Persistent Revenue DeclineMulti-year top-line shrinkage undermines scale and operating leverage, making it harder to absorb fixed R&D and G&A costs. Over months this reduces bargaining power with partners, limits demonstrated commercial traction, and raises the hurdle for returning to sustainable, self-funded growth.
Chronic Cash BurnSustained negative operating and free cash flow force reliance on external financing or milestone receipts, increasing dilution or covenant risk. Over a 2–6 month horizon this constrains discretionary R&D, heightens execution risk for clinical programs, and pressures management to secure deals or capital.
Eroding Equity And Negative ReturnsDeclining equity and a ~-30% ROE reflect cumulative losses that weaken the capital base. Persisting over months, this erodes stakeholder confidence, reduces shock absorption for adverse outcomes, and can raise cost of capital or complicate partnership negotiations as counterparties discount solvency risk.