Fanapt Strong Commercial Growth
Full-year Fanapt net product sales rose 24% to $117.3M (2025 vs 2024); total prescriptions (TRx) increased 28% and new-to-brand prescriptions (NBRx) surged 149% for the year. Q4 Fanapt sales were $33.2M, up 25% YoY and 6% QoQ; Q4 TRx +36% YoY and NBRx +108% YoY.
Company Revenue Growth
Total revenues for FY2025 were $216.1M, a 9% increase vs $198.8M in FY2024; Q4 revenues were $57.2M, up 8% YoY and 2% QoQ.
Regulatory Approval for Nereus (tradipitant)
FDA approved tradipitant (Nereus) on December 30, 2025 for prevention of motion-induced vomiting — described as the first new oral pharmacologic option in the space in over 40 years; commercial availability expected late Q2 / early Q3 2026.
Robust Late-Stage Pipeline and Recent Submissions
Imsidolimab BLA submitted in Q4 2025 for generalized pustular psoriasis with regulatory/patent exclusivity expected into the late 2030s; an NDA under FDA review for bipolar 1 disorder/schizophrenia with PDUFA Feb 21, 2026; multiple Phase III programs ongoing (MDD adjunct, iloperidone LAI for relapse prevention, VQW765 for SAD, PONVORY trials in psoriasis and UC).
Guidance and Growth Outlook
2026 revenue guidance for marketed products of $230M–$260M (midpoint implies ≈13% growth vs 2025); Fanapt guidance $150M–$170M (midpoint implies ≈36% growth vs 2025) with management attributing growth primarily to TRx/volume expansion.
Commercial Capability Expansion
Sales force expanded from ~160 reps at end of 2024 to ~300 reps at end of 2025 (plus ~50 specialty reps); face-to-face calls more than doubled YoY and a direct-to-consumer campaign launched in Q1 2025 to boost brand awareness.
PONVORY Sequential Improvement
PONVORY net product sales stable to slightly down for year ($27.4M, -2% YoY) but Q4 showed improvement to $7.6M (+17% YoY, +8% QoQ) with underlying patient demand modestly increasing sequentially over the last three quarters.