Net Product Revenue Growth
Q1 2026 net product revenues of $20.0M versus $17.4M in Q1 2025, an increase of approximately 15%, driven primarily by quarter-to-quarter customer ordering variability with underlying demand described as broadly stable.
Reduced Operating Expenses (Non-GAAP)
Total adjusted (non-GAAP) operating expenses were $42.9M for Q1 2026, down 13% versus Q1 2025, primarily due to lower R&D spending and active cost management.
Improved Net Loss
GAAP net loss improved to $33.0M ($0.21 per share) in Q1 2026 from $38.6M ($0.36 per share) in Q1 2025 (approximate 14.5% reduction). Non-GAAP adjusted net loss improved to $19.7M from $24.0M (approximate 17.9% reduction).
Cash Balance and Runway
Cash and cash equivalents of $231.0M at March 31, 2026 (down from $261.3M at 12/31/2025), with management stating an expected cash runway at least into 2028.
Upcoming Clinical and Regulatory Catalysts
Multiple near‑term catalysts: expected LOTIS-5 top-line readout before end of June 2026 (Phase III confirmatory trial of ZYNLONTA + rituximab); LOTIS-7 enrollment expected complete in Q2 with full data by year-end 2026; indolent lymphoma IIT data anticipated between end-2026 and mid-2027. Management plans sBLA submission by year-end 2026 if LOTIS-5 is positive.
Commercial Positioning and Long-Term Potential
Management reiterates ZYNLONTA's established role as a single-agent third-line-plus DLBCL therapy and projects potential peak U.S. annual revenues of $600M to $1B assuming compendia listing and regulatory approvals from lifecycle expansion.