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Cynata Therapeutics Limited (AU:CYP)
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Cynata Therapeutics Limited (CYP) AI Stock Analysis

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AU:CYP

Cynata Therapeutics Limited

(OTC:CYP)

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Neutral 52 (OpenAI - 5.2)
Rating:52Neutral
Price Target:
AU$0.37
▲(27.24% Upside)
The score is held back primarily by weak financial performance (persistent losses and ongoing cash burn despite some stabilization), partially offset by strong technical momentum. Valuation also remains a concern due to negative earnings and no dividend support.
Positive Factors
Debt-free balance sheet
Zero debt materially lowers financial risk for a clinical-stage biotech, reducing interest burden and covenant constraints. This preserves optionality to fund multi-year trials or pursue partnerships without servicing debt, improving resilience during lengthy development timelines.
Proprietary Cymerus platform
Owning an iPSC-derived allogeneic MSC platform provides a structural competitive advantage: scalable, off-the-shelf manufacturing, greater batch consistency and IP differentiation. This enhances licensing appeal and supports durable commercial potential if clinical efficacy is confirmed.
High gross margins on reported revenue
Near-100% gross margins imply low incremental production costs for product units, suggesting attractive unit economics once fixed R&D and SG&A are absorbed. This supports long-term profitability potential for licensing or direct commercialization if revenue scales.
Negative Factors
Persistent negative cash flow
Sustained negative operating and free cash flow forces reliance on external funding, increasing dilution and financing risk over multi-year clinical programs. Even with some improvement, ongoing cash burn constrains runway and strategic flexibility absent major partnerships or capital raises.
Erosion of shareholder capital
Material declines in equity and assets reflect cumulative losses that weaken the company’s capital base. This reduces financial headroom for trials or manufacturing scale-up, can hamper deal leverage with partners, and heightens vulnerability to adverse clinical or regulatory outcomes.
Large operating losses and negative margins
Very large operating losses and extreme negative margins indicate profitability is distant. This structural loss profile increases dependence on milestone payments or financings, risks repeated dilution, and means commercial viability hinges on successful late-stage results or transformative partnerships.

Cynata Therapeutics Limited (CYP) vs. iShares MSCI Australia ETF (EWA)

Cynata Therapeutics Limited Business Overview & Revenue Model

Company DescriptionCynata Therapeutics Limited (CYP) is an Australian biotechnology company focused on the development and commercialization of innovative stem cell therapies. The company specializes in Cymerus™, a proprietary technology for manufacturing mesenchymal stem cells (MSCs) at scale. This platform enables the production of therapeutic stem cells without the limitation of donor availability, supporting the treatment of various diseases and medical conditions. Cynata's core products target applications in regenerative medicine, encompassing indications such as cardiovascular disease, respiratory ailments, and graft-versus-host disease (GvHD).
How the Company Makes MoneyCynata Therapeutics Limited primarily generates revenue through strategic partnerships, licensing agreements, and milestone payments associated with their proprietary Cymerus™ technology. The company collaborates with pharmaceutical and biotechnology firms that seek to integrate Cynata's MSCs into their therapeutic pipelines. These partnerships often involve upfront licensing fees, ongoing research and development funding, and potential royalty payments upon successful commercialization of new therapies. Additionally, Cynata seeks to secure government and private grants to support its research initiatives. The company's earnings are significantly influenced by the progress and success of its clinical trials and the subsequent adoption of its stem cell products in the healthcare market.

Cynata Therapeutics Limited Financial Statement Overview

Summary
Cynata Therapeutics Limited faces significant financial challenges, with persistent losses impacting profitability and cash flow. While the company benefits from a debt-free balance sheet and strong liquidity, the high cash burn rate and negative profit margins are concerning. Improvements in revenue generation and cost control are essential to achieve financial stability.
Income Statement
Cynata Therapeutics Limited has shown a fluctuating revenue trend, with a recent increase to $2.32 million from $1.65 million last year, suggesting some positive momentum. However, the company remains unprofitable with a negative net income of $9.74 million, leading to a negative net profit margin. The EBIT and EBITDA margins are also negative, highlighting challenges in cost management and operational efficiency.
Balance Sheet
The company maintains a solid equity position with no debt, resulting in a debt-to-equity ratio of zero. However, the return on equity is negative due to persistent losses, indicating inefficiencies in utilizing shareholder funds. With a significant portion of assets in cash or equivalents, liquidity is strong, but the high cash burn rate could pose a risk if losses continue.
Cash Flow
Cynata Therapeutics' cash flow situation is challenging, with a negative operating cash flow of $9.96 million and negative free cash flow. This indicates heavy cash consumption, which is unsustainable in the long term without revenue growth or additional financing. The free cash flow to net income ratio is unfavorable, reflecting inefficiencies in cash management.
BreakdownTTMDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue1.89M1.89M2.32M1.65M7.77M1.55M
Gross Profit1.89M1.89M2.32M1.37M7.49M1.27M
EBITDA-9.33M-9.33M-9.95M-15.65M-6.00M-8.80M
Net Income-9.39M-9.39M-9.74M-14.28M-5.45M-7.69M
Balance Sheet
Total Assets7.20M7.20M8.39M18.99M26.55M29.97M
Cash, Cash Equivalents and Short-Term Investments5.05M5.05M6.21M16.17M23.80M26.72M
Total Debt0.000.000.000.000.000.00
Total Liabilities1.22M1.22M1.17M2.26M2.59M1.60M
Stockholders Equity5.98M5.98M7.22M16.73M23.96M28.37M
Cash Flow
Free Cash Flow-8.72M-8.77M-9.96M-14.28M-3.30M-5.16M
Operating Cash Flow-8.72M-8.72M-9.96M-14.28M-3.30M-5.16M
Investing Cash Flow-50.00K-50.00K0.000.000.000.00
Financing Cash Flow7.61M7.61M0.006.72M210.12K18.20M

