Strong Full-Year and Quarterly Revenue Growth
Total company revenue reported $277.0M for FY2025 (55% YoY growth); Q4 revenue $71.7M (51% YoY). On a basis excluding noncash Genentech amortization, FY revenue was $235.7M (42% YoY).
MRD (clonoSEQ) Outperformance
Full-year MRD revenue grew 46% YoY to $212M (including $19.5M in milestones). ClonoSEQ clinical testing revenue grew 64% for FY2025 and 59% in Q4 YoY; Q4 volumes reached a record 30,038 tests, up 43% YoY and 11% sequentially.
ASP Expansion and Payer Wins
U.S. average selling price (ASP) rose to $1,307 per test for the year (up 17% YoY) and exited Q4 at ~$1,350. Company renegotiated 8 major payer contracts and signed new agreements (Anthem, Centene, Humana, Aetna, Horizon, multiple Blues, Florida, LA Care), supporting a target ASP of ~$1,400 in 2026.
Material Margin Improvement
Sequencing gross margin (ex-milestones/licensing/Genentech) improved to 71% in Q4 (up 12 percentage points YoY) and 66% for the full year (up from 53% in 2024), helped by production efficiencies and NovaSeq X+ transition.
Profitability Progress and Cash Position
Total company adjusted EBITDA improved to $12.2M for FY2025 from a loss of $80.4M in 2024; Q4 adjusted EBITDA was $4.1M vs. a loss of $16.4M a year ago. MRD adjusted EBITDA was positive $15.2M in 2025. Year-end cash, cash equivalents and marketable securities were $227M.
Commercial & Operational Execution
Broad-based volume drivers: blood-based testing reached 47% of clonoSEQ tests in Q4 (up from 41% YoY); community testing represented ~33% of tests in Q4 (up sequentially). Epic integrations completed in 8 accounts during Q4 (total 173 integrated accounts now driving ~40% of ordering volume). Commercial payer cash collections improved by 74% YoY.
Immune Medicine Data and Partnerships
Immune Medicine scaled to >5 million paired TCRs covering ~20,000 antigens and ~50 HLA types. Immune Medicine revenue grew (Q4 $9.8M vs $3.8M prior year; FY $23.4M, +17% YoY) and the company announced two distinct Pfizer data licensing/target-discovery partnerships.
Clear 2026 Guidance and Path to Cash Flow
2026 guidance: MRD revenue $255M–$265M (midpoint implies 22% YoY growth, 30% excluding milestones), clonoSEQ volume expected to grow >30% YoY, blood-based testing to exceed 50% of MRD volume, community >35% share, ASP target ~ $1,400. Company expects positive adjusted EBITDA and positive free cash flow by end of 2026.