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Coherus Biosciences (CHRS)
NASDAQ:CHRS

Coherus Biosciences (CHRS) AI Stock Analysis

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CHRS

Coherus Biosciences

(NASDAQ:CHRS)

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Neutral 47 (OpenAI - 4o)
Rating:47Neutral
Price Target:
$1.00
▼(-26.47% Downside)
Coherus Biosciences' overall stock score reflects significant financial challenges and valuation concerns, despite positive strategic initiatives highlighted in the earnings call. Technical indicators suggest bearish momentum, and the lack of dividend yield further impacts the valuation score.
Positive Factors
Pipeline Progress
The advancement of clinical trials and pursuit of multiple cancer indications demonstrate Coherus' scientific leadership and potential for future growth.
Strategic Focus
The divestiture of non-core biosimilar businesses allows Coherus to concentrate resources on its oncology pipeline, enhancing long-term strategic focus.
Financial Management
The reduction in operating expenses through streamlined operations reflects effective financial management, improving profitability prospects.
Negative Factors
Revenue Decline
The substantial decline in revenue growth indicates challenges in maintaining market share and competitive positioning, affecting long-term sustainability.
Cash Flow Issues
Persistent negative cash flows highlight liquidity concerns, potentially limiting the company's ability to invest in growth and manage debt effectively.
Community Engagement Challenges
Limited awareness among community physicians restricts market penetration, posing a challenge to expanding the customer base and achieving sales targets.

Coherus Biosciences (CHRS) vs. SPDR S&P 500 ETF (SPY)

Coherus Biosciences Business Overview & Revenue Model

Company DescriptionCoherus Oncology, Inc., a biopharmaceutical company, researches, develops, and commercializes immunotherapies to treat cancer in the United States. The company develops UDENYCA, a biosimilar to Neulasta, a long-acting granulocyte-colony stimulating factor; LOQTORZI, a novel next-generation programmed death receptor-1 inhibitor; and Casdozokitug, an investigational recombinant human immunoglobulin isotype (IgG1) monoclonal antibody targeting interleukin 27. It also develops CHS-114, an investigational highly specific human afucosylated IgG1 monoclonal antibody, a chemokine receptor highly expressed on Treg cells in the tumor microenvironment (TME); and CHS-1000, Anti-ILT4 monoclonal antibody for solid tumors. In addition, the company offers GSK4381562, an antibody targeting CD112R to treat tumor cells; YUSIMRY, a biosimilar to Humira for inflammatory diseases characterized by increased production of tumor necrosis factor (TNF) in the body, such as rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, psoriasis, and ulcerative colitis; and CIMERLI, a Lucentis biosimilar to treat neovascular age-related macular degeneration, macular edema following retinal vein occlusion, diabetic macular edema, diabetic retinopathy, and myopic choroidal neovascularization. It has a collaboration agreement with Junshi Biosciences for the co-development and commercialization of toripalimab; agreement with Surface and Adimab LLC; license agreements with Bioeq AG and Genentech, Inc. and Surface and Vaccinex, Inc.; and out-licensing agreement with Novartis Institutes for Biomedical Research, Inc. and GlaxoSmithKline Intellectual Property No. 4 Limited. The company was formerly known as Coherus BioSciences, Inc. and changed its name to Coherus Oncology, Inc. in May 2025. The company was incorporated in 2010 and is based in Redwood City, California.
How the Company Makes MoneyCoherus Biosciences generates revenue primarily through the sales of its biosimilar products, which are designed to compete with existing biologic therapies in the market. The company's key revenue streams include the commercialization of its approved biosimilars, which are sold directly to healthcare providers and pharmacies. Additionally, Coherus may engage in partnerships or licensing agreements with other biopharmaceutical companies, which can provide upfront payments, milestone payments, and royalties based on product sales. These strategic partnerships are crucial for expanding its product portfolio and accelerating market access. Furthermore, Coherus may benefit from cost savings associated with the development of biosimilars compared to original biologics, allowing for competitive pricing and improved profit margins.