Cynata Therapeutics Limited Technical Analysis

Technical Analysis Sentiment
Positive
Last Price0.29
Price Trends
50DMA
0.28
Positive
100DMA
0.25
Positive
200DMA
0.21
Positive
Market Momentum
MACD
0.03
Negative
RSI
66.79
Neutral
STOCH
58.53
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For AU:CYP, the sentiment is Positive. The current price of 0.29 is below the 20-day moving average (MA) of 0.31, above the 50-day MA of 0.28, and above the 200-day MA of 0.21, indicating a bullish trend. The MACD of 0.03 indicates Negative momentum. The RSI at 66.79 is Neutral, neither overbought nor oversold. The STOCH value of 58.53 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Positive sentiment for AU:CYP.

Cynata Therapeutics Limited Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
52
Neutral
AU$92.61M-8.63-138.54%16.61%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
51
Neutral
AU$159.57M-15.83-41.51%-40.74%-21.21%
50
Neutral
AU$91.48M-9.56-49.72%10.78%
46
Neutral
AU$26.59M-5.45-157.93%-36.89%
44
Neutral
AU$33.06M-9.09-143.71%306.88%
38
Underperform
AU$51.82M-7.60-159.86%110.44%35.90%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
AU:CYP
Cynata Therapeutics Limited
0.39
0.17
73.33%
AU:PTX
Prescient Therapeutics Limited
0.09
0.04
93.33%
AU:SPL
Starpharma Holdings Limited
0.38
0.28
261.90%
AU:ADO
AnteoTech Ltd
0.02
0.00
0.00%
AU:NOX
Noxopharm Ltd.
0.09
<0.01
10.98%
AU:AVE
Avecho Biotechnology Limited
0.01
0.00
0.00%

Cynata Therapeutics Limited Corporate Events

Cynata Completes Enrollment in Phase 2 aGvHD Trial
Dec 14, 2025

Cynata Therapeutics has completed patient enrollment in its Phase 2 clinical trial of CYP-001 for treating acute graft versus host disease (aGvHD), a serious complication of bone marrow transplantation. The trial enrolled 65 participants across the US, Europe, and Australia, and aims to address the unmet need for effective aGvHD treatments, as current steroid treatments often fail. The primary evaluation period will conclude in March 2026, with results expected by June 2026. CYP-001 has shown promise in previous trials, with high response rates and no serious safety concerns, positioning Cynata as a potential leader in aGvHD treatment.

Cynata’s CYP-001 Therapy Shows Promise in Kidney Transplant Trial
Dec 3, 2025

Cynata Therapeutics announced a positive review by an independent Data and Safety Monitoring Board (DSMB) for the first cohort in their Phase 1/2 kidney transplant trial using CYP-001, a Cymerus™ MSC therapy. The trial, managed by Leiden University Medical Centre, aims to establish CYP-001 as a safer alternative to current anti-rejection drugs, which have significant toxicity. The DSMB found no safety concerns, allowing the trial to proceed to the next cohort, potentially positioning Cynata as a leader in safer kidney transplantation therapies.

Cynata Therapeutics Updates Director’s Securities Holdings
Nov 30, 2025

Cynata Therapeutics Limited announced a change in the director’s interest, specifically regarding Dr. Paul K Wotton’s securities. The change involves the expiry of 300,000 unlisted options exercisable at $0.97, resulting in Dr. Wotton now holding 220,000 unlisted options and 585,076 ordinary shares. This update reflects the company’s ongoing management of its securities and may influence stakeholder perceptions regarding director engagement and investment strategies.

