Financial RunwayAvailable cash appears limited relative to current spending, creating a need for additional financing that could dilute existing shareholders.
Safety And Dose InterruptionsHigher-than-expected drug exposures led to dose adjustments and a pause in a higher-dose cohort, highlighting unresolved safety and tolerability risks for the programs.
Target-related Off-tumor ToxicityExpression of the Nectin-4 target in healthy tissues has been linked to skin-related toxicities with similar therapies, raising target-specific safety concerns for comparable approaches.