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Aethlon Medical Inc (AEMD)
NASDAQ:AEMD
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Aethlon Medical (AEMD) AI Stock Analysis

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AEMD

Aethlon Medical

(NASDAQ:AEMD)

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Underperform 38 (OpenAI - 4o)
Rating:38Underperform
Price Target:
Aethlon Medical's overall stock score is low due to significant financial challenges, including persistent losses and cash flow issues. The technical indicators suggest negative momentum, and the valuation is unattractive given the negative P/E ratio and lack of dividends. While the earnings call presented some positive strategic efforts, such as cost reduction and trial advancements, the hurdles in clinical trials and financial constraints weigh heavily on the stock's outlook.
Positive Factors
Cost Reduction Achievements
Significant cost reductions enhance financial stability by lowering operational expenses, allowing more resources to be allocated towards strategic initiatives like clinical trials.
Protocol Amendment for Oncology Trial
The protocol amendment accelerates patient enrollment and trial progress, potentially leading to faster data collection and improved clinical outcomes.
Milestone in Oncology Trials
Achieving treatment milestones in oncology trials demonstrates progress in clinical efficacy, which is crucial for future regulatory approvals and market expansion.
Negative Factors
Limited Patient Enrollment
Challenges in patient enrollment could delay trial timelines and data collection, impacting the company's ability to demonstrate clinical efficacy and secure regulatory approvals.
Potential Increase in Operating Expenses
Rising operating expenses may strain financial resources, potentially limiting the company's ability to invest in other strategic areas and impacting long-term financial health.
Financial Challenges
Ongoing financial challenges, including negative cash flow and lack of revenue growth, threaten the company's sustainability and ability to fund future operations and development.

Aethlon Medical (AEMD) vs. SPDR S&P 500 ETF (SPY)

Aethlon Medical Business Overview & Revenue Model

Company DescriptionAethlon Medical, Inc., a medical technology company, focuses on developing products to diagnose and treat life and organ threatening diseases in the United States. The company develops Aethlon Hemopurifier, a clinical-stage immunotherapeutic device that removes tumor-derived exosomes and life-threatening viruses from the human circulatory system, including removal of COVID-19 virus, associated variants, and related exosomes. Aethlon Medical, Inc. has a collaboration with the University of Pittsburgh Medical Center Hillman Cancer Center for studies related to head and neck cancer. The company was founded in 1999 and is based in San Diego, California.
How the Company Makes MoneyAethlon Medical makes money through the development and commercialization of its Hemopurifier product, targeting both therapeutic and diagnostic markets. Revenue is primarily generated from grants, research and development contracts, and potential sales or licensing of its proprietary technology. As a company focused on early-stage biotechnology, Aethlon also relies on government funding and partnerships with research institutions to support its development efforts. Key factors contributing to its earnings include the expansion of its product applications, regulatory approvals, and strategic collaborations that enhance its market reach and product development pipeline.

