We believe investors had expected fourth-quarter revenue to be below consensus estimates since third-party script data had implied more modest Amvuttra TRx growth and was reflected by the 15% stock decline since December 2025. Therefore, we expect Alnylam shares to trade higher on the strong 2026 TTR franchise guide and 2030 corporate plan outline. Total TTR 2026 revenue guidance of $4,400 million to $4,700 million (83% growth compared to 2025 at the midpoint) is substantially above our estimate of $3,936 million. We have updated our model and now estimate $4,551 million in TTR franchise revenues and $5,124 million in total net product revenues. We provide variance from fourth quarter 2025 estimates in exhibit 1, summarize announced 2026 guidance in exhibit 2, and detail our model updates in exhibit 3.