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Noxopharm Ltd. (AU:NOX)
ASX:NOX
Australian Market

Noxopharm Ltd. (NOX) AI Stock Analysis

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AU:NOX

Noxopharm Ltd.

(Sydney:NOX)

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Neutral 46 (OpenAI - 5.2)
Rating:46Neutral
Price Target:
AU$0.10
▲(6.67% Upside)
The score is held back primarily by weak financial performance (large ongoing losses, continued cash burn, and a weaker 2025 balance sheet with higher leverage). Technical indicators are neutral and provide only modest support, while valuation metrics are constrained by negative earnings and no dividend yield data.
Positive Factors
Clinical Trial Progress
Advancing clinical trials for SOF-SKN™ demonstrates progress in drug development, potentially enhancing market position in autoimmune therapeutics.
Patent Acquisition
Securing a US patent for Sofra™ technology strengthens intellectual property, providing a competitive edge in the growing immuno-oncology market.
Strategic Collaborations
Collaborations with academic institutions and government support enhance R&D capabilities, potentially accelerating innovation and market reach.
Negative Factors
Financial Health
Increased leverage and reduced equity indicate financial strain, limiting flexibility and increasing risk, which could hinder long-term growth.
Cash Flow Challenges
Persistent negative cash flow suggests reliance on external funding, posing sustainability risks and potentially impacting operational stability.
Profitability Issues
Ongoing significant losses and negative margins highlight challenges in achieving profitability, which could affect long-term viability.

Noxopharm Ltd. (NOX) vs. iShares MSCI Australia ETF (EWA)

Noxopharm Ltd. Business Overview & Revenue Model

Company DescriptionNoxopharm Limited, a drug development company, focuses on developing treatment options for a range of solid tumor cancers and septic shock in Australia and internationally. It primarily develops Veyonda, which is an adjuvant therapy in chemotherapy and radiotherapy for the treatment of late-stage cancers. The company also develops DARRT program that is in Phase 1b/2a for the treatment of metastatic castration-resistant prostate cancer and other solid tumors; LuPIN with combined therapy of Veyonda and 177Lu-PSMA-617 for the treatment of late-stage prostate cancer; IONIC program with Veyonda, which is combined with the Bristol Myers Squibb checkpoint inhibitor Opdivo for the treatment of various solid tumor types; and chemotherapy enhancement program (CEP) combined with carboplatin for patients with refractory solid tumors in the breast, head and neck, lung, prostate, and ovaries. In addition, it develops NOXCOVID Program, a dose escalation and dose expansion study of NOX66 for the treatment of COVID-19 infection. Further, the company develops programs to treat pancreatic cancer and glioblastoma. Noxopharm Limited has a collaboration with Hudson Institute of Medical Research and The Australian National University for the research and development of therapeutic drug against inflammatory disorders. The company was incorporated in 2015 and is based in Chatswood, Australia.
How the Company Makes MoneyNoxopharm Ltd. generates revenue primarily through the development and commercialization of its drug candidates, particularly those targeting cancer treatment. The company earns money by advancing its proprietary drug technology through clinical trials and obtaining regulatory approvals, which can lead to partnerships with larger pharmaceutical companies or direct commercialization. Additionally, Noxopharm may engage in licensing agreements, where it licenses its technology to other companies in exchange for upfront payments, milestone payments, and royalties on future sales. Strategic partnerships and collaborations with research institutions and other biotech companies can also provide funding and support for their drug development programs, contributing to their revenue streams.

