Community Adoption And AccessThe simplicity of the AlloNK plus anti-CD20 antibody regimen and its benign safety profile enabled outpatient administration in community rheumatology sites, which could broaden patient access and facilitate faster commercial uptake compared with therapies requiring specialized centers.
Mechanism-driven EfficacyConsistent and complete B-cell depletion followed by reconstitution of naive B cells supports an immune reset mechanism that could translate into durable clinical benefit for autoimmune indications.
Safety ProfileClinical data indicate AlloNK combined with an anti-CD20 antibody produced no cytokine release syndrome, no neurotoxicity, no graft-versus-host disease, and no high-grade AlloNK-related adverse events in treated patients, suggesting a markedly cleaner safety profile than many other cell therapies.