Dose Optimization UncertaintyThe maximum tolerated dose has not been established, creating uncertainty around the optimal therapeutic dose and dosing strategy for achieving durable benefit.
Financial Runway And Dilution RiskAvailable cash relative to current spending suggests limited runway and raises the prospect of additional financing that could dilute shareholders.
Safety And Tolerability ConcernsHigher-than-anticipated drug exposures prompted dose adjustments and a pause in a higher-dose cohort, highlighting ongoing safety and tolerability risks for lead programs.