Strong Q4 and Full-Year Organic Revenue Growth
Q4 2025 organic constant currency revenue growth of 9%; full-year 2025 organic constant currency revenue growth of 7%; reported Q4 revenue $1,140M (+12% YoY) and full-year reported revenue $4,715M (+6% YoY).
Innovation Revenue Outperformed and 2026 Raise
2025 innovation revenue of $892M (largest quarter for innovation in Q4); company raised 2026 innovation outlook to $1,150M (commitment to at least +$250M growth versus 2025).
Broad Product Momentum — Credelio Quattro
Credelio Quattro described as fastest blockbuster in company history; major U.S. broad‑spectrum endectocide market grew ~30% YoY and Quattro is gaining clinic share (≈1/3 of clinics penetrated) with strong Puppy Index performance and meaningful portfolio uplifts to other products.
Broad Product Momentum — ZENRELIA
ZENRELIA delivered double‑digit JAK market share in several international markets (e.g., Brazil ~40%, Japan >30%), ~50% clinic penetration in the U.S., >80% reorder rate, and notable early traction in Europe, UK, and Australia.
Other High-Impact Launches and Growth
Bifrenna received USDA approval (Dec 31) and is planned for phased 2026 launch; OTC AdTab sales up >50%, becoming #1 oral OTC in Europe; Experior up 35% in Q4 and crossed $200M in 2025 (nearly +80% YoY for the year).
Strong Farm and Pet Health Performance
Q4 US farm animal +17% and US pet health +10% (Q4); international pet health +8% and international farm animal +4% on organic constant currency basis.
Financial Execution — EBITDA, EPS, and Deleveraging
Q4 adjusted EBITDA $189M (+7% YoY); full-year adjusted EBITDA $901M; full-year adjusted EPS $0.94 vs $0.91 in 2024. Net leverage improved to 3.6x at year-end with target 3.1–3.3x for 2026 and path to <3x in 2027.
2026 Guidance in Line with Long-Term Algorithm
2026 guidance: organic constant currency revenue growth 4–6% (revenue $4,950–$5,020M), adjusted EBITDA $955–$985M (~+8% at midpoint), adjusted EPS $1.00–$1.06 (~+10% at midpoint), and gross margin expansion expected ~+40 bps.
Operational Productivity Initiatives
Elanco Ascend productivity program underway; restructuring expected to generate ~$25M in savings in 2026 and support margin expansion while funding launches and R&D.
Strategic M&A and Pipeline
Signed agreement to acquire AHV International (dutch farm-animal innovator) to expand dairy portfolio; R&D engine targeting five-to-six potential blockbuster approvals through 2031 and Big Six expected to double from 2025 to 2028.