Aethlon Medical Earnings Call Summary

Earnings Call Date:Nov 12, 2025
(Q2-2026)
|
% Change Since: |
Next Earnings Date:Feb 16, 2026
Earnings Call Sentiment Neutral
The earnings call highlighted significant progress in clinical trials and substantial reduction in operating expenses, indicating effective cost management. Nonetheless, challenges in patient recruitment for the oncology trial and concerns about cash reserves present potential hurdles. The company's strategic focus on its core projects while managing resources optimally reflects a balanced approach.
Q2-2026 Updates
Positive Updates
Australian Oncology Trial Progress
The ongoing progress in the Australian oncology trial of the Hemopurifier shows promising results. All three participants in Cohort 1 completed a single 4-hour Hemopurifier treatment without any device deficiencies or immediate complications. The trial is advancing to the second cohort with plans for participants to receive two Hemopurifier treatments during a 1-week treatment period.
Financial Expense Reduction
Operating expenses for the quarter ending September 30, 2025, were approximately $1.5 million, down by approximately 48% from $2.9 million in the same period of 2024. This reduction was reflected across payroll, general and administrative expenses, and professional fees.
Preclinical R&D Developments
Aethlon Medical presented preclinical data on Long COVID at the Keystone Symposium, demonstrating the binding of extracellular vesicles from Long COVID patients to the Hemopurifier. The company is preparing a manuscript with UCSF Medical Center collaborators for publication.
Negative Updates
Slow Enrollment in Oncology Trial
Enrollment for Cohort 2 in the Australian oncology trial has been slower than anticipated, attributed to the novel nature of extracorporeal therapies for cancer patients and the complexity of the trial procedures.
Cash Balance Concerns
As of September 30, 2025, Aethlon Medical had a cash balance of approximately $5.8 million, which might raise concerns about the company's ability to sustain operations without additional funding or revenue streams.
Company Guidance
During the Aethlon Medical Second Quarter Fiscal 2026 Earnings Call, the company provided several key updates and metrics regarding its ongoing projects and financial status. Dr. Steven LaRosa shared progress on the Australian oncology trial, highlighting that all three participants in Cohort 1 completed a 4-hour Hemopurifier treatment without adverse events, and the trial is advancing to Cohort 2. The primary endpoint of the trial is safety, with secondary focus on extracellular vesicle (EV) concentration changes. Financially, Aethlon reported a cash balance of approximately $5.8 million as of September 30, 2025, with consolidated operating expenses decreasing by 48% to $1.5 million, down from $2.9 million in the same period of 2024. This reduction was attributed to lower payroll, administrative expenses, and professional fees, resulting in an operating loss decrease to $1.5 million from $2.8 million in the prior year. The company is actively seeking to optimize its resources and accelerate trial enrollment through strategic initiatives.

Aethlon Medical Financial Statement Overview

Summary
Aethlon Medical faces significant financial challenges, with no revenue growth and persistent losses. The balance sheet suggests limited financial flexibility despite low leverage. Cash flow issues exacerbate these concerns, with substantial cash outflows overshadowing financing efforts. The company needs to address its revenue generation and operational efficiency to improve its financial standing.
Income Statement
10
Very Negative
Aethlon Medical's income statement reveals significant challenges, with consistent negative gross profit and net income across both TTM and annual reports. The absence of revenue in the latest TTM indicates a severe downturn. Persistent negative EBIT and EBITDA margins highlight ongoing operational inefficiencies, with no visible improvement in revenue growth.
Balance Sheet
30
Negative
The balance sheet shows a moderate equity position with a relatively stable debt level. The Debt-to-Equity ratio remains low, indicating conservative leverage. However, the equity ratio suggests reliance on stockholder equity for asset financing, which could limit future growth potential. Despite a sizable cash position, the company's assets are declining, hinting at potential liquidity concerns.
Cash Flow
20
Very Negative
Cash flow analysis indicates severe cash management issues, with negative free cash flow and operating cash flow across periods. The large discrepancy between operating cash flow and net income raises concerns about the sustainability of operations. Despite positive financing cash flow, likely from equity issuance, the free cash flow remains negative, reflecting ongoing cash burn.
BreakdownTTMDec 2025Dec 2024Dec 2023Dec 2022Dec 2021
Income Statement
Total Revenue0.000.000.00574.25K294.17K659.10K
Gross Profit-391.72K0.000.00574.25K294.17K659.10K
EBITDA-10.83M-13.04M-12.28M-11.66M-10.30M-7.85M
Net Income-11.26M-13.39M-12.21M-12.03M-10.42M-7.89M
Balance Sheet
Total Assets7.32B7.36M8.25M17.51M19.42M10.67M
Cash, Cash Equivalents and Short-Term Investments5.85B5.50M5.44M14.53M17.07M9.86M
Total Debt496.77M649.75K940.32K1.21M729.41K42.54K
Total Liabilities1.58B2.24M2.48M2.44M2.43M1.38M
Stockholders Equity5.75B5.12M5.77M15.06M17.13M9.43M
Cash Flow
Free Cash Flow-1.72B-7.65M-10.38M-11.45M-10.12M-6.82M
Operating Cash Flow-1.72B-7.65M-10.13M-10.51M-9.77M-6.76M
Investing Cash Flow0.000.00-250.87K-943.11K-349.19K-59.88K
Financing Cash Flow736.11K7.73M1.29M8.91M17.37M7.13M