Noxopharm Ltd. Financial Statement Overview

Summary
Noxopharm Ltd. is facing substantial financial challenges, characterized by declining revenues, negative profitability, and poor cash flow performance. Despite having no debt and a strong equity ratio, the company struggles to generate shareholder value and maintain operational efficiency. The firm needs to focus on improving its revenue trajectory and cost management to enhance its financial health.
Income Statement
Noxopharm Ltd. has experienced a significant decline in revenue over the past year, with a revenue decrease of approximately 60% from 2023 to 2024. The company also reports negative gross profit and net income, indicating struggles in profitability. The negative EBIT and EBITDA margins highlight considerable operational inefficiencies, suggesting that the firm is facing challenges in managing its cost structure.
Balance Sheet
The balance sheet displays a positive equity position, with no debt, which suggests a conservative capital structure. However, the return on equity is negative due to consistent net losses, reflecting poor shareholder value generation. The equity ratio remains strong, indicating that the company is primarily financed through equity.
Cash Flow
Noxopharm Ltd. is facing negative free cash flow, although there is an improvement in cash outflows compared to the previous year, indicating some progress in managing cash. The operating cash flow to net income ratio reflects challenges in converting profits into cash, while the absence of capital expenditures suggests limited investment in growth.
BreakdownTTMDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue2.82M2.82M2.40M6.01M5.43M5.61M
Gross Profit-1.45M-1.45M-534.81K5.86M5.17M5.35M
EBITDA-5.38M-5.38M-5.95M-20.85M-23.70M-5.85M
Net Income-4.88M-4.88M-3.58M-15.06M-18.67M-9.35M
Balance Sheet
Total Assets4.58M4.58M6.78M10.13M26.59M47.85M
Cash, Cash Equivalents and Short-Term Investments1.55M1.55M2.32M3.01M14.01M26.80M
Total Debt2.48M2.48M0.000.00160.62K349.31K
Total Liabilities3.89M3.89M1.29M1.06M2.48M7.08M
Stockholders Equity689.96K689.96K5.50M9.07M24.12M40.78M
Cash Flow
Free Cash Flow-5.82M-5.82M-684.31K-10.95M-13.73M-8.85M
Operating Cash Flow-5.82M-5.82M-684.31K-10.95M-13.73M-8.85M
Investing Cash Flow2.48M2.48M0.00123.51K0.00225.23K
Financing Cash Flow2.60M2.60M0.00-178.09K975.73K28.32M

Noxopharm Ltd. Technical Analysis

Technical Analysis Sentiment
Negative
Last Price0.09
Price Trends
50DMA
0.09
Negative
100DMA
0.10
Negative
200DMA
0.09
Positive
Market Momentum
MACD
<0.01
Positive
RSI
45.94
Neutral
STOCH
80.56
Negative
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For AU:NOX, the sentiment is Negative. The current price of 0.09 is below the 20-day moving average (MA) of 0.10, below the 50-day MA of 0.09, and above the 200-day MA of 0.09, indicating a neutral trend. The MACD of <0.01 indicates Positive momentum. The RSI at 45.94 is Neutral, neither overbought nor oversold. The STOCH value of 80.56 is Negative, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for AU:NOX.

Noxopharm Ltd. Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
61
Neutral
AU$68.10M9.9327.24%2.81%0.65%-9.90%
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
50
Neutral
AU$87.28M-9.12-49.72%10.78%
46
Neutral
AU$27.47M-5.63-157.93%-36.89%
45
Neutral
AU$8.22M-1.69-469.35%46.28%
44
Neutral
AU$193.03M-7.400.66%
44
Neutral
AU$111.71M-13.68-47.98%700.00%26.88%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
AU:NOX
Noxopharm Ltd.
0.09
0.00
0.00%
AU:PTX
Prescient Therapeutics Limited
0.08
0.03
60.00%
AU:CHM
Chimeric Therapeutics Ltd.
AU:EZZ
EZZ Life Science Holdings Ltd.
1.45
-1.43
-49.65%
AU:RCE
Recce Pharmaceuticals Ltd.
0.67
0.20
42.55%
AU:ALA
Arovella Therapeutics Limited
0.09
-0.08
-47.06%

Noxopharm Ltd. Corporate Events

Noxopharm Ltd. Announces Director’s Interest Change
Dec 12, 2025

Noxopharm Ltd. has announced a change in the director’s interest, specifically involving Fred Bart, who has acquired 250,000 options and 1,250,000 convertible notes through 4F Investment Pty Limited. This change was approved by shareholders on November 18, 2025, and reflects a strategic move to enhance the company’s financial instruments, potentially impacting its market positioning and shareholder value.