Cynata Therapeutics Announces Change in Director’s Interest
Nov 30, 2025

Cynata Therapeutics Limited announced a change in the director’s interest, specifically regarding Dr. Darryl Maher’s holdings. On November 29, 2025, 300,000 unlisted options exercisable at $0.97 expired, leaving Dr. Maher with 116,666 ordinary shares and 220,000 unlisted options exercisable at $0.185. This change reflects the expiration of certain options, which may impact the director’s future financial interests in the company.

Cynata Therapeutics Announces Change in Director’s Securities Interests
Nov 30, 2025

Cynata Therapeutics Limited announced a change in the interests of its director, Dr. Geoffrey Brooke, with the expiration of 2,000,000 unlisted options exercisable at $0.97 on November 29, 2025. This change reflects a reduction in Dr. Brooke’s holdings, which may impact the company’s stock dynamics and investor perceptions, although the overall strategic direction of the company remains unaffected.

Cynata Completes Final Patient Visit in Phase 3 Osteoarthritis Trial
Nov 24, 2025

Cynata Therapeutics Limited announced the completion of the final patient visit in its Phase 3 SCUlpTOR trial for CYP-004, targeting osteoarthritis of the knee. This milestone marks the end of a two-year follow-up period, with data analysis expected to conclude by Q2 2026. The trial, conducted in partnership with the University of Sydney, aims to assess whether CYP-004 can modify the disease and alleviate symptoms. Osteoarthritis represents a significant market opportunity, affecting 600 million people globally, and Cynata’s product could offer a less invasive alternative to current treatments.

Cynata Therapeutics Unveils Updated Investor Presentation
Nov 16, 2025

Cynata Therapeutics Limited has released an updated investor presentation, highlighting its ongoing clinical trials and advancements in cell therapy. The company’s Cymerus™ platform continues to demonstrate potential in treating various diseases, positioning Cynata as a significant player in the regenerative medicine industry. The release of this presentation aims to keep shareholders and interested parties informed about the company’s progress and strategic direction.

Cynata Therapeutics Passes Key Resolutions at Annual General Meeting
Nov 13, 2025

Cynata Therapeutics Limited held its Annual General Meeting where all resolutions, including a special resolution for a 10% Placement Facility, were passed. This outcome supports the company’s strategic initiatives and may enhance its financial flexibility, potentially impacting its market positioning and stakeholder interests positively.

Cynata Therapeutics Hosts Investor Webinar to Update on Key Projects
Nov 6, 2025

Cynata Therapeutics Limited announced an investor webinar hosted by CEO Dr. Kilian Kelly, aimed at providing updates on the company’s activities and key projects. The webinar reflects Cynata’s commitment to engaging with shareholders and stakeholders, offering insights into its ongoing clinical trials and the potential impact of its Cymerus™ technology on the regenerative medicine industry.

Cynata Therapeutics Secures $1.7 Million R&D Tax Refund to Boost Cell Therapy Development
Nov 5, 2025

Cynata Therapeutics Limited announced it received a $1.7 million R&D Tax Incentive Refund for the 2024/2025 financial year. This refund will support the advancement of Cynata’s cell therapy product pipeline, enhancing its research and development efforts. The Australian Government’s R&D Tax Incentive program encourages companies to engage in innovative activities, such as the development of Cynata’s Cymerus™ MSC products, by providing tax offsets. This financial boost is expected to positively impact Cynata’s operations and industry positioning by enabling further investment in its advanced therapeutic offerings.

Cynata Therapeutics Approaches Key Clinical Milestones with Promising Trials
Oct 31, 2025

Cynata Therapeutics Limited is poised for a significant period with upcoming results from two major clinical trials expected within the financial year. The Phase 2 trial for acute Graft versus Host Disease and the Phase 3 trial for Osteoarthritis are nearing completion, with results anticipated in Q2 CY 2026. These trials are crucial for demonstrating the clinical potential and scalability of Cynata’s Cymerus™ platform. The company is also advancing its Phase 1/2 kidney transplant trial and has secured a financial runway through mid-CY 2026. Cynata’s strategic positioning is strengthened by regulatory trends favoring advanced therapies, potentially accelerating approval processes.

Cynata Therapeutics Announces Cessation of Securities
Oct 12, 2025

Cynata Therapeutics Limited announced the cessation of 1,000,000 securities, specifically options that expired on October 11, 2025, without being exercised or converted. This cessation reflects routine financial adjustments and may impact the company’s capital structure, but it does not indicate any immediate strategic shifts or operational changes.

Cynata Therapeutics Announces 2025 AGM Details
Oct 10, 2025

Cynata Therapeutics Limited has announced its 2025 Annual General Meeting (AGM) will be held in person on November 13, 2025, at the Australian Institute of Company Directors in Melbourne. Shareholders are encouraged to access the Notice of Meeting and related materials online, as hard copies will not be distributed unless previously requested. The announcement outlines the procedures for proxy voting and provides contact information for shareholder inquiries, emphasizing the company’s commitment to facilitating shareholder engagement and transparency.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Jan 07, 2026