Coherus Biosciences Earnings Call Summary

Earnings Call Date:Nov 06, 2025
(Q3-2025)
|
% Change Since: |
Next Earnings Date:Mar 17, 2026
Earnings Call Sentiment Positive
The earnings call reflects a generally positive outlook, with strong financial performance, strategic focus on pipeline development, and effective market expansion strategies. However, some challenges remain in regional sales discrepancies and community physician engagement.
Q3-2025 Updates
Positive Updates
Strong Financial Performance
LOQTORZI net revenue grew to $11.2 million, a 12% increase quarter-over-quarter and 92% increase year-over-year. The company has significantly improved its balance sheet with $192 million in cash and investments and a 69% decrease in non-TSA liabilities.
Pipeline Progress and Strategic Focus
Coherus Oncology is advancing its clinical trials, particularly with LOQTORZI in combination with proprietary assets like CHS-114 and casdozokitug. Enrollment is on track, and the company is pursuing multiple cancer indications, demonstrating its scientific leadership.
Market Expansion and Sales Strategy
The company is expanding its sales force by 15% and implementing a remote sales team to increase reach, particularly in the community setting where awareness of LOQTORZI's clinical benefits needs reinforcement.
Reduction in Operating Expenses
SG&A expenses decreased by 11% compared to last year due to decreased headcount, reflecting the company's focus on spending discipline and operational streamlining.
Negative Updates
Regional Sales Discrepancies
One region showed flat demand for LOQTORZI due to post-restructure vacancies, impacting the overall national average growth despite other regions performing well.
Challenges in Community Physician Engagement
There is low awareness of LOQTORZI's preferred position in NCCN guidelines among community physicians, which affects its market penetration outside of hospital-based specialists.
Company Guidance
In the Coherus Oncology Q3 2025 Earnings Conference Call, the company provided guidance reflecting strong execution across financial, operational, and strategic dimensions. They reported a significant 12% quarter-over-quarter increase in LOQTORZI sales, reaching $11.2 million, with expectations to achieve $150-$200 million in peak sales by mid-2028. Coherus has streamlined operations, reducing SG&A expenses by 11% year-over-year, and forecasting annual SG&A costs of $90-$100 million for 2025. They have bolstered their balance sheet, maintaining $192 million in cash and investments, and paying down near-term debt. The company is advancing its clinical programs with CHS-114 and casdozokitug, aiming for multiple data readouts in 2026, while exploring global partnering opportunities to support development costs. Coherus also announced strategic initiatives to expand its commercial reach, including sales force expansion and enhanced multichannel educational efforts to drive growth in the community segment.

Coherus Biosciences Financial Statement Overview

Summary
Coherus Biosciences is facing financial challenges with declining revenues and profitability pressures. The balance sheet shows some improvement, but historical leverage issues persist. Cash flow metrics highlight ongoing liquidity concerns.
Income Statement
45
Neutral
Coherus Biosciences has experienced significant revenue declines in the TTM period, with a negative revenue growth rate of -41.47%. The gross profit margin has decreased from previous years, indicating pressure on profitability. Despite a positive net profit margin in the TTM period, historical data shows consistent net losses, highlighting volatility in earnings. The negative EBIT and EBITDA margins further underscore operational challenges.
Balance Sheet
40
Negative
The company's balance sheet shows improvement in the TTM period with a positive stockholders' equity, reducing the debt-to-equity ratio significantly. However, historical data reveals high leverage and negative equity in prior years, indicating financial instability. The return on equity remains negative, reflecting ongoing profitability challenges.
Cash Flow
35
Negative
Coherus Biosciences has faced consistent negative operating and free cash flows, with a declining trend in free cash flow growth. The operating cash flow to net income ratio is negative, indicating cash flow issues relative to earnings. Despite a positive free cash flow to net income ratio, the overall cash flow position remains weak.
BreakdownTTMDec 2024Dec 2023Dec 2022Dec 2021Dec 2020
Income Statement
Total Revenue83.57M266.96M257.24M211.04M326.55M475.82M
Gross Profit39.94M149.41M98.25M140.96M268.96M438.16M
EBITDA-171.31M60.94M-193.94M-255.58M-260.69M161.84M
Net Income154.97M28.51M-237.89M-291.75M-287.10M132.24M
Balance Sheet
Total Assets516.52M448.53M629.60M480.85M679.33M841.65M
Cash, Cash Equivalents and Short-Term Investments191.66M125.99M117.75M191.68M417.19M541.16M
Total Debt40.69M269.90M480.84M480.42M419.02M417.10M
Total Liabilities428.75M580.52M823.03M618.26M581.61M560.67M
Stockholders Equity87.77M-131.99M-193.43M-137.42M97.73M280.97M
Cash Flow
Free Cash Flow-90.19M-20.44M-175.17M-243.16M-38.72M146.91M
Operating Cash Flow-90.19M-20.44M-174.88M-241.12M-37.43M154.15M
Investing Cash Flow377.38M230.32M144.64M-166.85M-138.41M-14.40M
Financing Cash Flow-281.56M-186.97M69.60M54.33M51.88M223.95M

