Solid Q4 Revenue Growth
Total company revenues of $16.4 billion, up 5% year-over-year (4% ex-FX) for the quarter; non-GAAP EPS of $2.04; gross margin at 79.7% (see margin drivers below).
KEYTRUDA Continued Strength
KEYTRUDA family sales of $8.4 billion, up 5% year-over-year driven by uptake in earlier-stage cancers and metastatic indications; US timing headwind of ~ $200 million noted; KEYTRUDA QLEX initial sales of $35 million with a permanent J-code expected in April and management targeting 30%–40% IV-to-QLEX adoption by 2028.
Material Pipeline and Long-Term Commercial Opportunity
Management cites line of sight to over $70 billion of potential commercial opportunity by the mid-2030s (up ~$20 billion YoY), more than double consensus 2028 KEYTRUDA peak; 21 potential new growth drivers identified with 10 expected to be substantially clinically de-risked over the next two years; 18 positive Phase III readouts and initiation of 21 Phase III trials in 2025.
Strategic Acquisitions and New Assets
Completed acquisitions of Sidera Therapeutics and Verona Pharma to expand respiratory and infectious disease portfolios; Sidera asset MK1406 (long-acting antiviral for influenza prevention) described as potentially first-in-class with >$5 billion revenue potential.
Strong Growth in Select Products
Wellyrec sales up 37% to $220 million (primarily U.S. advanced renal cell carcinoma uptake); WinRevair global sales $467 million with >1,500 U.S. new patients and >27,000 prescriptions dispensed; Cefaxib pneumococcal launch sales of $279 million; O2Ver (post-Verona) sales of $178 million with strong new patient starts and increased prescribing physicians.
Animal Health Momentum
Animal health sales increased 6% overall with livestock up 9%; companion animal sales were flat but supported by new launches (offset by reduced vet visits).
Clinical and Regulatory Milestones
Notable late-stage and regulatory progress: enlicitide Phase III results (oral PCSK9) with publications/acceptances (JAMA/NEJM); positive CADANCE Phase II for winravir supporting new indications; positive topline for islotrovir (HIV) and multiple Keytruda approvals/label expansions (including bladder cancer regimens and Keytruda SC approval in EU); several near-term PDUFA/readouts called out (HIV, oncology, cardiometabolic, ophthalmology).
2026 Revenue Guidance and Underlying Growth Drivers
2026 non-GAAP revenue guidance of $65.5–$67.0 billion (growth of 1%–3%, including ~1ppt positive FX); management expects growth driven by new launches, continued oncology strength, and animal health despite identified headwinds.