or avoiding it as an investment.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.