Noxopharm Issues Convertible Notes to Restructure Capital
Dec 12, 2025

Noxopharm Limited has issued 1,250,000 convertible notes and 250,000 unlisted options to 4F Investments Pty Limited, associated with a company director. This financial maneuver, involving a conversion of an unsecured loan into convertible notes, will not bring new cash inflow but will impact the company’s capital structure by potentially increasing the number of shares if the notes are converted. The move is designed to allow the resale of shares without disclosure to retail investors, potentially diluting existing shareholdings and altering the company’s equity distribution.

Noxopharm Ltd. Issues New Equity Securities to Bolster Growth
Dec 11, 2025

Noxopharm Ltd. has announced the issuance of unquoted equity securities, including 250,000 options expiring in 2027 and 1,250,000 convertible notes. This move is part of the company’s financial strategy to support its ongoing operations and growth in the oncology sector, potentially impacting its market position and stakeholder interests.

Noxopharm Advances SOF-SKN™ Clinical Trial for Autoimmune Diseases
Dec 2, 2025

Noxopharm Limited announced the successful completion of the first multiple-dose cohort in the HERACLES clinical trial for SOF-SKN™, a novel drug candidate for autoimmune diseases like cutaneous lupus erythematosus. The trial, which is being conducted in Australia, aims to assess the safety and tolerability of SOF-SKN™ through repeated applications, reflecting real-world usage. The trial’s progression to the second and final cohort underscores the drug’s potential impact on the autoimmune disease therapeutics market, which is projected to grow significantly.

Noxopharm’s AGM Resolutions Passed, Highlighting Growth Potential of Sofra Platform
Nov 18, 2025

Noxopharm Limited announced that all resolutions were passed at its Annual General Meeting, with significant support for the adoption of the Remuneration Report. The company’s Sofra technology platform, which targets inflammatory and autoimmune diseases, holds potential for significant market impact, given the projected growth in the autoimmune disease therapeutics and immuno-oncology markets.

Noxopharm Unveils 2025 AGM Presentation, Showcasing Clinical and Market Advancements
Nov 17, 2025

Noxopharm Limited has released its 2025 AGM Corporate Presentation, highlighting significant progress in its HERACLES clinical trial and the growing market opportunities for its Sofra™ technology in treating inflammation and cancer. The company has achieved a milestone with its first US patent grant and is gaining increased recognition and interest from third parties in its Sofra assets, positioning it well in the multi-billion dollar biotech market.

Noxopharm Advances Sofra™ Platform with Promising Clinical Trials
Nov 17, 2025

Noxopharm Limited’s 2025 AGM highlighted significant progress in advancing its Sofra™ technology platform, particularly with the SOF-SKN™ clinical trial in Australia. This advancement enhances the company’s reputation and attracts external stakeholder interest, evidenced by a US patent grant and support from the Victorian government. The company is well-positioned to capitalize on the growing interest in RNA technology and the rise in autoimmune diseases, while maintaining prudent operational spending and exploring funding opportunities.

Noxopharm Advances HERACLES Trial with SOF-SKN Dosing
Nov 16, 2025

Noxopharm Limited has commenced the second part of its HERACLES clinical trial, administering the first dose of SOF-SKN™, a novel drug candidate for autoimmune diseases like cutaneous lupus erythematosus. This phase aims to evaluate the safety and tolerability of SOF-SKN through repeated dosing, reflecting real-world conditions. The trial’s success could enhance Noxopharm’s position in the regulatory approval process and potentially expand the use of SOF-SKN to other autoimmune-related skin diseases, positioning the company to capture a share of the growing global cutaneous lupus market, valued at over US$3.3 billion.

