Market ReactionThe market’s muted reaction to the COMP005 trial results—CMPS is down 20% since the data release—misrepresents the trial’s success, which provides a validated safety baseline and a credible efficacy signal.
Stock PerformanceCMPS shares sank ~45% on the news and have barely recovered.
Trial ConcernsConcerns were raised after the negative Lykos AdComm and CRL about functional unblinding, expectation bias, selection bias, missing data, and potential trial personnel misconduct.