Top-line growth and profit performance (2025)
Sales grew 10% in 2025 and operating profit increased ~6% at constant exchange rates (reported operating profit was down 1% in DKK but +6% CER excluding currency effects). Net profit was DKK 102 billion and cash from operations was close to DKK 120 billion.
Obesity franchise expansion and Wegovy momentum
Obesity care sales increased 31% in 2025. Wegovy sales reached DKK 28 billion in 2025 (up 134% year-over-year). The Wegovy pill received FDA approval (Dec 22) and launched in the U.S. on Jan 5, with early uptake: ~50,000 prescriptions in the week ending Jan 23 (≈45,000 self-pay) and management reported >170,000 people on the Wegovy pill by a later weekly update. Combined injectable + pill Wegovy NBRx exceed ~75,000 weekly; Wegovy injectable holiday week TRx ~230,000.
GLP-1 market leadership and international growth
The global GLP-1 market grew >30% in 2025. Novo Nordisk total sales: U.S. +8%, International Operations +14%. GLP-1 volume growth in International Operations was 44%, with Novo Nordisk holding ~62% volume market share in GLP-1s in IO.
Strong commercial traction in self-pay and direct channels
Self-pay and direct channels expanded rapidly: self-pay represents ~30% of injectable Wegovy prescriptions; NovoCare Pharmacy launched March 2025; combined self-pay TRx reached close to 120,000 current weekly TRxs across Wegovy and Ozempic. Early Wegovy pill access coverage includes CVS, Prime, Optum and Anthem.
R&D and pipeline progress – CagriSema (REIMAGINE 2) and zenagamtide
REIMAGINE 2: CagriSema 2.4 mg demonstrated superior A1c reduction vs semaglutide 2.4 mg (1.91 vs 1.76 percentage points from baseline ~8.2%) and superior weight loss (14.2% mean). >40% of treated participants achieved >15% weight loss; ~25% achieved >20%. Zenagamtide (Phase II): once-weekly A1c reductions up to 1.8 percentage points (baseline 7.8%); oral zenagamtide A1c reductions up to 1.5 percentage points, with high proportions achieving HbA1c <7% (up to 89.1% weekly; ~78% oral).
Pipeline breadth and upcoming catalysts
Multiple upcoming readouts and regulatory milestones: REIMAGINE 1 readout expected Q1 2026; REDEFINE 4 (weight loss vs tirzepatide) result expected Q1 2026; etavopivat HIBISCUS Phase III readout for sickle cell expected Q2 2026; regulatory decisions for denecimig and other semaglutide filings anticipated in H2 2026; AMBITION and AMAZE Phase III programs planned for zenagamtide in 2026.
Capital allocation and shareholder returns
Deployment of capital in 2025 included ~DKK 60 billion to manufacturing expansion and ~DKK 30 billion to R&D/business development. Returned ~DKK 52 billion to shareholders in 2025; final dividend proposal brings total 2025 dividend to DKK 11.70 (a 2.6% increase). New share repurchase program up to DKK 15 billion announced.
Balance sheet and cashflow visibility
Management provided updated definitions and guidance: free cash flow expected DKK 35–45 billion for 2026; capital expenditure guidance ~DKK 55 billion for 2026 with expected decline in subsequent years as projects finalize.
Manufacturing / supply confidence
Management reaffirmed confidence in Wegovy pill supply for the U.S. market despite strong early demand and noted API facilities and capacity expansions are on track with major API facilities expected online during the year.