Noxopharm and UNSW Sydney Collaborate on Inflammation Study with Government Grant
Nov 10, 2025

Noxopharm Limited has announced a collaboration with UNSW Sydney, supported by a TechVoucher grant from the NSW Government, to conduct an early-stage feasibility study on their Sofra™ technology. This study aims to explore the potential of Noxopharm’s anti-inflammatory oligonucleotides to reduce inflammation caused by implants. The initiative highlights the versatility of the Sofra™ platform, which targets a wide range of inflammatory and autoimmune diseases, and underscores Noxopharm’s strategic partnerships to enhance its market positioning in the biotech industry.

Noxopharm Advances HERACLES Trial for Autoimmune Drug SOF-SKN
Nov 4, 2025

Noxopharm Limited has commenced the second phase of its HERACLES clinical trial for SOF-SKN, a new drug candidate aimed at treating autoimmune diseases like cutaneous lupus erythematosus (CLE). The trial, which will test multiple ascending doses, aims to ensure the drug’s safety over repeated applications, potentially accelerating its development timeline by skipping the lowest dose cohorts. This advancement could position Noxopharm favorably within the growing global CLE market, valued at over US$3.3 billion, and further applications of the Sofra technology could extend to other autoimmune and inflammatory diseases.

Noxopharm Advances Sofra Platform with New Collaborations and Promising Trial Results
Oct 30, 2025

Noxopharm Limited has reported significant progress in its September 2025 Quarterly Activities Report, highlighting new collaborations and promising trial results. The company has signed several collaboration agreements with institutions interested in its Sofra technology platform, which is being explored for various inflammatory diseases. A US company, Tezcat Biosciences, has shown promising preclinical results using Noxopharm’s oligonucleotides in a novel drug candidate. Additionally, Noxopharm’s HERACLES clinical trial has demonstrated that its SOF-SKN treatment is safe and well-tolerated, supporting the platform’s potential in treating autoimmune diseases. The extension of convertible notes and access to government rebates further strengthen the company’s financial position.

Noxopharm Secures First US Patent for Sofra™ Technology in Cancer Treatment
Oct 21, 2025

Noxopharm Limited has secured its first US patent for the Sofra™ technology platform, which is designed to harness immune-modulatory oligonucleotides for cancer treatment. This patent protects the structure of Noxopharm’s assets, ensuring the commercial value of their ongoing cancer research. The Sofra platform, developed in collaboration with the Hudson Institute of Medical Research, shows potential for versatile applications in mitigating inflammation and weaponizing the immune system against cancer. This milestone positions Noxopharm favorably in the growing immuno-oncology market, projected to expand significantly in the coming years.

Noxopharm Limited Announces 2025 AGM Details and Key Resolutions
Oct 13, 2025

Noxopharm Limited has announced its 2025 Annual General Meeting (AGM) will be held as a physical meeting on November 18, 2025, in Sydney. The AGM will address several key resolutions, including the adoption of the remuneration report, re-election of a director, and approval of future securities issues and incentive plans. This meeting is crucial for stakeholders as it outlines the company’s strategic plans and governance decisions, impacting its market positioning and operational focus.

Noxopharm Advances Clinical Trials, Boosts Stakeholder Interest
Oct 13, 2025

Noxopharm Limited has released its Annual Report for the year ending June 30, 2025, highlighting significant progress in its clinical trials and growing interest in its Sofra™ technology platform. The company has successfully advanced its first asset, SOF-SKN™, from preclinical studies to clinical trials, demonstrating its ability to quickly translate research into real-world applications. This milestone has attracted considerable external stakeholder interest, enhancing Noxopharm’s industry positioning and potential impact on cancer and inflammation treatment.

Noxopharm Releases FY2025 Governance Documents
Oct 13, 2025

Noxopharm Limited has released its Appendix 4G and Corporate Governance Statement for FY2025, highlighting its commitment to transparency and adherence to ASX governance standards. This announcement underscores the company’s dedication to maintaining robust corporate governance practices, which is crucial for its stakeholders and enhances its positioning within the biotech industry.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Dec 30, 2025