The earnings call for Praxis Precision Medicine was predominantly positive, with significant achievements in clinical trial results, particularly for vormatrigine, which demonstrated best-in-disease efficacy. The company also highlighted strong recruitment capabilities and potential mood benefits from its treatments. However, the high discontinuation rate in the RADIANT study was noted as a challenge.
Company Guidance -
Q3 2025
During the Praxis Precision Medicine's conference call, the company provided impressive guidance on the progress of their drug vormatrigine for treating focal epilepsy. They reported a median seizure reduction of over 56% in the RADIANT study, with 60% of patients achieving at least a 50% reduction in seizures. Notably, 22% of patients were completely seizure-free during the second month of treatment. The company plans to extend their clinical agenda with the POWER1 and POWER2 studies, with enrollment expected to complete in 2026. They also highlighted a cash runway extending into 2028, supporting their robust pipeline. The trial demonstrated a favorable safety profile, with most adverse events being mild to moderate. Praxis is optimistic about vormatrigine's potential as a monotherapy, with plans to initiate the POWER3 study in early 2026.
Best-in-Disease Efficacy for Vormatrigine
Vormatrigine showed best-in-disease efficacy in the RADIANT study, with a median seizure reduction of over 56%. Importantly, 60% of patients achieved at least a 50% reduction in seizures, and over 22% of patients were completely seizure-free during the second month of treatment.
Strong Recruitment and Execution
The RADIANT study exceeded its enrollment target, demonstrating effective recruitment capabilities. Praxis also has a cash runway extending into 2028, supporting its ambitious clinical agenda.
Potential Mood Benefits
Patients reported positive impacts on mood during the RADIANT study, prompting Praxis to include depression and mood endpoints in the POWER2 study design.
Praxis Precision Medicines (PRAX) Earnings, Revenues Date & History
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The table shows recent earnings report dates and whether the forecast was beat or missed. See the change in forecast and EPS from the previous year.
Beat
Missed
PRAX Earnings-Related Price Changes
Report Date
Price 1 Day Before
Price 1 Day After
Percentage Change
Aug 04, 2025
$54.09
$51.09
-5.55%
May 02, 2025
$38.06
$40.24
+5.73%
Feb 28, 2025
$65.03
$38.60
-40.64%
Nov 06, 2024
$72.73
$71.87
-1.18%
Earnings announcements can affect a stock’s price. This table shows the stock's price the day before and the day after recent earnings reports, including the percentage change.
FAQ
When does Praxis Precision Medicines (PRAX) report earnings?
Praxis Precision Medicines (PRAX) is schdueled to report earning on Nov 05, 2025, Before Open (Confirmed).
What is Praxis Precision Medicines (PRAX) earnings time?
Praxis Precision Medicines (PRAX) earnings time is at Nov 05, 2025, Before Open (Confirmed).
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