Australian oncology trial advancing with favorable safety signals
Cohort 1 completed (3 participants received a single Hemopurifier treatment) with no device-related serious adverse events or dose-limiting toxicities; directional improvements observed in extracellular vesicle (EV) counts and immune cell numbers. Cohort 2: two participants have completed 2 HP treatments and a third patient is enrolled and expected to be treated by end of February; independent DSMB review targeted for late March to recommend advancement to Cohort 3 or additional patients.
Expanded EV research and potential multi-indication pipeline
Ongoing expansion of extracellular vesicle (EV) research supporting Hemopurifier as a potential multi-indication therapeutic. Published trial design in BMJ Open; Long COVID preclinical data show GNA affinity resin binds EVs and decreases microRNAs linked to immune dysregulation (preprint on bioRxiv); prior data show platelet-derived EV removal (bioRxiv). Company exploring additional EV cargo (e.g., viral particles) and plans disease-plasma studies to broaden indications.
Workstream toward simplified delivery (SLAMB) could expand clinical settings
Under a Material Transfer Agreement with Stavro to study compatibility with SLAMB system (single small-lumen catheter and simplified pump). If compatible, could shift Hemopurifier treatments from dialysis units with large double-lumen catheters and dialysis machines to oncology units or infusion centers using PICC-like catheters, reducing invasiveness and operational complexity.
Meaningful year-to-date operating expense reduction
Consolidated operating expenses for the nine months ended December 31, 2025 decreased to $5.36 million from $7.34 million year-ago, a reduction of $1.98 million or 27%, driven by lower payroll, general & administrative costs and professional fees—reflecting disciplined cost management.
Enrollment momentum via Trialfacts and Dedicated
Contracting marketing and prescreening partners (Trialfacts for online advertising; Dedicated for phone prescreening) has produced an uptick in interested potential participants and a referral pool for investigative sites, providing a queue of candidates that could accelerate enrollment into Cohort 3 once approved by the DSMB.