Commercial Launch Momentum and Revenue
Q1 2026 net product revenue of $18.7M and nearly $50M in total net product revenue to date; steady quarter-over-quarter growth since the May 2025 launch and management expects an increase from Q1 to Q2. Active prescribers expanded to more than 400 through April with a 60/40 split between GynOncs and MedOncs.
LGSOC Franchise Nearing Self-Sustainability
Company reiterates belief that the LGSOC franchise (AVMAPKI FAKZYNJA CO-PACK) will be self-sustaining in H2 2026, meaning CO-PACK revenues will support both commercial operations and ongoing clinical trials for avutometinib + defactinib.
Patient Access and Affordability Metrics
Approximately 65% of commercially eligible patients use the Verastem Cares Co-Pay Program; average co-pay for commercially insured patients is under $30. Time to fill initial prescriptions remains 12–14 days and payer mix is ~50% commercial / 50% Medicare.
Robust VS-7375 (Target-D) Clinical Program Advancement
VS-7375 Target-D program advanced: Target-D-101 Phase I/II ongoing (dose escalation up to 1,200 mg), and three Phase II registration-directed trials (Target-D 201 PDAC, 202 NSCLC, 203 CRC) initiated for 900 mg go-forward dose with primary endpoint overall response rate (BICR) and DOR as key secondary endpoint. First patients in Phase II anticipated mid-year.
PK and Tolerability Support Higher Go-Forward Dose
Updated PK data show 900 mg delivers serum levels at or above target with clear separation from 600 mg; 600 mg already showing responses. Tolerability in U.S. patients reported substantially better than previously reported China data (no significant liver dysfunction or hematologic issues observed to date).
Operational Leadership and Commercial Optimization
Appointment of experienced Chief Commercial Officer (Dan Lyons) and additional commercial personnel (including two added sales positions) plus launch of the 'Reimagine Recurrent LGSOC' physician/patient campaign and intensified post-scripture patient outreach to improve adherence and earlier use at first recurrence.
Balance Sheet and Runway
Cash, cash equivalents and investments of $181.7M at quarter end; company expects current cash plus future CO-PACK revenues to provide runway into the first half of 2027 (roughly ~12 months), and management is focused on nondilutive financing opportunities.