Progress in Neurology Therapies
Sangamo has advanced its prioritized neurology therapies towards the clinic, securing its first-ever neurology IND in idiopathic small fiber neuropathy and demonstrating non-clinical proof of concept for a product candidate in prion disease.
Strategic Partnerships
Sangamo announced two blue-chip pharma agreements for neurotrophic capsids with Genentech and Astellas, expanding their neurology disease targets.
Fabry Disease Gene Therapy Advancements
Sangamo's Fabry gene therapy study continues to generate best-in-class data, with a pivotal data readout expected in mid-2025. The FDA has provided a clear regulatory pathway to accelerated approval.
Financial Achievements
Since 2023, Sangamo has reduced non-GAAP operating expenses by nearly half year-over-year and raised over $100 million in funding through non-dilutive license fees, milestone payments, and equity financing.
ST-503 Development for Chronic Neuropathic Pain
ST-503 is ready to enter the clinic, targeting Nav1.7 sodium channels in sensory neurons, with promising preclinical results showing significant reduction in pain hypersensitivity.