Progress in CAB Platform Clinical Programs
BioAtla's conditionally active biologic (CAB) platform clinical programs are advancing well, with promising results in several areas. The EpCAM and CAB CD3 bispecific T-cell engager antibody is progressing in dose escalation without reaching the maximally tolerated dose, and multiple patients are experiencing tumor reduction. The CAB-AXL-ADC Mec-V program shows ongoing antitumor activity with confirmed responses among patients with MKRAS mutations, with notable overall survival rates that exceed standard care.
Positive Developments in Phase 2 Clinical Programs
The CAB R2-ADC Oz-V program is demonstrating new responses in treatment-refractory head and neck cancer, with a 100% disease control rate in HPV-positive patients. The CAB-CTLA-4 antibody, Evalstotug, shows a 64% overall response rate and a 100% disease control rate in unresectable/metastatic melanoma, with a favorable safety profile compared to ipilimumab.
Financial Improvements
R&D expenses decreased from $22.7 million in Q4 2023 to $11.6 million in Q4 2024 due to program prioritization, and general and administrative expenses also decreased by $1.3 million. The net loss for Q4 2024 was reduced to $14.9 million from $26.9 million in the previous year.
Corporate Strategy and Future Outlook
BioAtla is extending its runway beyond key clinical readouts in the first half of 2026 by streamlining resources, including a workforce reduction of over 30%. The company is advancing discussions with potential collaborators for its Phase 2 assets, with expectations for significant partnerships.