Aethlon Medical Technical Analysis

Technical Analysis Sentiment
Negative
Last Price4.21
Price Trends
50DMA
5.68
Negative
100DMA
8.81
Negative
200DMA
19.01
Negative
Market Momentum
MACD
-0.46
Negative
RSI
42.80
Neutral
STOCH
63.40
Neutral
Evaluating momentum and price trends is crucial in stock analysis to make informed investment decisions. For AEMD, the sentiment is Negative. The current price of 4.21 is below the 20-day moving average (MA) of 4.27, below the 50-day MA of 5.68, and below the 200-day MA of 19.01, indicating a bearish trend. The MACD of -0.46 indicates Negative momentum. The RSI at 42.80 is Neutral, neither overbought nor oversold. The STOCH value of 63.40 is Neutral, not indicating any strong overbought or oversold conditions. Overall, these indicators collectively point to a Negative sentiment for AEMD.

Aethlon Medical Risk Analysis

Aethlon Medical disclosed 61 risk factors in its most recent earnings report. Aethlon Medical reported the most risks in the "Finance & Corporate" category.
Finance & Corporate - Financial and accounting risks. Risks related to the execution of corporate activity and strategy
Latest Risks Added 0 New Risks

Aethlon Medical Peers Comparison

Overall Rating
UnderperformOutperform
Sector (51)
Financial Indicators
Name
Overall Rating
Market Cap
P/E Ratio
ROE
Dividend Yield
Revenue Growth
EPS Growth
51
Neutral
$7.86B-0.30-43.30%2.27%22.53%-2.21%
43
Neutral
$3.92M-0.20-178.18%-49.63%82.22%
41
Neutral
$3.38M-0.03-173.74%82.96%82.04%
40
Underperform
$5.63M-0.14-352.39%63.87%
38
Underperform
$3.44M-0.07-191.39%76.53%
29
Underperform
$2.27M-0.04-126.20%97.70%
* Healthcare Sector Average
Performance Comparison
Ticker
Company Name
Price
Change
% Change
AEMD
Aethlon Medical
4.21
-26.38
-86.24%
VTAK
Catheter Precision
2.05
-5.11
-71.37%
BJDX
Bluejay Diagnostics
1.25
-2.64
-67.87%
TIVC
Tivic Health Systems
1.83
-2.67
-59.33%
AMIX
Autonomix Medical, Inc.
0.93
-2.94
-75.97%

Aethlon Medical Corporate Events

Business Operations and StrategyFinancial Disclosures
Aethlon Medical Achieves Milestone in Oncology Trials
Positive
Feb 12, 2025

In its recent financial release, Aethlon Medical reported a significant milestone in its oncology trials in Australia, announcing the first patient treated with the Hemopurifier for solid tumors not responding to anti-PD-1 antibodies on January 29, 2025. The company has also implemented strategic cost-cutting measures, reducing operating expenses by 50% from the previous year, and made protocol amendments to accelerate trial timelines and improve patient enrollment. These developments are crucial for enhancing the company’s clinical program efficiency and potentially improving therapeutic responses in future oncology efficacy trials.

Glossary
BuyA stock rated as a "Buy" is expected to perform better than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock is likely to deliver higher returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
HoldA stock rated as a "Hold" is expected to perform in line with the overall market or a specific benchmark. This rating indicates that the stock is neither particularly compelling nor unfavorable for investment. Note: This is not investment advice; please consult a financial advisor before making investment decisions.
SellA stock rated as a "Sell" is expected to perform worse than the overall market or a specific benchmark over the near-to-medium term. This rating suggests the stock may deliver lower returns compared to other stocks in the same sector or market index. Note: This is not investment advice; please consult a financial advisor before making investment decisions.

Disclaimer

This AI Analyst Stock Report is automatically generated by our AI systems using advanced algorithms and publicly available financial, technical, and market data. While the information provided aims to be accurate and insightful, it is intended for informational purposes only and should not be considered financial advice. Any content created by an AI (Artificial Intelligence) system may contain inaccuracies and/or contain errors. Investing in stocks carries inherent risks, and past performance is not indicative of future results. This report does not account for your personal financial circumstances, objectives, or risk tolerance. Always conduct your own research or consult with a qualified financial advisor before making investment decisions. The analysis and recommendations provided are based on historical and current data and may not fully reflect future market conditions or unexpected developments. Neither the creators of this report nor its affiliated entities guarantee the accuracy, completeness, or reliability of the information presented. Use this report at your own discretion and risk.Date of analysis: Apr 22, 2025