Coherus Biosciences Technical Analysis

Technical Analysis Sentiment
Positive
Last Price1.36
Price Trends
50DMA
1.44
Negative
100DMA
1.36
Positive
200DMA
1.12
Positive
Market Momentum
MACD
>-0.01
Negative
RSI
51.60
Neutral
STOCH
58.20
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For CHRS, the sentiment is Positive. The current price of 1.36 is above the 20-day moving average (MA) of 1.30, below the 50-day MA of 1.44, and above the 200-day MA of 1.12, indicating a neutral trend. The MACD of >-0.01 indicates Negative momentum. The RSI at 51.60 is Neutral, neither overbought nor oversold. The STOCH value of 58.20 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for CHRS.

Coherus Biosciences Risk Analysis

Coherus Biosciences disclosed 68 risk factors in its most recent earnings report. Coherus Biosciences reported the most risks in the "Tech & Innovation" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Coherus Biosciences Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
60
Neutral
$219.11M-51.06%-44.94%-274.42%
55
Neutral
$139.13M24.8912.64%35.42%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
49
Neutral
$165.69M-2.93-271.32%-75.77%-31.24%
47
Neutral
$164.38M-0.86-72.54%-19972.15%
43
Neutral
$336.16M-8.23-84.33%59.04%
42
Neutral
$135.52M24.6715.95%448.44%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
CHRS
Coherus Biosciences
1.36
-0.07
-4.90%
SLS
SELLAS Life Sciences Group
2.36
1.45
159.34%
PLX
Protalix
1.73
0.00
0.00%
MCRB
Seres Therapeutics
14.98
-4.32
-22.38%
GNFT
Genfit SA
5.82
2.00
52.36%
IPHA
Innate Pharma
1.75
-0.35
-16.67%

Coherus Biosciences Corporate Events

M&A TransactionsBusiness Operations and Strategy
Coherus Biosciences Divests UDENYCA Business
Neutral
Nov 13, 2025

On April 11, 2025, Coherus Biosciences sold its UDENYCA business, marking a significant divestiture of its biosimilar businesses, which included the UDENYCA, YUSIMRY, and CIMERLI franchises. This strategic shift led to the reclassification of these businesses as discontinued operations in their financial reports, reflecting a focus on their innovative oncology pipeline and the expansion of LOQTORZI sales.

Delistings and Listing ChangesRegulatory Filings and Compliance
Coherus Biosciences Regains Nasdaq Compliance
Positive
Sep 8, 2025

On June 30, 2025, Coherus Oncology, Inc. received a deficiency notice from Nasdaq due to its stock price falling below $1.00 per share for 30 consecutive business days. By September 5, 2025, the company regained compliance with Nasdaq’s listing requirements, ensuring its continued presence on the Nasdaq Global Market.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 07, 2025