Strong Top-Line and Q4 Performance
Net sales of EUR 43.6 billion for full year 2025, up 9.9% at constant exchange rates; Q4 sales EUR 11.3 billion, up 13.3% year-over-year.
High EPS and Margin Expansion
Business EPS grew robustly (Q4 business EPS growth cited at 26.7%); full year business EPS excluding buybacks +12.2% and including share buybacks +15%. Business gross margin expanded by 1.8 percentage points to 77.5%; business operating income increased 11.9% with BOI margin of 27.8%.
Strong Cash Generation and Balance Sheet
Free cash flow of EUR 8.1 billion (18.5% of sales) in 2025 with target to sustainably reach at least 20% of net sales in the medium term. Net debt ~EUR 11 billion with a conservative 0.8x net debt-to-EBITDA and AA rating maintained.
Successful New Product Launches and Commercial Momentum
New launches reached EUR 5.7 billion in sales; newly launched medicines and vaccines grew 34% in 2025. ALTUVIIIO achieved blockbuster status with EUR 1.2 billion full year sales. Beyfortus delivered EUR 1.8 billion (up 9.5%) and Dupixent reached EUR 15.7 billion annual sales (quarterly EUR 4.2 billion), with >30% patient growth year-over-year across indications.
Pipeline and Regulatory Delivery
2025 milestones included 12 Phase III readouts, 15 Phase II readouts, 10 new molecules added to Phase I (including 3 gene therapies), 20 regulatory approvals and 22 acceptances. Three new medicines/vaccines approved in 2025: Qfitlia (hemophilia RNAi), Wayrilz (BTK inhibitor for ITP), and Nuvaxovid (recombinant COVID-19 vaccine).
Notable Phase III Wins and Development Programs
Positive Phase III results across most of the amlitelimab atopic dermatitis program and Dupixent met primary endpoint in AFRS; SARCLISA subcutaneous formulation success; multiple late-stage readouts expected in 2026–2027 (amlitelimab remaining trials, lunsekimig, venglustat).
Strategic M&A and Capital Allocation
Completed Opella transaction and deployed EUR 10.4 billion into business development and M&A (including Blueprint, Vicebio, Dren Bio DR-0201, Vigil). Completed EUR 5 billion share buyback program and proposed/announced further BD (proposed Dynavax acquisition for HEPLISAV‑B and shingles candidate); dividend increased +5% to EUR 4.12 (31st consecutive year).
Operational and Sustainability Initiatives
Inventory optimized (reduced by nearly 30 days), OpEx as % of sales reduced to 39.9%, continued investment in U.S. manufacturing capacity, and co-developed PAS 2090 (global standard for measuring/reducing environmental impact of medicines and vaccines).